基于肝癌患者CYP2E1活性增高研究CYP2E1特异性抑制剂

81872931
2018
H3510.药物代谢与药物动力学
乔海灵
面上项目
教授
郑州大学
57万元
肝纤维化;CYP2E1特异性抑制剂;肝癌;亚硝胺;CYP2E1
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway 期刊论文 Wang Caie;Gao Na;Yang Lukui;Guo Yuanyuan;Fang Yan;Wang Tong;Xu Chen;Li Gui fang;Zhou Jun;Zhang Yunfei;Wen Qiang;Qiao Hailing
2 The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma. 期刊论文 Gu Yuhan;Guo Yuanyuan;Gao Na;Fang Yan;Xu Chen;Hu Guiming;Guo Mengxue;Ma Yaxing;Zhang Yunfei;Zhou Jun;Luo Yanlin;Zhang Haifeng;Wen Qiang;Qiao Hailing
3 The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. 期刊论文 Fang Yan;Yang Hongming;Hu Guiming;Lu Jiakun;Zhou Jun;Gao Na;Gu Yuhan;Zhang Cunzhen;Qiu Jinhuan;Guo Yuanyuan;Zhang Yunfei;Wen Qiang;Qiao Hailing
4 High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype 期刊论文 Guo Yuan yuan;Xu Chen;Fang Yan;Wang Cai e;Gao Na;Wen Qiang;Qiao Hai ling
5 Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D610 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker 期刊论文 Hu Guiming;Gao Fei;Wang Guanzhe;Fang Yan;Guo Yuanyuan;Zhou Jun;Gu Yuhan;Zhang Cunzhen;Gao Na;Wen Qiang;Qiao Hailing
6 Variation in the expression of cytochrome P450-related miRNAs and transcriptional factors in human livers: Correlation with cytochrome P450 gene phenotypes 期刊论文 Zhang Hai-feng;Zhu Li-li;Yang Xiao-bei;Gao Na;Fang Yan;Wen Qiang;Qiao Hai-ling
7 From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo 期刊论文 Yan Fang;Tong Wang;Yuan-Yuan Guo;Hai-Feng Zhang;Qiang Wen;Yu-Rong Xing;Na Gao;Hai-Ling Qiao
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