aFGF改构体调控GSK3β磷酸化及其靶标分子治疗AD的分子机制

81373313
2013
H3404.生物技术药物
黄亚东
面上项目
研究员
暨南大学
75万元
阿尔茨海默病;糖元合成酶3β;酸性成纤维细胞生长因子
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors 期刊论文 Yang Yan;Li Ziyi;Wu Xupeng;Chen Haolin;Xu Wenting;Xiang Qi;Zhang Qihao;Chen Jie;Ge Ren-Shan;Su Zhijian;Huang Yadong
2 Evaluation of the Safety and Brain-Related Tissues Distribution Characteristics of TAT-HaFGF via intranasal Administration 期刊论文 Xu Jinmei;Xiang Qi;Su Junhui;Yang Penghui;Zhang Qihao;Su Zhijian;Xiao Fei;Huang Yadong
3 Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals 期刊论文 Ji Xunmin;Li Zhiliang;Chen Hongxia;Li Junqi;Tian Huajian;Li Zengli;Gao Xuejuan;Xiang Qi;Su Zhijian;Huang Yadong;Zhang Qihao
4 Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1alpha/XBP1 Pathway. 期刊论文 Meng Tian;Cao Qin;Lei Peng;Bush Ashley I;Xiang Qi;Su Zhijian;He Xiang;Rogers Jack T;Chiu Ing-Ming;Zhang Qihao;Huang Yadong
5 Intranasal TAT-haFGF Improves Cognition and Amyloid-beta Pathology in an A beta PP/PS1 Mouse Model of Alzheimer's Disease 期刊论文 Lou Guofeng;Zhang Qihao;Xiao Fei;Xiang Qi;Su Zhijian;Huang Yadong
6 Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3 beta Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease 期刊论文 Yang Peng-hui;Zhu Jian-xiu;Huang Ya-dong;Zhang Xian-ying;Lei Peng;Bush Ashley I.;Xiang Qi;Su Zhi-jian;Zhang Qi-hao
7 一种预防和治疗神经退行性疾病的新型脑部靶向制剂 专利 黄亚东;项琪;张齐好;苏志坚;郑青
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