高分子纳米药物的表面特性控制及其对细胞免疫功能的干预

51633008
2016
E0308.生物医用有机高分子材料
王均
重点项目
教授
华南理工大学
295万元
生物材料;生物医用高分子;纳米载体;免疫疗法;药物递送
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种蒽醌类药物和核酸复合物纳米递送体系及其制备方法与应用 专利 杨显珠;许维嘉;陈森飚;李冬冬;都小姣;王均
2 用于多特异性抗体递送的蛋白型纳米颗粒及其应用、制备方法 专利 王均;曹志婷;沈松;叶倩妮;都小姣;杨显珠;袁友永
3 Amplification of tumor oxidative stresses by poly(disulfide acetal) for multidrug resistance reversal 期刊论文 Qingyu Zong;Kewei Wang;Xuan Xiao;Maolin Jiang;Jisi Li;Youyong Yuan;Jun Wang
4 Tumor reoxygenation and blood perfusion enhanced photodynamic therapy using ultrathin graphdiyne oxide nanosheets 期刊论文 Wei Jiang;Zhen Zhang;Qin Wang;Jiaxiang Dou;Yangyang Zhao;Yinchu Ma;Huarong Liu;Hangxun Xu;Yucai Wang
5 一种含有脂质的SN-38聚合物胶束及其制备方法和应用 专利 王均;黄晓仪;杨显珠;杨艳芳;李洁仪
6 Ultrathin polypyrrole nanosheets via space-confined synthesis for efficient photothermal therapy in the second near-infrared window 期刊论文 Xu Wang;Yinchu Ma;Xing Sheng;Yucai Wang;Hangxun Xu
7 Systemic delivery of CRISPR/Cas9 with PEG-PLGA nanoparticles for chronic myeloid leukemia targeted therapy 期刊论文 Yang Liu;Gui Zhao;Cong-Fei Xu;Ying-Li Luo;Zi-Dong Lu;Jun Wang
8 Incorporation of a rhodamine B conjugated polymer for nanoparticle trafficking both in vitro and in vivo 期刊论文 Yan-Hua Zhu;Ji-Long Wang;Hou-Bing Zhang;Malik Ihsanullah Khan;Xiao-Jiao Du;Jun Wang
9 一种Toll样受体激动剂瑞喹莫德衍生物及其制备与应用 专利 杜金志;张尧君;段奇佳;童其松;李佳贤;王均
10 Fluorescent metallacycle-cored polymers via covalent linkage and their use as contrast agents for cell imaging 期刊论文 Mingming Zhang;Shuya Li;Xuzhou Yan;Zhixuan Zhou;Manik Lal Saha;Yu-Cai Wang;Peter J. Stanga
11 桥联的聚乙二醇-脂肪族聚酯嵌段共聚物、其制备方法、中间体和用途 专利 王均;孙春阳;许从飞;曹志婷;李洪军
12 Responsive nanocarriers as an emerging platform for cascaded delivery of nucleic acids to cancer 期刊论文 Yang Liu;Cong-Fei Xu;Shoaib Iqbal;Xian-Zhu Yang;Jun Wang
13 Nanoenabled modulation of acidic tumor microenvironment reverses anergy of infiltrating T cells and potentiates anti-PD-1 therapy 期刊论文 Yu-Xue Zhang;Yang-Yang Zhao;Jizhou Shen;Xun Sun;Yi Liu;Hang Liu;Yucai Wang;Jun Wang
14 Dually regulating the proliferation and the immune microenvironment of melanoma via nanoparticle-delivered siRNA targeting onco-immunologic CD155 期刊论文 Yan Wang;Ying-Li Luo;Yi-Fang Chen;Zi-Dong Lu;Yue Wang;Anna Czarna;Song Shen;Cong-Fei Xu;Jun Wang
15 Investigation of the in vivo integrity of polymeric micelles via large Stokes shift fluorophore-based FRET 期刊论文 Houbing Zhang;Hongjun Li;Zhiting Cao;Jinzhi Du;Lifeng Yan;Jun Wang
