核受体-UGT代谢网络与结肠炎癌症转化的互动调控分子机制

91029746
2010
H3510.药物代谢与药物动力学
郝海平
重大研究计划
教授
中国药科大学
55万元
结肠癌;内源性致癌物;结肠炎;UGT;核受体
2011-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver 期刊论文 H.|L.|Chu|X.|Wang|H.|Xie|H.|Guo|
2 Cytochrome P450 Dysregulations in Thioacetamide-Induced Liver Cirrhosis in Rats and the Counteracting Effects of Hepatoprotective Agents 期刊论文 Xie, Yuan|Wang, Guangji|Wang, Hong|Yao, Xiling|Jiang, Shan|Kang, An|Zhou, Fang|Hao, Haiping|
3 Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients 期刊论文 Chu, Xiao-Man|Zhang, Li-Fang|Wang, Guang-Ji|Zhang, Shen-Ning|Zhou, Jia-Hui|Hao, Hai-Ping|
4 Thioacetamide intoxication triggers transcriptional up-regulation but enzyme inactivation of UDP-glucuronosyltransferases 期刊论文 Hao, Haiping|Zhang, Lifang|Jiang, Shan|Sun, Shiqing|Gong, Ping|Xie, Yuan|Zhou, Xueyan|Wang, Guangji|
5 中药药代动力学关键技术体系的创新及应用 奖励 王广基|郝海平|梁艳|孙建国|阿基业|周芳|郝琨|张经纬|
6 Metabolic profile, enzyme kinetics, and reaction phenotyping of β-lapachone metabolism in human liver and intestine in vitro 期刊论文 Chen,Xuefang|Liu,Fang|Yan,Tingting|Zhou,Xueyan|Wu,Liang|Liao,Ke|Wang,Guangji|Hao,Haiping|
7 Disturbance of Hepatic and Intestinal UDP-glucuronosyltransferase in Rats with Trinitrobenzene Sulfonic Acid-induced Colitis 期刊论文 Zhou, Xueyan|Xie, Yang|Qi, Qu|Cheng, Xuefang|Liu, Fang|Liao, Ke|Wang, Guangji|Hao, Haiping|
8 Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry 期刊论文 Zheng, Xiao|Kang, An|Dai, Chen|Liang, Yang.|Xie, Tong|Xie, Lin|Peng, Ying.|Wang, Guangji|Hao, Haiping|
9 Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes 期刊论文 H.|H.|Sun|S.|Cheng|X.|Yan|T.|Zheng|
10 UDP-Glucuronosyltransferase 1A Compromises Intracellular Accumulation and Anti-Cancer Effect of Tanshinone IIA in Human Colon Cancer Cells 期刊论文 M.|H.|Wang|Q.|Liu|F.|Cheng|X.|Wu|
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