基于“合成生物学-纳米光遗传学”肠菌移植凝胶系统的帕金森症肠脑轴调控研究
31971300
2019
C1007.纳米生物学
王汉杰
面上项目
教授
天津大学
57万元
稀土上转换光遗传学;肠脑轴调控;响应性载体;肠道菌群;多功能载体
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticles | 期刊论文 | Wang Hanjie;Zhang Chaonan;Zhang Yingying;Tian Ran;Cheng Guohui;Pan Huizhuo;Cui Meihui;Chang Jin |
| 2 | Sonogenetic nanosystem activated mechanosensitive ion channel to induce cell apoptosis for cancer immunotherapy | 期刊论文 | He Tiandi;Wang Hanjie;Wang Tiange;Pang Gaoju;Zhang Yingying;Zhang Chaonan;Yu Peng;Chang Jin |
| 3 | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy | 期刊论文 | Tian Ran;Wang Zhaosong;Niu Ruifang;Wang Hanjie;Guan Weijiang;Chang Jin |
| 4 | Upconversion Optogenetic Engineered Bacteria System for Time-Resolved Imaging Diagnosis and Light-Controlled Cancer Therapy | 期刊论文 | Yingying Zhang;Xin Xue;Mingxi Fang;Gaoju Pang;Yujuan Xing;Xinyu Zhang;Lianyue Li;Qu Chen;Yuxin Wang;Jin Chang;Peiqi Zhao;Hanjie Wang |
| 5 | 黄家驷生物医学工程科技进步奖 | 奖励 | 常津;鞠煌先;李彤;刘萍;宫晓群;严枫;王汉杰;武晓丽 |
| 6 | Optotheranostic Nanosystem with Phone Visual Diagnosis and Optogenetic Microbial Therapy for Ulcerative Colitis At-Home Care | 期刊论文 | Cui Meihui;Pang Gaoju;Zhang Tao;Sun Tao;Zhang Lili;Kang Ruru;Xue Xin;Pan Huizhuo;Yang Chun;Zhang Xinyu;Chang Jin;Liu Jing;Zhang Shufang;Wang Hanjie |
| 7 | Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem | 期刊论文 | Hao Yafeng;Du Taofeng;Pang Gaoju;Li Jiahua;Pan Huizhuo;Zhang Yingying;Wang Lizhen;Chang Jin;Zhou En-min;Wang Hanjie |
| 8 | CRISPR-dcas9 Optogenetic Nanosystem for the Blue Light-Mediated Treatment of Neovascular Lesions | 期刊论文 | Li Jiahua;Hao Yafeng;Pan Huizhuo;Zhang Yingying;Cheng Guohui;Liu Baona;Chang Jin;Wang Hanjie |
| 9 | Hydrogel microcapsules containing engineered bacteria for sustained production and release of protein drugs | 期刊论文 | Chunli Han;Xinyu Zhang;Gaoju Pang;Yingying Zhang;Huizhuo Pan;Lianyue Li;Meihui Cui;Baona Liu;Ruru Kang;Xin Xue;Tao Sun;Jing Liu;Jin Chang;Peiqi Zhao;Hanjie Wang |
| 10 | 非诊断目的基于靶标等温循环扩增及核酸试纸条技术检测miRNA-21的方法及试剂盒 | 专利 | 常津;陈明慧;宫晓群;王汉杰 |
| 11 | Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy | 期刊论文 | Pan Huizhuo;Li Lianyue;Pang Gaoju;Han Chunli;Liu Baona;Zhang Yingying;Shen Yue;Sun Tao;Liu Jing;Chang Jin;Wang Hanjie |
| 12 | Rapid, simultaneous detection of mycotoxins with smartphone recognition-based immune microspheres | 期刊论文 | Zhang Lili;Zhang Ziyu;Tian Yu;Cui Meihui;Huang Beibei;Luo Tao;Zhang Shufang;Wang Hanjie |
| 13 | An injectable hydrogel co-loading with cyanobacteria and upconversion nanoparticles for enhanced photodynamic tumor therapy | 期刊论文 | Zhang Xinyu;Zhang Yingying;Zhang Chaonan;Yang Chun;Tian Ran;Sun Tao;Zhang Weiwen;Chang Jin;Wang Hanjie |
| 14 | A Logic AND-Gated Sonogene Nanosystem for Precisely Regulating the Apoptosis of Tumor Cells | 期刊论文 | Wang Tiange;Wang Hanjie;Pang Gaoju;He Tiandi;Cheng Guohui;Zhang Yingying;Chang Jin |
| 15 | Light-Sensitive Lactococcus lactis for Microbe−Gut−Brain Axis Regulating via Upconversion Optogenetic Micro-Nano System | 期刊论文 | Huizhuo Pan;Tao Sun;Meihui Cui;Ning Ma;Chun Yang;Jing Liu;Gaoju Pang;Baona Liu;Lianyue Li;Xinyu Zhang;Weiwen Zhang;Jin Chang;Hanjie Wang |
