mTORC1/mTORC2信号通路在增龄性骨丢失中的作用及其调节机制
U1301222
2013
H0604.骨、关节、软组织损伤与修复
白晓春
联合基金项目
教授
南方医科大学
260万元
mTORC2;mTORC1;老年性骨质疏松;增龄性骨丢失;衰老
2014-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin. | 期刊论文 | Zou Zhipeng;Chen Juan;Yang Jun;Bai Xiaochun |
| 2 | Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation. | 期刊论文 | Miao Liu;Ling Zhou;Baiyu Zhang;Minhong He;Xiaoying Dong;Xiaojun Lin;Chunhong Jia;Xiaochun Bai;Yifan Dai;Yongchun Su;Zhipeng Zou;Hang Zheng |
| 3 | Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. | 期刊论文 | Huang Bin;Wang Wenhao;Li Qingchu;Wang Zhenyu;Yan Bo;Zhang Zhongmin;Wang Liang;Huang Minjun;Jia Chunhong;Lu Jiansen;Liu Sichi;Chen Hongdong;Li Mangmang;Cai Daozhang;Jiang Yu;Jin Dadi;Bai Xiaochun |
| 4 | Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2 | 期刊论文 | Wang Hua;Zhang Haiyan;Sun Qiuyi;Wang Yun;Yang Jun;Yang Jincheng;Zhang Tao;Luo Shenqiu;Wang Liping;Jiang Yu;Zeng Chun;Cai Daozhang;Bai Xiaochun |
| 5 | mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. | 期刊论文 | Huang Bin;Wang Yongkui;Wang Wenhao;Chen Juan;Lai Pinglin;Liu Zhongyu;Yan Bo;Xu Song;Zhang Zhongmin;Zeng Chun;Rong Limin;Liu Bin;Cai Daozhang;Jin Dadi;Bai Xiaochun |
| 6 | GDF11 Inhibits Bone Formation by Activating Smad2/3 in Bone Marrow Mesenchymal Stem Cells | 期刊论文 | Lu Qiong;Tu Man-Li;Li Chang-Jun;Zhang Li;Jiang Tie-Jian;Liu Tang;Luo Xiang-Hang |
| 7 | Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes. | 期刊论文 | Zhang Yue;Xu Song;Liang Kang-Yan;Li Kai;Zou Zhi-Peng;Yang Cui-Lan;Tan Kang;Cao Xiong;Jiang Yu;Gao Tian-Ming;Bai Xiao-Chun |
| 8 | Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis. | 期刊论文 | Dong Heling;Chen Zhenguo;Wang Caixia;Xiong Zhi;Zhao Wanlu;Jia Chunhong;Lin Jun;Lin Yan;Yuan Weiping;Zhao Allan Z;Bai Xiaochun |
| 9 | Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of beta-Catenin and RANKL/OPG. | 期刊论文 | Xu Song;Zhang Yue;Liu Bin;Li Kai;Huang Bin;Yan Bo;Zhang Zhongmin;Liang Kangyan;Jia Chunhong;Lin Jun;Zeng Chun;Cai Daozhang;Jin Dadi;Jiang Yu;Bai Xiaochun |
| 10 | MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity | 期刊论文 | Yang Mi;Li Chang-Jun;Sun Xi;Guo Qi;Xiao Ye;Su Tian;Tu Man-Li;Peng Hui;Lu Qiong;Liu Qing;He Hong-Bo;Jiang Tie-Jian;Lei Min-Xiang;Wan Mei;Cao Xu;Luo Xiang-Hang |
| 11 | mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis | 期刊论文 | Zhang H.;Wang H.;Zeng C.;Yan B.;Ouyang J.;Liu X.;Sun Q.;Zhao C.;Fang H.;Pan J.;Xie D.;Yang J.;Zhang T.;Bai X.;Cai D. |
| 12 | Osteoblasts support megakaryopoiesis through production of interleukin-9 | 期刊论文 | Xiao Min;Wang Yongkui;Tao Chen;Wang Zhenyu;Yang Jun;Chen Zhenguo;Zou Zhipeng;Li Mangmang;Liu Anling;Jia Chunhong;Huang Bin;Yan Bo;Lai Pinglin;Ding Changhai;Cai Daozhang;Xiao Guozhi;Jiang Yu;Bai Xiaochun |
| 13 | mTORC1 Inhibits NF-kappa B/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice | 期刊论文 | Zhang Yue;Xu Song;Li Kai;Tan Kang;Liang Kangyan;Wang Jian;Shen Junhui;Zou Wenchong;Hu Le;Cai Daozhang;Ding Changhai;Li Mangmang;Xiao Guozhi;Liu Bin;Liu Anling;Bai Xiaochun |
| 14 | mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. | 期刊论文 | Zou Z;Chen J;Liu A;Zhou X;Song Q;Jia C;Chen Z;Lin J;Yang C;Li M;Jiang Y;Bai X |
| 15 | mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. | 期刊论文 | Yan Bo;Zhang Zhongmin;Jin Dadi;Cai Chen;Jia Chunhong;Liu Wen;Wang Ting;Li Shengfa;Zhang Haiyan;Huang Bin;Lai Pinglin;Wang Hua;Liu Anling;Zeng Chun;Cai Daozhang;Jiang Yu;Bai Xiaochun |
| 16 | Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. | 期刊论文 | Chen Zhenguo;Kang Xiangjin;Wang Liping;Dong Heling;Wang Caixia;Xiong Zhi;Zhao Wanlu;Jia Chunhong;Lin Jun;Zhang Wen;Yuan Weiping;Zhong Mei;Du Hongzi;Bai Xiaochun |
| 17 | Loss of Rictor with aging in osteoblasts promotes age-related bone loss | 期刊论文 | Lai Pinling;Song Qiancheng;Yang Cheng;Li Zhen;Liu Sichi;Liu Bin;Li Mangmang;Deng Hongwen;Cai Daozhang;Jin Dadi;Liu Anling;Bai Xiaochun |
| 18 | mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. | 期刊论文 | Yang Jun;Zhou Xuan;Fan Xiaorong;Xiao Min;Yang Dinghua;Liang Bo;Dai Meng;Shan Lanlan;Lu Jingbo;Lin Zhiqi;Liu Rong;Liu Jun;Wang Liping;Zhong Mei;Jiang Yu;Bai Xiaochun |
| 19 | Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice | 期刊论文 | Yang Cheng;Chen Yuhui;Li Zhen;Cao He;Chen Keming;Lai Pinglin;Yan Bo;Huang Bin;Tang Jiajun;Fan Shicai;Cai Daozhang;Jin Dadi;Bai Xiaochun;Zhou Rongping |
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