【90713037】五环三萜对糖原代谢调节作用的分子机制及靶标蛋白研究国家自然基金项目

五环三萜对糖原代谢调节作用的分子机制及靶标蛋白研究

项目批准号： 90713037

批准年份： 2007

学科分类： H3402.天然药物化学

项目负责人：孙宏斌

资助类别：重大研究计划

负责人职称：教授

依托单位：中国药科大学

资助金额： 50万元

关键词：糖原代谢;糖尿病;探针;信号转导;五环三萜

起止时间： 2008-01-01到2010-12-31

中英文摘要
结题摘要
结题报告
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序号	标题	类型	作者
1	Synthesis of 3-Deoxypentacyclic Triterpene Derivatives as Inhibitors of Glycogen Phosphorylase	期刊论文	Lu, Qian\|Zhang, Pu\|Hao, Jia\|Sheng, Huaming\|Sun, Hongbin\|Liu, Jun\|Zhang, Luyong\|
2	Synthesis of nucleoside conjugates as potential inhibitors of glycogen phosphorylase	期刊论文	孙宏斌\|
3	Efficient synthesis of morolic acid and related triterpenes starting from betulin	期刊论文	Hao, Jia\|Zhang, Pu\|Zhang, Luyong\|Sun, Hongbin\|Liu, Jun\|
4	大鼠肝脏缺血-再灌注损伤时齐墩果酸对氧自由基的影响	期刊论文	孙宏斌\|许仄平\|张杰\|姚爱华\|钱燕宁\|
5	Synthesis of Oleanolic Acid Dimers as Inhibitors of Glycogen Phosphorylase	期刊论文	Sun, Hongbin\|Cheng, Keguang\|Liu, Jun\|Xie, Juan\|
6	Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase	期刊论文	Cheng, Keguang\|Liu, Jun\|Docsa, Tibor\|Toth, Marietta\|Czifrak, Katalin\|Somsak, Laszlo\|Sun, Hongbin\|Konya, Balint\|Bokor, Eva\|Gergely, Pal\|
7	Efficient Access to 2-Isobetulinic Acid, 2-Isooleanolic Acid and 2-Isoursolic Acid.	期刊论文	孙宏斌\|
8	Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats	期刊论文	Shang, Jing\|Lu, Qian\|He, Ting\|Zhang, Luyong\|Liu, Jun\|Sun, Hongbin\|
9	齐墩果酸预处理对大鼠肝脏缺血再灌注时糖原含量的影响	期刊论文	陆森\|许仄平\|孙宏斌\|张杰\|钱燕宁\|
10	Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4-Epi-hederagonic Acid as Glycogen Phosphorylase Inhibitors.	期刊论文	孙宏斌\|
11	Maslinic acid reduces blood glucose and body weight in KK-Ay mice.	期刊论文	孙宏斌\|
12	Efficient access to isomeric 2,3-dihydroxy lupanes: first synthesis of alphitolic acid	期刊论文	Hao, Jia\|Zhang, Xueli\|Zhang, Luyong\|Liu, Jun\|Zhang, Pu\|Sun, Hongbin\|
13	杂环并五环三萜化合物的合成及糖原磷酸化酶抑制活性	期刊论文	张迎霞\|孙宏斌\|张陆勇\|倪沛洲\|柳军\|温小安\|
14	Practical Synthesis of Bredemolic Acid, a Natural Inhibitor of Glycogen Phosphorylase	期刊论文	Cheng, Keguang\|Xie, Juan\|Liu, Jun\|Zhang, Pu\|Sun, Hongbin\|
15	Synthesis and biological evaluation of 3-deoxy-pentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase	期刊论文	孙宏斌\|
16	Synthesis and Biological Evaluation of Asiatic acid Derivatives as Inhibitors of Glycogen Phosphorylase.	期刊论文	孙宏斌\|
17	Efficient synthesis of morolic acid and related triterpenes starting from betulin.	期刊论文	孙宏斌\|
18	Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships and X-ray Crystallographic Studies.	期刊论文	孙宏斌\|
19	Synthesis and Biological Evaluation of S ubstituted phenylpyrazole [4,5-b]oleanane Derivatives as Inhibitors of Glycogen Phosphorylase .	期刊论文	孙宏斌\|
20	Efficient Access to Isomeric 2, 3-Dihydroxy Lupanes: First Synthesis of Alphitolic Acid	期刊论文	孙宏斌\|
21	Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.	期刊论文	孙宏斌\|
22	Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase	期刊论文	Liu, Jun\|Sun, Hongbin\|Liu, Xiaofeng\|Xie, Juan\|Li, Honglin\|Cheng, Keguang\|
23	Pentacyclic Triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases.	期刊论文	孙宏斌\|
24	Synthesis and Biological Evaluation of Novel Pyrazolo[4,3-b]oleanane Derivatives as Inhibitors of Glycogen Phosphorylase.	期刊论文	孙宏斌\|
25	Practical Synthesis of Bredemolic Acid, a Natural Inhibitor of Glycogen Phosphorylase.	期刊论文	孙宏斌\|
26	Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase	期刊论文	Xie, Juan\|Sun, Hongbin\|Wang, Chao\|Cheng, Keguang\|Liu, Jun\|
27	Effects of O leanolic A cid and M aslinic A cid on H yperlipidemia.	期刊论文	孙宏斌\|
28	Synthesis and biological evaluation of C-28 oleanolic acid derivatives as inhibitors of glycogen phosphorylase	期刊论文	孙宏斌\|
29	Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase	期刊论文	孙宏斌\|
30	Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase.	期刊论文	孙宏斌\|
31	Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid	期刊论文	Zhang, Pu\|Sun, Hongbin\|Wen, Xiaoan\|Hao, Jia\|
32	Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies	期刊论文	Liu, Jun\|Wen, Xiaoan\|Ni, Peizhou\|Zhang, Pu\|Hao, Jia\|Hayes, Joseph M.\|Sun, Hongbin\|Cheng, Keguang\|Gimisis, Thanasis\|Leonidas, Demetres D.\|Zographos, Spyros E.\|Zhang, Luyong\|Zhang, Liying\|Alexacou, Kyra-Melinda\|Oikonomakos, Nikos G.\|
33	Synthesis and Biological Evaluation of Asiatic Acid Derivatives as Inhibitors of Glycogen Phosphorylases	期刊论文	Liu, Jun\|Zhang, Luyong\|Hua, Weiyi\|Zhang, Liying\|Chen, Jun\|Gong, Yanchun\|Sun, Hongbin\|

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