具有ABC转运蛋白抑制功能的新型EGFR抑制剂的分子构建及作用机制研究

81872733
2018
H3401.合成药物化学
黄文龙
面上项目
教授
中国药科大学
57万元
ABC转运蛋白;EGFR抑制剂;肿瘤多药耐药
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo c thiazolo 4,5-e azepin-2-one derivatives as potential BRD4 inhibitors 期刊论文 Qifei Li;Jieming Li;Yan Cai;Yuxing Zou;Bin Chen;Feng Zou;Jiaxian Mo;Ting Han;Weiwei Guo;Wenlong Huang;Qianqian Qiu;Hai Qian
2 Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy 期刊论文 Wei Shi;Qianqian Qiu;Ziying Feng;Zhenzhen Tong;Weiwei Guo;Feng Zou;Na Yue;Wenlong Huang;Hai Qian
3 Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-o xo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance 期刊论文 Qianqian Qiu;Jiaqi Zhou;Wei Shi;Mutta Kairuki;Wenlong Huang;Hai Qian
4 Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents 期刊论文 Qianqian Qiu;Wei Shi;Shiyuan Zhao;Yan Zhu;Zhengquan Ding;Shaoyang Zhou;Mutta Kairuki;Wenlong Huang;Hai Qian
5 Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance 期刊论文 Qianqian Qiu;Jilan Zhu;Qiutong Chen;Ziqian Jiang;Jiting Xu;Xueting Jiang;Wenlong Huang;Zhongquan Liu;Jing Ye;Xiaojuan Xu
6 Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells, 期刊论文 Mutta Kairuki;Qianqian Qiu;Miaobo Pan;Qifei Li;Jiaqi Zhou;Hesham Ghaleb;Wenlong Huang;Hai Qian;Cheng Jiang
7 Histology and antitumor activity study of PTX-loaded micelle, a fluorescent drug delivery system prepared by PEG-TPP 期刊论文 Huilan Li;Jieming Li;Xinyi He;Bo Zhang;Chunxia Liu;Qifei Li;Ying Zhu;Wenlong Huang;Wei Zhang;Hai Qian;Liang Ge
8 Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α 期刊论文 Yuxuan Dai;Na Yue;Junni Gong;Chunxia Liu;Qifei Li;Jiaqi Zhou;Wenlong Huang;Hai Qian
9 Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P‑gp- and BCRP-Mediated Multidrug Resistance 期刊论文 Qianqian Qiu;Feng Zou;Huilan Li;Wei Shi;Daoguang Zhou;Ping Zhang;Teng Li;Ziyu Yin;Zilong Cai;Yuxuan Jiang;Wenlong Huang;Hai Qian
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