人肝微粒体CYP代谢药物个体差异技术平台的建立及关键基础研究
81473279
2014
H3510.药物代谢与药物动力学
乔海灵
面上项目
教授
郑州大学
70万元
个体差异;药物代谢;细胞色素P450酶;人肝微粒体
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs | 期刊论文 | Jie Gao;Jie Wang;Na Gao;Xin Tian;Jun Zhou;Yan Fang;Haifeng Zhang;Qiang Wen;Linjing Jia;Dan Zou;Hailing Qiao |
| 2 | Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes | 期刊论文 | Haifeng Zhang;Huanhuan Wang;Na Gao;Junying Wei;Xin Tian;Yan Zhao;Yan Fang;Jun Zhou;Qiang Wen;Jie Gao;Yangjun Zhang;Xiaohong Qian;Hailing Qiao |
| 3 | Effect of P450 oxidoreductase polymorphisms on the metabolic activities of ten cytochrome P450s varied by polymorphic CYP genotypes in human liver microsomes | 期刊论文 | Fang Yan;Gao Na;Tian Xin;Zhou Jun;Zhang Hai-Feng;Gao Jie;He Xiao-Pei;Wen Qiang;Jia Lin-Jing;Jin Han;Qiao Hai-Ling |
| 4 | Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver | 期刊论文 | Haifeng Zhang;Zhihui Li;Jiayu Liu;Tingting Liu;Ping Wang;Yan Fang;Jun Zhou;Mingzhu Cui;Na Gao;Xin Tian;Jie Gao;Qiang Wen;Linjing Jia;Hailing Qiao |
| 5 | Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. | 期刊论文 | Zhou Jun;Wen Qiang;Li Sai-Fei;Zhang Yun-Fei;Gao Na;Tian Xin;Fang Yan;Gao Jie;Cui Ming-Zhu;He Xiao-Pei;Jia Lin-Jing;Jin Han;Qiao Hai-Ling |
| 6 | High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines | 期刊论文 | Gao Jie;GaoJu Wang;Zhao Wang;Na Gao;Jing Li;Yunfei Zhang;Jun Zhou;HongXin Zhang;Qiang Wen;Han Jin;Hailing Qiao |
| 7 | Content and activities of UGT2B7 in human liver in vitro and predicted in vivo: a bottom-up approach | 期刊论文 | Xu Chen;Gao Jie;Zhang Hai-Feng;Gao Na;Guo Yuan-Yuan;Fang Yan;Wen Qiang;Qiao Hai-Ling |
| 8 | Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes | 期刊论文 | Zhang Haifeng;Gao Na;Liu Tingting;Fang Yan;Qi Bing;Wen Qiang;Zhou Jun;Jia Linjing;Qiao Hailing |
| 9 | Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach | 期刊论文 | Jie Gao;Jun Zhou;Xiaopei He;Yunfei Zhang;Na Gao;Xin Tian;Yan Fang;Qiang Wen;Linjing Jia;Han Jin;Hailing Qiao |
| 10 | 人肝 CYP450 酶含量与活性研究进展 | 期刊论文 | 高洁;乔海灵 |
| 11 | Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo | 期刊论文 | Zhang Haifeng;Gao Na;Tian Xin;Liu Tingting;Fang Yan;Zhou Jun;Wen Qiang;Xu Binbin;Qi Bing;Gao Jie;Li Hongmeng;Jia Linjing;Qiao Hailing |
| 12 | CYP3A4/5 activity probed with testosterone and midazolam: Correlation between two substrates at the microsomal and enzyme levels | 期刊论文 | Xiao Kang;Gao Jie;Weng Shi-Jia;Fang Yan;Gao Na;Wen Qiang;Jin Han;Qiao Hai-Ling |
| 13 | From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans | 期刊论文 | Jie Gao;Xin Tian;Jun Zhou;Minzhu Cui;Haifeng Zhang;Na Gao;Qiang Wen;Hailing Qiao |
| 14 | Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes | 期刊论文 | Na Gao;Xin Tian;Yan Fang;Jun Zhou;Haifeng Zhang;Qiang Wen;Linjing Jia;Jie Gao;Bao Sun;Jinyao Wei;Yunfei Zhang;Minzhu Cui;Hailing Qiao |
| 15 | Higher CYP2E1 activity correlates with hepatocarcinogenesis induced by diethylnitrosamine | 期刊论文 | Gao Jie;Wang Zhao;Wang Gao-Ju;Zhang Hong-Xin;Gao Na;Wang Jie;Wang Cai-E;Chang Zhao;Fang Yan;Zhang Yun-Fei;Zhou Jun;Jin Han;Qiao Hai-Ling |
| 16 | Intra-individual Variation and Correlation of Cytochrome P450 Activities in Human Liver Microsomes | 期刊论文 | Fang Yan;Gao Jie;Wang Tong;Tian Xin;Gao Na;Zhou Jun;Zhang Hai-Feng;Wen Qiang;Jin Han;Xing Yu-Rong;Qiao Hai-Ling |
| 17 | Higher activity of alcohol dehydrogenase is correlated with hepatic fibrogenesis | 期刊论文 | Gao Na;Li Jing;Li Ming-Rui;Wang Zhao;Wang Gao-Ju;Gao Jie;Qiao Hai-Ling |
| 18 | Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats | 期刊论文 | Wang Gao-Ju;Xiao Kang;Gao Jie;Jiang Shan;Wang Shang;Weng Shi-Jia;Xu Chen;Wang Tong;Qiao Hai-Ling |
| 19 | From hepatofibrosis to hepatocarcinogenesis: higher cytochrome P450 2E1 activity is a potential risk factor | 期刊论文 | Gao Jie;Wang Zhao;Wang Gao-Ju;Gao Na;Li Jing;Zhang Yun-Fei;Zhou Jun;Zhang Hong-Xin;Wen Qiang;Jin Han;Qiao Hai-Ling |
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