五环三萜化合物调控中东呼吸综合征冠状病毒与宿主细胞识别的分子机制和结构基础研究

21702007
2017
B0706.药物化学生物学
俞小娟
青年科学基金项目
北京大学
26万元
晶体结构;作用机制;药物靶点;中东呼吸综合征冠状病毒;五环三萜
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 靶向流感病毒进入(细胞)抑制剂研究进展 期刊论文 李曼;李海伟;梁烁斌;田振宇;周德敏;肖苏龙
2 Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor. 期刊论文 Chen Yingying;Wang Xinchen;Zhu Yinbiao;Si Longlong;Zhang Bo;Zhang Yongmin;Zhang Lihe;Zhou Demin;Xiao Sulong
3 Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes 期刊论文 Li M.;Yuan L.;Chen Y.;Ma W.;Ran F.;Zhang L.;Zhou D.;Xiao S.
4 Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates 期刊论文 Li Haiwei;Li Man;Xu Renyang;Wang Shouxin;Zhang Yongmin;Zhang Lihe;Zhou Demin;Xiao Sulong
5 Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis 期刊论文 Han Wang;Renyang Xu;Shuobin Liang;Fuxiang Ran;Lihe Zhang;Yongmin Zhang;Demin Zhou;Sulong Xiao
6 Synthesis and structure-activity relationship studies of water-soluble beta-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents 期刊论文 Liang Shuobin;Li Man;Yu Xiaojuan;Jin Hongwei;Zhang Yongmin;Zhang Lihe;Zhou Demin;Xiao Sulong
7 Facile preparation and characterization of novel oleanane-type triterpene functionalized beta-cyclodextrin conjugates 期刊论文 Jiao Pingxuan;Wang Shouxin;Liang Shuobin;Li Man;Gao Qianqian;Ji Dezhong;Chen Yingying;Li Haiwei;Ran Fuxiang;Zhang Yongmin;Zhang Lihe;Zhou Demin;Xiao Sulong
8 分子动力学模拟分析巴利昔冻干保护剂的活性保护机制. 期刊论文 俞小娟;于传飞;房森彪;王兰
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