核受体FXR调控内源性雌激素II相代谢的作用机制研究

81903704
2019
H3510.药物代谢与药物动力学
秦子飞
青年科学基金项目
主管药师
郑州大学
21万元
外排转运蛋白;UGT/SULT酶;FXR受体;雌激素（雌二醇、雌酮和雌三醇）;代谢与处置
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule 期刊论文 Liangliang He;Chanjuan Chen;Shuyi Duan;Yang Li;Chuan Li;Xinsheng Yao;Frank J. Gonzalez;Zifei Qin;Zhihong Yao
2 Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters 期刊论文 Zifei Qin;Peile Wang;Shuyi Duan;Xiaoying Wan;Han Xing;Jing Yang;Xiaojian Zhang;Zhihong Yao;Xin-Sheng Yao
3 补骨脂定的肝肠微粒体代谢动力学、代谢酶表型及种属差异研究 期刊论文 秦子飞;张贝贝;邢晗;王培乐;杨晶;张晓坚;姚志红;姚新生
4 Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions 期刊论文 Zifei Qin;Mengmeng Jia;Jing Yang;Han Xing;Zhao Yin;Zhihong Yao;Xiaojian Zhang;Xinsheng Yao
5 UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins 期刊论文 Jia Mengmeng;Zhang Beibei;Qi Yuedong;Yang Jing;Yao Zhihong;Qin Zifei;Zhang Xiaojian;Yao Xinsheng
6 Potential metabolism determinants and drug–drug interactions of a natural flavanone bavachinin 期刊论文 Xinqiang Li;Han Xing;Zifei Qin;Jing Yang;Peile Wang;Xiaojian Zhang;Zhihong Yao;Xin-Sheng Yao
7 Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens 期刊论文 Liangliang He;Chunxia Xu;Ziying Wang;Shuyi Duan;Jinjin Xu;Chuan Li;Xinsheng Yao;Frank J. Gonzalez;Zifei Qin;Zhihong Yao
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