16 Bioinspired and biomimetic delivery platforms for cancer vaccines 期刊论文 Jing Liu;Si Si Liew;Jun Wang;Kanyi Pu
17 Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs 期刊论文 Wei Jiang;Jilong Wang;Jinbin Yang;Zhiwei He;Zhenhui Hou;Yingli Luo;Li Wang;Jing Liu;Houbing Zhang;Yangyang Zhao;Guoqing Zhang;Fang Huang;Xuechang Zhou;Lifeng Yan;Xianzhu Yang;Yucai Wang;Jun Wang
18 A micellar cisplatin prodrug simultaneously eliminates both cancer cells and cancer stem cells in lung cancer 期刊论文 Yan-Hua Zhu;Chun-Yang Sun;Song Shen;Malik I. U. Khan;Yang-Yang Zhao;Yang Liu;Yu-Cai Wang;Jun Wang
19 Nanoenabled reversal of IDO1-mediated immunosuppression synergizes with immunogenic chemotherapy for improved cancer therapy 期刊论文 Hua Huang;Cheng-Tao Jiang;Song Shen;An Liu;Yun-Jiu Gan;Qi-Song Tong;Sen-Biao Chen;Zhu-Xin Gao;Jin-Zhi Du;Jie Cao;Jun Wang
20 pH响应性破膜高分子材料及其制备方法与应用 专利 熊梦华;鲍燕;黄良琪;王晓川;刘明冬;梁阳彬;王均
21 改性PAMAM聚合物在制备抗肿瘤药物中的应用温敏水凝胶及其制备与应用 专利 杜金志;童其松;黄华;缪玮珉;陈阳;刘容;王均
22 A transistor-like pH-sensitive nanodetergent for selective cancer therapy 期刊论文 Mingdong Liu;Liangqi Huang;Weinan Zhang;Xiaochuan Wang;Yuanyuan Geng;Yuhao Zhang;Li Wang;Wenbin Zhang;Yun-Jiao Zhang;Shiyan Xiao;Yan Bao;Menghua Xiong;Jun Wang
23 Hierarchical multiplexing nanodroplets for imaging-guided cancer radiotherapy via DNA damage enhancement and concomitant DNA repair prevention 期刊论文 Wei Jiang;Quan Li;Liang Xiao;Jiaxiang Dou;Yi Liu;Wenhao Yu;Yinchu Ma;Xiaoqiu Li;Ye-Zi You;Zhuting Tong;Hang Liu;Hui Liang;Ligong Lu;Xiaoding Xu;Yandan Yao;Guoqing Zhang;Yucai Wang;Jun Wang
24 Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy 期刊论文 Chengtao Jiang;Kaige Chen;An Liu;Hua Huang;Yanan Fan;Dongkun Zhao;Qianni Ye;Houbing Zhang;Congfei Xu;Song Shen;Menghua Xiong;Jinzhi Du;Xianzhu Yang;Jun Wang
25 Dipole orientation matters: Longer-circulating choline phosphate than phosphocholine liposomes for enhanced tumor targeting 期刊论文 Shuya Li;Feng Wang;Xiaoqiu Li;Jing Chen;Xiaohan Zhang;Yucai Wang;Juewen Liu
26 Voluntary-opsonization-enabled precision nanomedicines for inflammation treatment 期刊论文 Shuya Li;Min Li;Shaohu Huo;Qin Wang;Jing Chen;Shenggang Ding;Zhutian Zeng;Wenchao Zhou;Yucai Wang;Jun Wang
27 Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation 期刊论文 Yang Liu;Zhi-Ting Cao;Cong-Fei Xu;Zi-Dong Lu;Ying-Li Luo;Jun Wang
