新型异戊烯基二氢黄酮类组织蛋白酶K抑制剂的结合位点确证及其抗骨质疏松作用机制研究

81903618
2019
H3503.老年病药物药理
邱佐成
青年科学基金项目
副教授
暨南大学
21万元
异戊烯基二氢黄酮;exosite 1抑制剂;组织蛋白酶K;骨质疏松症;骨吸收
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 异戊烯基二氢黄酮类化合物在防治骨疾病领域的应用 专利 黄文秀;姚新生;邱佐成;董晓莉;戴毅
2 8-prenylgenistein exerts osteogenic effects via ER alpha and Wnt-dependent signaling pathway 期刊论文 Qiu Zuo-cheng;Zhang Yan;Xiao Hui-hui;Poon Christina-chui-wa;Li Xiao-li;Cui Jian-fang;Wong Man-kin;Yao Xin-sheng;Wong Man-sau
3 Dissection of the potential pharmacological mechanism of Rhizoma coptidis water extract against inflammation in diabetes mellitus via chemical profiling, network pharmacology and experimental validation 期刊论文 Zhang Feng-xiang;Li Min;Yuan Yu-lin-lan;Cui Shuang-Shuang;Qiu Zuo-cheng;Li Rui-man
4 Genistein Modified with 8-Prenyl Group Suppresses Osteoclast Activity Directly via Its Prototype but Not Metabolite by Gut Microbiota 期刊论文 Zuocheng Qiu;Fengxiang Zhang;Xueling Hu;Yangyang Zhang;Ziling Tang;Jie Zhang;Li Yang;Mansau Wong;Jiaxu Chen;Huihui Xiao
5 A new strategy for discovering effective substances and mechanisms of traditional Chinese medicine based on standardized drug containing plasma and the absorbed ingredients composition, a case study of Xian-Ling-Gu-Bao capsules 期刊论文 Qiu Zuo-cheng;Tang Xi-yang;Wu Qing-chang;Tang Zi-ling;Wong Man-sau;Chen Jia-xu;Yao Xin-sheng;Dai Yi
6 一种包含C21甾体皂苷的药物组合物及其应用 专利 邱佐成;陈家旭;唐紫灵;庞倩倩;鄢黎
7 A novel strategy for exploring food originated anti-adipogenesis substances and mechanism by structural similarity evaluation, ADME prediction, network pharmacology and experimental validation 期刊论文 Zhang Feng-xiang;Tang Zi-ling;Qiu Zuo-cheng
8 木兰花碱在制备骨调节药物增效剂中的应用及包含木兰花碱的药物组合物 专利 戴毅;唐曦阳;吴清昌;邱佐成;肖辉辉;黄文秀;姚新生
9 Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway 期刊论文 Qiu Zuo-cheng;Li Ling;Huang Yu-ying;Shi Ke-da;Zhang Li-zhong;Huang Cui-shan;Liang Jie-chao;Zeng Qing-qiang;Wang Jia-li;He Xiang-jiu;Qin Ling;Wang Xin-luan
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