小G蛋白Ral抑制剂的发现、优化及其在非小细胞肺癌中的靶点验证
21877060
2018
B0706.药物化学生物学
闫超
面上项目
教授
南京大学
68万元
先导化合物发现;靶标验证;作用机制;别构抑制剂;结构优化
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47 | 期刊论文 | Huanhuan Hu;Rongjie Cheng;Yanbo Wang;Xiaojun Wang;Jianzhuang Wu;Yan Kong;Shoubin Zhan;Zhen Zhou;Hongyu Zhu;Ranran Yu;Gaoli Liang;Qingyan Wang;Xiaoju Zhu;Chen-Yu Zhang;Rong Yin;Chao Yan;Xi Chen |
| 2 | RAL功能及其靶向药物的研究进展 | 期刊论文 | 徐乔亮;张雅亮;闫超;赖宜生 |
| 3 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics | 期刊论文 | Fu Zheng;Zhang Xiang;Zhou Xinyan;Ur-Rehman Uzair;Yu Mengchao;Liang Hongwei;Guo Hongyuan;Guo Xu;Kong Yan;Su Yuanyuan;Ye Yangyang;Hu Xiuting;Cheng Wei;Wu Jinrong;Wang Yanbo;Gu Yayun;Lu Sheng-Feng;Wu Dianqing;Zen Ke;Li Jing;Yan Chao;Zhang Chen-Yu;Chen Xi |
| 4 | A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers | 期刊论文 | Rongjie Cheng;Fanying Li;Maolei Zhang;Xin Xia;Jianzhuang Wu;Xinya Gao;Huangkai Zhou;Zhi Zhang;Nunu Huang;Xuesong Yang;Yaliang Zhang;Shunli Shen;Tiebang Kang;Zexian Liu;Feizhe Xiao;Hongwei Yao;Jianbo Xu;Chao Yan;Nu Zhang |
| 5 | Design, synthesis, and evaluation of 4(1H)-quinolinone and urea derivatives as KRASG12C inhibitors with potent antitumor activity against KRAS-mutant non-small cell lung cancer | 期刊论文 | Rongjie Cheng;Xiashi Lv;Huagang Bu;Qiaoliang Xu;Jianzhuang Wu;Kexin Xie;Jiaqi Tang;Lei Wang;Jian Zhuang;Yihua Zhang;Yaliang Zhang;Chao Yan;Yisheng Lai |
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