28 Spatial targeting of tumor-associated macrophages and tumor cells with a pH-sensitive cluster nanocarrier for cancer chemoimmunotherapy 期刊论文 Song Shen;Hong-Jun Li;Kai-Ge Chen;Yu-Cai Wang;Xian-Zhu Yang;Zhe-Xiong Lian;Jin-Zhi Du;Jun Wang
29 The effect of surface charge on oral absorption of polymeric nanoparticles 期刊论文 Xiao-Jiao Du;Ji-Long Wang;Shoaib Iqbal;Hong-Jun Li;Zhi-Ting Cao;Yu-Cai Wang;Jin-Zhi Du;Jun Wang
30 活性氧自由基响应的多粘菌素前药化合物及其应用 专利 熊梦华;鲍燕;邓映雪;黄芮;黄松音;王均
31 Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention 期刊论文 Min Li;Ya-Nan Fan;Zhi-Yao Chen;Ying-Li Luo;Yu-Cai Wang;Zhe-Xiong Lian;Cong-Fei Xu;Jun Wang
32 Pseudoneutrophil cytokine sponges disrupt myeloid expansion and tumor trafficking to improve cancer immunotherapy 期刊论文 Shuya Li;Qin Wang;Yanqiong Shen;Muhammad Hassan;Jizhou Shen;Wei Jiang;Yitan Su;Jing Chen;Li Bai;Wenchao Zhou;Yucai Wang
33 In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance 期刊论文 Yue Zhang;Song Shen;Gui Zhao;Cong-Fei Xu;Hou-Bing Zhang;Ying-Li Luo;Zhi-Ting Cao;Jia Shi;Zhi-Bin Zhao;Zhe-Xiong Lian;Jun Wang
34 Macrophage-specific in vivo gene editing using cationic lipid-assisted polymeric nanoparticles 期刊论文 Ying-Li Luo;Cong-Fei Xu;Hong-Jun Li;Zhi-Ting Cao;Jing Liu;Ji-Long Wang;Xiao-Jiao Du;Xian-Zhu Yang;Zhen Gu;Jun Wang
35 ROS-sensitive biomimetic nanocarriers modulate tumor hypoxia for synergistic photodynamic chemotherapy 期刊论文 Hang Liu;Wei Jiang;Qin Wang;Lifeng Hang;Yucai Wang;Yanmei Wang
36 Ultrafast charge-conversional nanocarrier for tumor-acidity-activated targeted drug elivery 期刊论文 Jing Liu;Shoaib Iqbal;Xiao-Jiao Du;Youyong Yuan;Xianzhu Yang;Hong-Jun Li;Jun Wang
37 联合递送化疗药物和免疫检查点抗体药物的纳米颗粒 专利 王均;廖雨琪;沈松;赵东坤;叶倩妮
38 Nanoclustered cascaded enzymes for targeted tumor starvation and deoxygenation-activated chemotherapy without systemic toxicity 期刊论文 Yinchu Ma;Yangyang Zhao;Naveen Kumar Bejjanki;Xinfeng Tang;Wei Jiang;Jiaxiang Dou;Malik Ihsanullah Khan;Qin Wang;Jinxing Xia;Hang Liu;Ye-Zi You;Guoqing Zhang;Yucai Wang;Jun Wang
39 Rational designs of in vivo CRISPR-Cas delivery systems 期刊论文 Cong-Fei Xu;Guo-Jun Chen;Ying-Li Luo;Yue Zhang;Gui Zhao;Zi-Dong Lu;Anna Czarna;Zhen Gu;Jun Wang
40 Nanoparticle-delivered siRNA targeting Bruton's tyrosine kinase for rheumatoid arthritis therapy 期刊论文 Gui Zhao;An Liu;Yue Zhang;Zu-Qi Zuo;Zhi-Ting Cao;Hou-Bing Zhang;Cong-Fei Xu;Jun Wang
41 Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases 期刊论文 Congfei Xu;Zidong Lu;Yingli Luo;Yang Liu;Zhiting Cao;Song Shen;Hongjun Li;Jing Liu;Kaige Chen;Zhiyao Chen;Xianzhu Yang;Zhen Gu;Jun Wang
