营养感应信号mTORC1促进软骨衰老及其调控机制
81530070
2015
H06.运动系统
白晓春
重点项目
教授
南方医科大学
274万元
软骨衰老;雷帕霉素靶蛋白;泛素化;营养感应信号;FBW7
2016-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury. | 期刊论文 | Shen J;Cui ZK;Yao F;Li K;Zhang Y;Chen Z;Zhou Y;Xu S;Zhang Y;Jiang W;Zhang H;Tan K;Liu A;Bai X |
| 2 | DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes. | 期刊论文 | Kai Li;Panpan Yang;Yuwei Zhang;Yue Zhang;He Cao;Peilin Liu;Bin Huang;Song Xu;Pinglin Lai;Guanghua Lei;Jia Liu;Yujin Tang;Xiaochun Bai;Zhipeng Zou |
| 3 | Macrophages regulate the progression of osteoarthritis | 期刊论文 | Zhang Haiyan;Cai Daozhang;Bai Xiaochun |
| 4 | Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation. | 期刊论文 | Miao Liu;Ling Zhou;Baiyu Zhang;Minhong He;Xiaoying Dong;Xiaojun Lin;Chunhong Jia;Xiaochun Bai;Yifan Dai;Yongchun Su;Zhipeng Zou;Hang Zheng |
| 5 | mTORC1 Inhibits NF-kappa B/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice | 期刊论文 | Zhang Yue;Xu Song;Li Kai;Tan Kang;Liang Kangyan;Wang Jian;Shen Junhui;Zou Wenchong;Hu Le;Cai Daozhang;Ding Changhai;Li Mangmang;Xiao Guozhi;Liu Bin;Liu Anling;Bai Xiaochun |
| 6 | 一种miRNA-483-5P抑制剂药物及其在治疗骨关节炎药物中的用途 | 专利 | 白晓春;王华;张海严;孙秋怡;蔡道章 |
| 7 | mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. | 期刊论文 | Yang Jun;Zhou Xuan;Fan Xiaorong;Xiao Min;Yang Dinghua;Liang Bo;Dai Meng;Shan Lanlan;Lu Jingbo;Lin Zhiqi;Liu Rong;Liu Jun;Wang Liping;Zhong Mei;Jiang Yu;Bai Xiaochun |
| 8 | Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice | 期刊论文 | Yang Cheng;Chen Yuhui;Li Zhen;Cao He;Chen Keming;Lai Pinglin;Yan Bo;Huang Bin;Tang Jiajun;Fan Shicai;Cai Daozhang;Jin Dadi;Bai Xiaochun;Zhou Rongping |
| 9 | Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12 | 期刊论文 | Lin Chuangxin;Liu Liangliang;Zeng Chun;Cui Zhong Kai;Chen Yuhui;Lai Pinling;Wang Hong;Shao Yan;Zhang Haiyan;Zhang Rongkai;Zhao Chang;Fang Hang;Cai Daozhang;Bai Xiaochun |
| 10 | Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. | 期刊论文 | Huang Bin;Wang Wenhao;Li Qingchu;Wang Zhenyu;Yan Bo;Zhang Zhongmin;Wang Liang;Huang Minjun;Jia Chunhong;Lu Jiansen;Liu Sichi;Chen Hongdong;Li Mangmang;Cai Daozhang;Jiang Yu;Jin Dadi;Bai Xiaochun |
| 11 | Chondrocyte mTORC1 activation stimulates miR‐483‐5p via HDAC4 in osteoarthritis progression . | 期刊论文 | Wang H;Zhang H;Sun Q;Yang J;Zeng C;Ding C;Cai D;Liu A;Bai X |
| 12 | Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis. | 期刊论文 | Xiong Z;Wang C;Wang Z;Dai H;Song Q;Zou Z;Xiao B;Zhao AZ;Bai X;Chen Z |
| 13 | Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice | 期刊论文 | Lu Jiansen;Zhang Haiyan;Cai Daozhang;Zeng Chun;Lai Pinglin;Shao Yan;Fang Hang;Li Delong;Ouyang Jiayao;Zhao Chang;Xie Denghui;Huang Bin;Yang Jian;Jiang Yu;Bai Xiaochun |
| 14 | Bone and plasma citrate is reduced in osteoporosis. | 期刊论文 | Chen H;Wang Y;Dai H;Tian X;Cui ZK;Chen Z;Hu L;Song Q;Liu A;Zhang Z;Xiao G;Yang J;Jiang Y;Bai X |
| 15 | 原发性骨质疏松症的信号网络调控机制及其干预策略 | 奖励 | 陆地;白晓春;桂莉;孙林;钟莲梅;郭家智;罗深秋 |
