非可控性炎症恶性转化过程中关键分子事件的研究

91029744
2010
H3505.抗肿瘤药物药理
郭青龙
重大研究计划
教授
中国药科大学
70万元
Nrf2;炎癌转化;NFκB
2011-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. 期刊论文 郭青龙|
2 Oroxylin a inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. 期刊论文 郭青龙|
3 Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells 期刊论文 郭青龙|
4 ~Drug Resistance Associates With Activation of Nrf2 in MCF-7/DOX Cells, and Wogonin Reverses it by Down-Regulating Nrf2-Mediated Cellular Defense Response. 期刊论文 郭青龙|
5 Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest 期刊论文 Yao J|Li Z|Wu G|Guo Q|
6 The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells. 期刊论文 Zhang F|Li ZY|You QD|Guo GL|
7 HQS-3, a newly synthesized flavonoid, possesses potent anti-tumor effect in vivo and in vitro 期刊论文 郭青龙|
8 GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin 期刊论文 郭青龙|
9 Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. 期刊论文 郭青龙|
10 Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. 期刊论文 郭青龙|
11 LYG-202 augments tumor necrosis factor-α-induced apoptosis via attenuating CK2-dependent nuclear factor-κB pathway in HepG2 cells. 期刊论文 郭青龙|
12 HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. 期刊论文 郭青龙|
13 Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT 期刊论文 郭青龙|
14 Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells 期刊论文 郭青龙|
15 Oroxylin A reverses CAM-DR of HepG2 cells by suppressing Integrinβ1 and its related pathway. 期刊论文 郭青龙|
16 Oroxylin A prevents inflammation-related tumor through the down-regulation of inflammatory gene expression by inhibiting NF-κB activation. 期刊论文 Zhu B|You QD|Yan T|Guo QL|
17 Activation of the unfolded protein response contributed to the selective cytotoxicity of Oroxylin A in human hepatocellular carcinoma HepG2 cells 期刊论文 郭青龙|
18 Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II 期刊论文 郭青龙|
19 LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells. 期刊论文 郭青龙|
20 Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors 期刊论文 郭青龙|
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