42 Simultaneous elimination of cancer stem cells and bulk cancer cells by cationic-lipid-assisted nanoparticles for cancer therapy 期刊论文 Kaige Chen;Song Shen;Gui Zhao;Zhiting Cao;Xianzhu Yang;Jun Wang
43 一种siRNA和抗癌药物疏水性复合物及其制备方法与应用 专利 杨显珠;张玉喜;王均;李冬冬;许从飞
44 Intercellular delivery of bioorthogonal chemical receptors for enhanced tumor targeting and penetration 期刊论文 Yalan Tu;Yansong Dong;Kewei Wang;Song Shen;Youyong Yuan;Jun Wang
45 重组融合蛋白、纳米组装体及其制备方法和应用 专利 王均;范亚楠;沈松;叶倩妮;刘珂;唐世帆
46 Intratumor performance and therapeutic efficacy of PAMAM dendrimers carried by clustered nanoparticles 期刊论文 Hong-Jun Li;Jing Liu;Ying-Li Luo;Sen-Biao Chen;Rong Liu;Jin-Zhi Du;Jun Wang
47 Surface charge tunable nanoparticles for TNF-α siRNA oral delivery for treating ulcerative colitis 期刊论文 Shoaib Iqbal;Xiaojiao Du;Jilong Wang;Hongjun Li;Youyong Yuan;Jun Wang
48 Enzyme degradable hyperbranched polyphosphoester micellar nanomedicines for NIR imaging-guided chemo-photothermal therapy of drug-resistant cancers 期刊论文 Mengqun Yao;Yinchu Ma;Hang Liu;Malik Ihsanullah Khan;Song Shen;Shuya Li;Yangyang Zhao;Yi Liu;Guoqing Zhang;Xiaoqiu Li;Fei Zhong;Wei Jiang;Yucai Wang
49 Enhanced primary tumor penetration facilitates nanoparticle draining into lymph nodes after systemic injection for tumor metastasis inhibition 期刊论文 Jing Liu;Hong-Jun Li;Ying-Li Luo;Cong-Fei Xu;Xiao-Jiao Du;Jin-Zhi Du;Jun Wang
50 Microenvironment-activated nanoparticles for oxygen self-supplemented photodynamic cancer therapy 期刊论文 Hang Liu;Wei Jiang;Qin Wang;Jinxing Xia;Wenhao Yu;Yucai Wang;Yanmei Wang
51 An all-in-one nanomedicine consisting of CRISPR-Cas9 and an autoantigen peptide for restoring specific immune tolerance 期刊论文 Ying-Li Luo;Li-Fang Liang;Yun-Jiu Gan;Jing Liu;Yue Zhang;Ya-Nan Fan;Gui Zhao;Anna Czarna;Zi-Dong Lu;Xiao-Jiao Du;Song Shen;Cong-Fei Xu;Zhe-Xiong Lian;Jun Wang
52 Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression 期刊论文 Senbiao Chen;Dongdong Li;Xiaojiao Du;Xinyu He;Mengwen Huang;Yang Wang;Xianzhu Yang;Jun Wang
53 结直肠癌类器官的培养方法和培养液 专利 王均;甘丽琴;陈安娜;沈松;梁洁;唐世帆
54 Cancer chemoradiotherapy duo: Nano-enabled targeting of DNA lesion formation and DNA damage response 期刊论文 Wei Jiang;Quan Li;Zhengchun Zhu;Qin Wang;Jiaxiang Dou;Yingming Zhao;Weifu Lv;Fei Zhong;Yandan Yao;Guoqing Zhang;Hang Liu;Yucai Wang;Jun Wang
