酸浆属清热解毒中药抗肿瘤睡茄内酯的发现及其作用靶点研究

81872983
2018
H3203.中药药效物质
罗建光
面上项目
教授
中国药科大学
57万元
作用靶点;酸浆属;抗肿瘤作用;睡茄内酯;小分子亲和探针
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer 期刊论文 Chen Chen;Lijie Gong;Xiaoqin Liu;Tianyu Zhu;Wuxi Zhou;Lingyi Kong;Jianguang Luo
2 Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect 期刊论文 Dongrong Zhu;Shang Li;Chen Chen;Sibei Wang;Jiangmin Zhu;Lingyi Kong;Jianguang Luo
3 Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling 期刊论文 Dejuan Xiang;Jie Zou;Xiaoyun Zhu;Xinling Chen;Jianguang Luo;Lingyi Kong;Hao Zhang
4 Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling 期刊论文 Chen Chen;Tianyu Zhu;Xiao-Qin Liu;Dongrong Zhu;Yi Zhang;Sifang Wu;Chao Han;Jianguang Luo;Lingyi Kong
5 Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A 期刊论文 Dongrong Zhu;Chen Chen;Xiao-Qin Liu;Sibei Wang;Jiangmin Zhu;Hao Zhang;Lingyi Kong;Jianguang Luo
6 Cellular target identification of Withangulatin A using fluorescent analogues and subsequent chemical proteomics 期刊论文 Tianyu Zhu;Chen Chen;Sisi Wang;Yi Zhang;Dongrong Zhu;Lingnan Li;Jianguang Luo;Lingyi Kong
7 Identification of Tubocapsanolide A as a novel NLRP3 inhibitor for potential treatment of colitis 期刊论文 Chen Chen;Xiaoqin Liu;Lijie Gong;Tianyu Zhu;Wuxi Zhou;Lingyi Kong;Jianguang Luo
8 Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents 期刊论文 Zhou Wu-Xi;Chen Chen;Liu Xiao-Qin;Li Ying;Kong Ling-Yi;Luo Jian-Guang
9 Physalin B在制备预防与治疗非酒精性脂肪性肝病药物或保健品中应用 专利 孔令义;罗建光;张浩;祝小云;陈馨霖;张美卉
10 苦蘵中睡茄内酯提取物在制备预防或治疗非酒精性脂肪性肝病的药物中应用 专利 罗建光;张浩;陈馨霖;项德娟;张美卉
11 Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer 期刊论文 Wu-Xi Zhou;Chen Chen;Xiao-Qin Liu;Ying Li;Yao-Lan Lin;Xiu-Tao Wu;Ling-Yi Kong;Jian-Guang Luo
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