无定形药物固体分散体的分子运动性和结晶动力学机制研究

81872813
2018
H3408.药剂学
蔡挺
面上项目
教授
中国药科大学
57万元
物理稳定性;无定形药物;分子运动性;固体分散体;结晶速率
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice 期刊论文 Shamuha Bahetibieke;Sakib M. Moinuddin;Asiya Baiyisaiti;Xiaoang Liu;Jie Zhang;Guomin Liu;Qin Shi;Ankang Peng;Jun Tao;Chang Di;Ting Cai;Rong Qi
2 Crack- and Bubble-Induced Fast Crystal Growth of Amorphous Griseofulvin 期刊论文 Shi Qin;Tao Jun;Zhang Jie;Su Yuan;Cai Ting
3 Simultaneously Improving the Physicochemical Properties, Dissolution Performance, and Bioavailability of Apigenin and Daidzein by Co-Crystallization With Theophylline 期刊论文 Huang Shan;Xue Qian;Xu Jia;Ruan Sida;Cai Ting
4 Modulation of Solid-State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid 期刊论文 Minshan Guo;Xiaojie Sun;Shaozheng Zhang;Ting Cai
5 Enhanced Physical Stability and Synchronized Release of Febuxostat and Indomethacin in Coamorphous Solids 期刊论文 Sakib M.Moinuddin;Qin Shi;Jun Tao;Minshan Guo;Jie Zhang;Qian Xue;Sida Ruan;Ting Cai
6 Fenton-reaction-triggered metabolism of acetaminophen for enhanced cancer therapy 期刊论文 Fanwen Sun;Yayun Peng;Yanping Li;Menghan Xu;Ting Cai
7 无定形固体分散体的溶出与吸收研究进展 期刊论文 吴昊旻;张杰;骆敏倩;蔡挺
8 Activatable Core-Shell Metallofullerene: An Efficient Nanoplatform for Bimodal Sensing of Glutathione 期刊论文 Yayun Peng;Chao Ye;Runqi Yan;Yuzhu Lei;Deju Ye;Hao Hong;Ting Cai
9 Enhanced Crystal Nucleation in Glass-Forming Liquids by Tensile Fracture in the Glassy State 期刊论文 Su Yuan;Yu Lian;Cai Ting
10 Crystallization kinetics and molecular dynamics of binary coamorphous systems of nimesulide and profen analogs 期刊论文 Jie Zhang;Qin Shi;Tengfei Qu;Dongshan Zhou;Ting Cai
11 Solvent-Induced, Highly Unusual, Triangular-Shaped Organic Polar Crystal 期刊论文 Xu Jia;Huang Shan;Cai Ting
12 Polymorphism of Purpurin and Low-level Detection of the Noncentrosymmetric form by Second Harmonic Generation Microscopy 期刊论文 Jia Xu;An Chen;Ting Cai
13 加巴喷丁与2,6-吡啶二羧酸的盐及其制备方法与应用 专利 蔡挺;郭敏珊;孙晓杰
14 Melt Crystallization of Indomethacin Polymorphs in the Presence of Poly(ethylene oxide): Selective Enrichment of the Polymer at the Crystal-Liquid Interface 期刊论文 Zhang Jie;Shi Qin;Guo Minshan;Liu Zhengyu;Cai Ting
15 Amorphous phase-mediated crystallization of calcium pyrophosphate tetrahydrate: the role of alkaline earth metal ions 期刊论文 Shiwen Cui;Yuan Su;Ting Cai
16 Effect of polymeric excipients on nucleation and crystal growth kinetics of amorphous fluconazole 期刊论文 Jie Zhang;Zhengyu Liu;Haomin Wu;Ting Cai
17 Facile Tuning of the Photoluminescence and Dissolution Properties of Phloretin through Cocrystallization 期刊论文 Shan Huang;Jia Xu;Yayun Peng;Minshan Guo;Ting Cai
18 Transforming Passive into Active: Multimodal Pheophytin-Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer. 期刊论文 Yayun Peng;Yiyang Cong;Yuzhu Lei;Fanwen Sun;Menghan Xu;Jingzi Zhang;Lei Fang;Hao Hong;Ting Cai
19 Pharmaceutical cocrystals: a review of preparations, physicochemical properties and applications 期刊论文 Minshan Guo;Xiaojie Sun;Jiahui Chen;Ting Cai
20 Advances in coamorphous drug delivery systems 期刊论文 Qin Shi;Sakib M Moinuddin;Ting Cai
21 Structure–thermomechanical property correlation in polymorphic molecular crystals probed by the nanoindentation technique 期刊论文 Yuan Su;Surojit Bhunia;Shuyuan Xu;An Chen;C. Malla Reddy;Ting Cai
22 Impact of Polymer Enrichment at the Crystal-Liquid Interface on Crystallization Kinetics of Amorphous Solid Dispersions 期刊论文 Zhang Jie;Shi Qin;Tao Jun;Peng Yayun;Cai Ting
23 Glutathione responsive cubic gel particles cyclodextrin metal-organic frameworks for intracellular drug delivery 期刊论文 Xue Qian;Ye Chao;Zhang Mengmeng;Hu Xiongwei;Cai Ting
24 Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics 期刊论文 Jiahui Chen;Minshan Guo;Runhui Fan;Yayun Peng;Ting Cai
25 一种防治蒽环类抗生素心脏毒性的药物组合物及其应用 专利 蔡挺;蔡宝昌;史长灿
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