寡糖化合物的合成研究：方法及应用

20732001
2007
B0703.天然产物化学生物学
叶新山
重点项目
教授
北京大学
180万元
合成;糖缀合物;寡糖;糖基化
2008-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Total synthesis of solamargine 期刊论文
2 A carbohydrate modified fluoride ion sensor and its applications 期刊论文
3 The (-directing effect of ionic liquid in mannopyranosylation: a potential access to stereoselective construction of the 1, 2-cis-(-D-mannopyranosyl linkage 期刊论文
4 O,O-Dimethylthiophosphonosulfenyl Bromide-Silver Triflate: A New Powerful Promoter System for the Preactivation of Thioglycosides 期刊论文
5 Selective cleavage of sugar anomeric O-acyl groups using FeCl3-6H2O 期刊论文
6 Synthesis and anti-tumor activities of 5-carbohydrate modified cyclophosphamide derivates 期刊论文
7 Protecting Groups in Carbohydrate Chemistry: Influence on Stereoselectivity of Glycosylations 期刊论文
8 Efficient and selective removal of chloroacetyl group promoted with tetra-n-butylammonium fluoride (TBAF) 期刊论文
9 3, 4-O-Isopropylidene-2, 7-di-O-P- tolylsulfonyl- (-L-xylo-3-heptulo-3, 6-furanosononotrile 期刊论文
10 Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine donors 期刊论文
11 Synthesis and in Vitro Anti-Hepatitis B Virus Activity of Six-Membered Azanucleoside Analogues 期刊论文
12 Synthesis of neamine-carboline conjugates for RNA binding and their antibacterial activities 期刊论文
13 Stereoselective Total Synthesis of (-)-Cleistenolide 期刊论文
14 Synthesis and Crystal structure of (1R,2S,3S,4S)-(6-O-acetyl-1,2-O-isoproplidene-3,5-dideoxy-(-D-glucofuranoso)-1,3,5-trihydro-2,3-oxathiaindene-2,2-dioxide 期刊论文
15 Sialylation reactions with N, N-acetyl, benzoyl-O-perbenzoyl-protected sialyl donor 期刊论文
16 Synthesis of 3-N-sugar- substituted-2, 4 (1H, 3H)-quinazolinediones as anti-angiogenesis agents 期刊论文
17 A highly α-selective glycosylation for the convenient synthesis of repeating α-1→4 linked N-acetyl-galactosamine units 期刊论文
18 Methyl 2,3-di-O-acetyl-4-O-levulinoyl-1-O-(2,2,2,-trichloro-2-iminoethyl)-L-idopyranosiduronate 期刊论文
19 Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu 期刊论文
20 Facile synthesis of a core trisaccharide of laminin as a potential metastatic antagonist 期刊论文
21 Total synthesis of apigenin-4’-yl 2- O-(p-coumaroyl)-(-D-glucopyranoside 期刊论文
22 Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains 期刊论文
23 NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity 期刊论文
24 Assembly of Homolinear α(1→2)-Linked Nonamannoside on Ion Liquid Support 期刊论文
25 Microwave-assisted efficient synthesis of glucose-based 3-acetyl-5-alkyl-2, 3-dihydro-1, 3, 4-oxadiazole derivatives catalyzed by sodium acetate 期刊论文
26 Synthesis of stryphnoside A, a triterpene saponin isolated from the pericarps of Stryphnodendron fissuratum 期刊论文
27 Rational Design and Synthesis of Potent Aminoglycoside Antibiotics against Resistant Bacterial Strains 期刊论文
28 Synthesis of allyl 4-O-{3-deoxy-3-[4-benzylaminocarbonyl-1H-(1, 2, 3)-triazol-1-yl]-(-galactopyranpsyl}-2-deoxy- acetamido-(-D-glucopyranoside as a potential inhibitor of galectin-3 期刊论文
29 FeCl3-catalyzed (-glycosidation of glycosamine pentaacetates 期刊论文
30 A Highly Efficient and Mild Method for Regioselective de-O-benzylation of Saccharides by Co2(CO)8-Et3SiH-CO Reagent System 期刊论文
31 Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen 期刊论文
32 Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-Glycosides 期刊论文
33 Additive-Controlled Stereoselective Glycosylations of Oxazolidinone Protected Glucosamine and Galactosamine Thioglycoside Donors Based on Preactivation Protocol 期刊论文
34 Stereoselectivity investigation on glycosylation of oxazolidinone protected 2-amino-2-deoxy-D-glucose donors based on pre-activation protocol 期刊论文
35 Highly Direct α-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy and 2,6-Dideoxythioglycosides by Preactivation Protocol 期刊论文
36 Stereoselective Synthesis of 2-Deoxy-Pyranosides via the Lewis Acid-Promoted Rearrangement of 2,3-Anhydrosugars 期刊论文
37 Synthesis of S-linked tumor-associated carbohydrate antigen STn 期刊论文
38 Regio- and Stereo-Selective Synthesis of Aryl 2-Deoxy-C-Glycopyranosides by Palladium-Catalyzed Heck Coupling Reactions of Glycals and Aryl Iodides 期刊论文
39 糖化学和基于糖的药物研究 奖励
40 Diastereoselective Diacetoxylation of Alkenes Mediated by PhI(OAc)2/BF3?OEt2 System 期刊论文
41 An Active Cobalt Catalyst for the Cleavage of Benzyl Ether, 期刊论文
42 Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles 期刊论文
43 An alternative total synthesis of solamargine 期刊论文
44 New rhodamine derivative as OFF-ON fluorescent chemosensor for detection of Cu2+ 期刊论文
45 Total synthesis of a furostan saponin, timosaponin BII 期刊论文
46 基于糖类的药物先导化合物的发现和优化研究 奖励
47 Efficient synthesis of a series of novel fructose-based 3-acetyl-5-alkyl-2, 3-dihydro- 1,3,4-oxadiazole derivatives and studies of the reaction mechanism 期刊论文
48 Crystal Structures of Streptococcus suis Mannonate Dehydratase (ManD) and Its Complex with Substrate: Genetic and Biochemical Evidence for a Catalytic Mechanism 期刊论文
49 Synthesis of α-C-Glycosides by Samarium Diiodide Mediated Coupling of Glycosyl Pyridyl Sulfones with Alkenes 期刊论文
50 A Highly α-Stereoselective Synthesis of Oligosaccharide Fragments of Vi Antigen from Salmonella typhi and Their Antigenic Activities 期刊论文
51 Direct α-Selective Glycosylations of Acetyl-Protected 2-Deoxy and 2,6-Dideoxythioglycosides by Preactivation Protocol 期刊论文
52 Bromodimethylsulfonium bromide-silver triflate: a new powerful promoter system for the activation of thioglycosides 期刊论文
53 Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of STn antigen 期刊论文
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