| 16 | mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis | 期刊论文 | Zhang H.;Wang H.;Zeng C.;Yan B.;Ouyang J.;Liu X.;Sun Q.;Zhao C.;Fang H.;Pan J.;Xie D.;Yang J.;Zhang T.;Bai X.;Cai D. |
| 17 | Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes. | 期刊论文 | Zhang Yue;Xu Song;Liang Kang-Yan;Li Kai;Zou Zhi-Peng;Yang Cui-Lan;Tan Kang;Cao Xiong;Jiang Yu;Gao Tian-Ming;Bai Xiao-Chun |
| 18 | Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses. | 期刊论文 | Lin X;Sun Q;Zhou L;He M;Dong X;Lai M;Liu M;Su Y;Jia C;Han Z;Liu S;Zheng H;Jiang Y;Ling H;Li M;Chen J;Zou Z;Bai X |
| 19 | TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. | 期刊论文 | Xu S;Zhang Y;Wang J;Li K;Tan K;Liang K;Shen J;Cai D;Jin D;Li M;Xiao G;Xu J;Jiang Y;Bai X |
| 20 | Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2 | 期刊论文 | Wang Hua;Zhang Haiyan;Sun Qiuyi;Wang Yun;Yang Jun;Yang Jincheng;Zhang Tao;Luo Shenqiu;Wang Liping;Jiang Yu;Zeng Chun;Cai Daozhang;Bai Xiaochun |
| 21 | Osteoblasts support megakaryopoiesis through production of interleukin-9 | 期刊论文 | Xiao Min;Wang Yongkui;Tao Chen;Wang Zhenyu;Yang Jun;Chen Zhenguo;Zou Zhipeng;Li Mangmang;Liu Anling;Jia Chunhong;Huang Bin;Yan Bo;Lai Pinglin;Ding Changhai;Cai Daozhang;Xiao Guozhi;Jiang Yu;Bai Xiaochun |
| 22 | Exosome Release Is Regulated by mTORC1 | 期刊论文 | Zou Wenchong;Lai Mingqiang;Zhang Yue;Zheng Lei;Xing Zhe;Li Ting;Zou Zhipeng;Song Qiancheng;Zhao Xiaoyang;Xia Laixin;Yang Jian;Liu Anling;Zhang Han;Cui Zhong Kai;Jiang Yu;Bai Xiaochun |
| 23 | Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. | 期刊论文 | Zhang H;Lin C;Zeng C;Wang Z;Wang H;Lu J;Liu X;Shao Y;Zhao C;Pan J;Xu S;Zhang Y;Xie D;Cai D;Bai X |
| 24 | Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway | 期刊论文 | Li Kai;Zhang Yue;Zhang Yuwei;Jiang Wenqing;Shen Junhui;Xu Song;Cai Daozhang;Shen Jie;Huang Bin;Li Mangmang;Song Qiancheng;Jiang Yu;Liu Anling;Bai Xiaochun |
| 25 | Loss of Rictor with aging in osteoblasts promotes age-related bone loss | 期刊论文 | Lai Pinling;Song Qiancheng;Yang Cheng;Li Zhen;Liu Sichi;Liu Bin;Li Mangmang;Deng Hongwen;Cai Daozhang;Jin Dadi;Liu Anling;Bai Xiaochun |
| 26 | DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis | 期刊论文 | Ding Yan;Shan Lanlan;Nai Wenqing;Lin Xiaojun;Zhou Ling;Dong Xiaoying;Wu Hongyuan;Xiao Min;Zhou Xuejuan;Wang Linlin;Li Ting;Fu You;Lin Yijun;Jia Chunhong;Dai Meng;Bai Xiaochun |
| 27 | 慢性肾病进展的机制和临床防治 | 奖励 | 侯凡凡;蓝辉耀;刘必成;易凡;廖禹林;陈志良;宾建平;陈永现;周丽丽;白晓春 |
| 28 | Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation | 期刊论文 | Wang Yongkui;Xiao Min;Tao Chen;Chen Jing;Wang Zhenyu;Yang Jun;Chen Zhenguo;Zou Zhipeng;Liu Anling;Cai Daozhang;Jiang Yu;Ding Changhai;Li Mangmang;Bai Xiaochun |
| 29 | Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury | 期刊论文 | Wang Caixia;Dai Huaiqian;Xiong Zhi;Song Qiancheng;Zou Zhipeng;Li Mangmang;Nie Jing;Bai Xiaochun;Chen Zhenguo |
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