原位肝胆系转化在非酒精性脂肪性肝病肝纤维化启动过程中的作用及其机制研究

81670522
2016
H0307.肝脏代谢障碍及相关疾病
汪艳
面上项目
教授
南方医科大学
55万元
肝纤维化;胆管反应;肝小叶分区;非酒精性脂肪性肝病;肝再生
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 土三七致肝窦阻塞综合征的发生机制与临床诊治研究进展 期刊论文 李世英;汪艳
2 脂肪性肝病诊断新进展 会议论文 汪艳
3 肝纤维化研究进展 会议论文 汪艳
4 欧洲临床实践指南制定流程的时效性与质量推进双要素 期刊论文 汪艳
5 Activation of hepatocyte nuclear factor 4 alpha promotes in vitro hepatic repolarization 期刊论文 Yang Jinlian;Wang Yan
6 评估脂肪肝:有创还是无创? 会议论文 汪艳
7 临床肝胆疾病相关的胆管反应及其意义 期刊论文 郑永见;汪艳
8 早期生长反应蛋白1参与肝病发生主要病理机制研究进展 期刊论文 曾伟兰;汪艳
9 转录组测序分析NASH早期YAP阳性表达肝细胞的功能学特征 期刊论文 曾伟兰;梁嘉恩;刘雅雪;汪艳
10 Quantification of Liver Fibrosis 会议论文 Wang Yan
11 脂肪肝组织学定量评估 会议论文 汪艳
12 Quantifying and monitoring fibrosis in non-alcoholic fatty liver disease using dual-photon microscopy 期刊论文 Wang Yan;Wong Grace Lai-Hung;He Fang-Ping;Sun Jian;Chan Anthony Wing-Hung;Yang Jinlian;Shu Sally She-Ting;Liang Xieer;Tse Yee Kit;Fan Xiao-Tang;Hou Jinlin;Chan Henry Lik-Yuen;Wong Vincent Wai-Sun
13 无创肝纤维诊断的临床研究进展 会议论文 汪艳
14 YAP-谷氨酰胺回补反应与肝纤维化发生 期刊论文 汪艳
15 Murine models for ductular reaction in chronic liver diseases 期刊论文 Chen Guangzhong;Ma Jing;Lin Jiezhao;Liao Ziyu;Wang Yan
16 抑制线粒体丙酮酸载体通过激活AMPK-ACC通路改善棕榈酸诱导的HepG2细胞脂肪变性 期刊论文 李世英;汪艳
17 Quantitative Assessment of Liver Histology and Its Implication for Clinical Study 会议论文 Wang Yan
18 Quantitative Assessment of Fibrosis Progression in Liver Histology of Nonalcoholic Steatohepatitis 会议论文 Wang Yan
19 高氨血症在肝性脑病发生中的地位 期刊论文 汪艳
20 Performance of quantitative collagen parameters for assessing longitudinal non-advanced liver fibrosis 期刊论文 Wang Yan;Liang Xieer;Sun Jian;Yang Jinlian;Zheng Yongjian;Chen Yongpeng;Hou Jinlin
21 生物组织图像的识别方法及装置 专利 汪艳;侯金林;冯前进
22 Histologic fibrosis across the natural course of chronic hepatitis B virus infection: a systematic review and meta-analysis. 期刊论文 Wang Yan;Lin Mei-Hong;Li Hai-Qiong;Zhu Lin
23 NAFLD肝纤维化全定量诊断 会议论文 汪艳
24 Systematic quantification of histological patterns shows accuracy in reflecting cirrhotic remodeling 期刊论文 Wang Yan;Huang Wei;Li Ruhua;Yun Zhaoqiang;Zhu Youfu;Yang Jinlian;Liu Hailin;Liu Zhipeng;Feng Qianjin;Hou Jinlin
25 组织学纤维化与失代偿性肝硬化预后的相关性 会议论文 汪艳
26 脂肪性肝炎肝组织纤维化相关的细胞外基质变化 期刊论文 汪艳
27 肝纤维化新型量化诊断 会议论文 汪艳
28 脂肪性肝炎相关纤维化评估的研究进展 会议论文 汪艳
29 Mechanical compaction accelerates hepatocyte repolarization by directly activating HNF4α expression 会议论文 Yang Jinlian;Liang Jiaen;Wang Yan
30 Dual photon microscopy-based quantitation of fibrosis related collagen properties (Q-FP) to model disease progression in steatohepatitis. 期刊论文 Wang Yan;Vincent Robert;Zhang Jinping;Yang Jinlian;Mirshahi Faridoddin;Sanyal Arun J
31 Improved performance of quantitative collagen parameters versus standard histology in longitudinal assessment of nonadvanced liver fibrosis for chronic hepatitis B 期刊论文 Wang Yan;Liang Xieer;Yang Jinlian;Wang Hao;Tan Deming;Chen Shijun;Cheng Jun;Chen Yongpeng;Sun Jian;Fan Rong;Yang Wei;Liu Hailin;Liu Zhipeng;Zheng Yongjian;Liang Jiaen;Li Shiying;Liu Zhihong;Hou Jinlin
32 Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4 alpha Activation 期刊论文 Yang Jinlian;Liang Jiaen;Zheng Yongjian;Li Shiying;Li Yang;Liu Haiyan;Chen Guanzhong;Ma Jing;Liao Ziyu;Lin Jiezhao;Jiang Zesheng;Wang Yan
33 一种原代肝细胞体外复极性的培养方法 专利 汪艳;杨金连
34 Dual Photon Microscopy Based Quantitation of Fibrosis-Related Parameters (q-FP) to Model Disease Progression in Steatohepatitis: Methodological Issues REPLY 期刊论文 Wang Yan;Sanyal Arun J.