55 Delivery of tacrolimus with cationic lipid-assisted nanoparticles for ulcerative colitis therapy 期刊论文 Ji-Long Wang;Yun-Jiu Gan;Shoaib Iqbal;Wei Jiang;You-Yong Yuan;Jun Wang
56 Dual-functional super bispecific nano-antibodies derived from monoclonal antibodies potentiate the antitumor effect of innate immune cells 期刊论文 Kai-Ge Chen;An Liu;Cheng-Tao Jiang;Dong-Kun Zhao;Qian-Ni Ye;Yu-Qi Liao;Cong-Fei Xu;Song Shen;Jun Wang
57 一种核酸转运用载体组合物及其在制备小干扰RNA药物中的应用 专利 王均;章望成;杨显珠
58 Biomaterials-based delivery of therapeutic antibodies for cancer therapy 期刊论文 Qian-Ni Ye;Yue Wang;Song Shen;Cong-Fei Xu;Jun Wang
59 Programmable delivery of immune adjuvant to tumor-infiltrating dendritic cells for cancer immunotherapy 期刊论文 Jing Liu;Hong-Jun Li;Ying-Li Luo;Yi-Fang Chen;Ya-Nan Fan;Jin-Zhi Du;Jun Wang
60 用于多特异性抗体递送的纳米适配子及其应用、构建方法 专利 沈松;王均;江澄涛;许从飞;杨显珠
61 A reloadable self-healing hydrogel enabling diffusive transport of C-dots across gel–gel interface for scavenging reactive oxygen species 期刊论文 Jing Chen;Shuya Li;Ye Zhang;Wei Wang;Xiang Zhang;Yangyang Zhao;Yucai Wang;Hong Bi
62 Controlled syntheses of well-defined poly(thionophosphoester)s that undergo peroxide-triggered degradation 期刊论文 Yi Liu;Naveen Kumar Bejjanki;Wei Jiang;Yangyang Zhao;Li Wang;Xun Sun;Xinfeng Tang;Hang Liu;Yucai Wang
63 Co-delivery of phagocytosis checkpoint silencer and stimulator of interferon genes agonist for synergetic cancer immunotherapy 期刊论文 Zi-Dong Lu;Yi-Fang Chen;Song Shen;Cong-Fei Xu;Jun Wang
64 一种叠氮基团改性的Janus纳米粒子及其制备方法与应用 专利 杜金志;张亚茹;黄秋月;罗佳琪;时霄霄;李佳贤;王均
65 Tumor-acidity-cleavable maleic acid amide (TACMAA): A powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine 期刊论文 Jin-Zhi Du;Hong-Jun Li;Jun Wang
66 多种免疫调节药物的载药系统及其制备方法、应用 专利 王均;李慧晓;许从飞;罗英丽
67 用于多特异性抗体递送的细胞膜包覆型纳米适配子及应用 专利 王均;罗英丽;许从飞;沈松;黄华;曹志婷
68 The effect of surface poly(ethylene glycol) length on in vivo drug delivery behaviors of polymeric nanoparticles 期刊论文 Ji-Long Wang;Xiao-Jiao Du;Jin-Xian Yang;Song Shen;Hong-Jun Li;Ying-Li Luo;Shoaib Iqbal;Cong-Fei Xu;Xiao-Dong Ye;Jie Cao;Jun Wang
69 Development of “CLAN” nanomedicine for nucleic acid therapeutics 期刊论文 Cong-Fei Xu;Shoaib Iqbal;Song Shen;Ying-Li Luo;Xianzhu Yang;Jun Wang
70 Protein binding affinity of polymeric nanoparticles as a direct indicator of their pharmacokinetics 期刊论文 Zhi-Ting Cao;Li-Qin Gan;Wei Jiang;Ji-Long Wang;Hou-Bing Zhang;Yue Zhang;Yucai Wang;Xianzhu Yang;Menghua Xiong;Jun Wang
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