| 16 | NIR light-responsive bacteria with live bio-glue coatings for precise colonization in the gut | 期刊论文 | Meihui Cui;Tao Sun;Shubin Li;Huizhuo Pan;Jing Liu;Xinyu Zhang;Lianyue Li;Shanshan Li;Chunyang Wei;Chengzhuang Yu;Chun Yang;Ning Ma;Binglin Ma;Shenjunjie Lu;Jin Chang;Weiwen Zhang;Hanjie Wang |
| 17 | A red light-controlled probiotic bio-system for in-situ gut-brain axis regulation | 期刊论文 | Xinyu Zhang;Gaoju Pang;Tao Sun;Xinyu Liu;Huizhuo Pan;Yingying Zhang;Jing Liu;Jin Chang;Hanjie Wang;Duo Liu |
| 18 | Upconversion optogenetic micro-nanosystem optically controls the secretion of light-responsive bacteria for systemic immunity regulation | 期刊论文 | Yang Chun;Cui Meihui;Zhang Yingying;Pan Huizhuo;Liu Jing;Wang Shixing;Ma Ning;Chang Jin;Sun Tao;Wang Hanjie |
| 19 | Smartphone bioelectronic drug with visual colorimetric sensor and bulknanoencapsulation optogenetic bacteria for chronic kidney disease theragnostics | 期刊论文 | Meihui Cui;Wei Ling;Lili Zhang;Yayang Li;Jing Liu;Tao Sun;Binglin Ma;Shenjunjie Lu;Huizhuo Pan;Gaoju Pang;Yingying Zhang;Shufang Zhang;Xian Huang;Peiqi Zhao;Duo Liu;Hanjie Wang |
| 20 | A programmable oral bacterial hydrogel for controllable production and release of nanovaccine for tumor immunotherapy | 期刊论文 | Yingying Zhang;Ruru Kang;Xinyu Zhang;Gaoju Pang;Lianyue Li;Chunli Han;Baona Liu;Xin Xue;Jing Liu;Tao Sun;Tao Wang;Peiyuan Liu;Hanjie Wang |
| 21 | Sodium Alginate Hydrogel-Mediated Cancer Immunotherapy for Postoperative In Situ Recurrence and Metastasis | 期刊论文 | Zhang Yingying;Wang Tiange;Zhuang Yinping;He Tiandi;Wu Xiaoli;Su Lin;Kang Jun;Chang Jin;Wang Hanjie |
| 22 | A micro-nano optogenetic system based on probiotics for in situ host metabolism regulation | 期刊论文 | Xinyu Zhang;Ning Ma;Wei Ling;Gaoju Pang;Tao Sun;Jing Liu;Huizhuo Pan;Meihui Cui;Chunli Han;Chun Yang;Jin Chang;Xian Huang;Hanjie Wang |
| 23 | Hydrogel-Encapsulated Engineered Microbial Consortium as a Photoautotrophic “Living Material” for Promoting Skin Wound Healing | 期刊论文 | Lianyue Li;Chun Yang;Binglin Ma;Shenjunjie Lu;Jing Liu;Yiyang Pan;Xuyan Wang;Yiliang Zhang;Hanjie Wang;Tao Sun;Duo Liu |
| 24 | Multifunctional nano-photosensitizer: A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility | 期刊论文 | Cheng Guohui;Wang Hanjie;Zhang Chaonan;Hao Yafeng;Wang Tiange;Zhang Yingying;Tian Yu;Chang Jin |
| 25 | 2022年度中国颗粒学会青年颗粒学奖 | 奖励 | 王汉杰 |
| 26 | Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence | 期刊论文 | Zhang Yingying;Wang Tiange;Tian Yu;Zhang Chaonan;Ge Kun;Zhang Jinchao;Chang Jin;Wang Hanjie |
| 27 | "Magnetism-Optogenetic" System for Wireless and Highly Sensitive Neuromodulation | 期刊论文 | Tian Yu;Zhang Yingying;Zhang Xinyu;Pan Huizhuo;Zhang Lili;Liu Shuang;Chen Yulan;Su Lin;Zhao Peiqi;Chang Jin;Wang Hanjie |
| 28 | Precise Thermal Regulation of Engineered Bacteria Secretion for Breast Cancer Treatment In Vivo | 期刊论文 | Lianyue Li;Huizhuo Pan;Gaoju Pang;Haoyu Lang;Yue Shen;Tao Sun;Yingying Zhang;Jing Liu;Jin Chang;Jun Kang;Hao Zheng;Hanjie Wang |
| 29 | Remote Regulation of Optogenetic Proteins by a Magneto-Luminescence Microdevice | 期刊论文 | Zhang Yingying;Zhang Xin;Wang Hanjie;Tian Yu;Pan Huizhuo;Zhang Lili;Wang Feng;Chang Jin |
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