35 酒精性肝病的临床无创诊断研究现状 期刊论文 汪艳
36 Yes相关蛋白参与肝脏疾病作用机制的研究进展 期刊论文 梁嘉恩;汪艳
37 脂肪性肝炎的精准临床诊断研究进展 会议论文 汪艳
38 Histologic fibrosis patterns associate with disease severity and short-term mortality in patients with acute decompensation of cirrhosis 会议论文 Wang Yan
39 Prevalence of liver fibrosis in the natural course of chronic hepatitis B virus infection: a systematic review with meta-analysis. 期刊论文 Wang Yan;Lin Meihong;Li Hai-Qiong;Zhu Lin
40 YAP Activation in Hepatocytes at Early Stage of Steatohepatitis 会议论文 Liang Jiaen;Yang Jinlian;Zheng Yongjian;Li Shiying;Wang Yan
41 超厚组织切片的制备及细胞水平再现组织 三维形态结构的方法 专利 汪艳;郑永见;潘明新;李阳
42 补体参与肝脏损伤与再生修复机制 期刊论文 汪艳
43 A prospective cohort study for analysis of safety and surgical outcomes of single-port versus standard laparoscopic hepatic left lateral lobectomy 期刊论文 Yuan Cheng;Ming-Xin Pan;Yi Gao;Ze-Sheng Jiang;Xiao-Ping Xu;Guo-Lin He;Cheng-Jie Zhou;Jia-Sheng Qin;Hai-Yan Liu;Yan Wang
44 QUANTIFYING AND MONITORING FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE USING DUAL-PHOTON MICROSCOPY 会议论文 Wang Yan;Wong Grace Lai-Hung;Sun Jian;Chan Anthony Wing-Hung;Yang Jin-Lian;Shu Sally She Ting;Liang XieEr;Tse Yee-Kit;Hou Jin-Lin;Chan Henry Lik Yuen;Wong Vincent Wai-Sun
45 有机溶质转运蛋白αβ缺陷病 期刊论文 何彩萍;汪艳
46 非酒精性脂肪性肝病:纤维化终点的评估 会议论文 汪艳
47 肝纤维化和肝硬化逆转的组织学评价 期刊论文 郑永见;汪艳
48 NASH组织学分析的临床研究进展 会议论文 汪艳
49 参与肝组织再生修复的肝细胞分布特征 期刊论文 刘雅雪;汪艳
50 用于早期肝纤维化诊断的标志物、试剂盒及用途 专利 汪艳;杨金连;何彩萍
51 生物组织影像识别的方法及其系统、计算机储存介质 专利 汪艳;侯金林;冯前进
52 YAP activation and involvement in the development of ductular reaction in pathogenesis of non-alcoholic steatohepatitis 期刊论文 Liang Jia-En;Li Shi-Ying;Zeng Wei-Lan;He Cai-Ping;Wang Yan
53 Dual-Photon Microscopy-Based Quantitation of Fibrosis-Related Parameters (q-FP) to Model Disease Progression in Steatohepatitis 期刊论文 Wang Yan;Vincent Robert;Yang Jinlian;Asgharpour Amon;Liang Xieer;Idowu Michael O.;Contos Melissa J.;Daitya Kalyani;Siddiqui Mohammed S.;Mirshahi Faridoddin;Sanyal Arun J.
54 非酒精性脂肪性肝病相关肝纤维化及其组织学量化分析 期刊论文 汪艳;侯金林
55 Systematic quantitation of fibrosis and cirrhotic pattern 会议论文 Wang Yan
56 Quantitative Assessment of Histologic Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease 会议论文 Wang Yan
57 肝纤维化全定量分析在临床和新药研发的应用 会议论文 汪艳
58 Automated quantitation of cirrhotic patterns showing the excellent accuracy in reflecting the pathophysiologic evolution and disease severity in cirrhotic animal model and chronic hepatitis B liver biopsies 会议论文 Wang Yan;Feng Qianjin;Huang Wei;Yang Jinlian;Liu Hailin;Hou Jinlin
59 Analysis of a 10-year clinical spectrum of biliary diseases referral to a Chinese Tertiary Medical Center 期刊论文 Lin Meihong;Su Zhihua;Zhang Feng;Liu Ziming;Jiang Zesheng;Wang Yan
60 Quantitative collagen pattern has independent prognostic value in predicting short-term survival in cirrhosis patients with acute decompensation 期刊论文 Wang Yan;Bihari Chhagan;Rastogi Archana;Hou Jin-Lin;Sarin Shiv V
61 慢加急性肝衰竭肝组织再生的实验研究 期刊论文 汪艳
62 调控自噬在临床肝病治疗性应用的转化研究 期刊论文 汪艳
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