基于“肺-肠”微生态-代谢-免疫轴的川贝母活性物质组治疗哮喘的作用机制研究

81773872
2017
H3203.中药药效物质
辛贵忠
面上项目
副教授
中国药科大学
57万元
活性物质组;“肺-肠”微生态-代谢-免疫轴;代谢组学;哮喘;川贝母
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach 期刊论文 ZJ Zhong;ZP Yao;ZQ Shi;YD Liu;LF Liu;GZ Xin
2 In silico production of relative correction factor for the quantitative analysis of multi-components by single marker method 期刊论文 Yin Ying-Hao;Zheng Jia-Yi;Wang Xin-Nan;Qian Sheng-Ying;Liu Xu-Yi;Liu Li-Fang;Xin Gui-Zhong
3 A novel liquid-liquid-solid microextraction strategy for bio-sample preparation by in situ self-assembly of zeolitic imidazolate framework 8 on hollow fiber membrane 期刊论文 Liu Yang-Dan;Xin Gui-Zhong;Li Wei;Liu Feng-Jie;Yao Zhong-Ping;Di Xin
4 川贝母总苷在制备治疗哮喘药物中的用途 专利 辛贵忠;杨丽;刘丽芳;刘云
5 A readily O-16-/O-18-isotopically-paired chiral derivatization approach for the quantification of 2-HG metabolic panel by liquid chromatography-Tandem mass spectrometry 期刊论文 Zheng Jia-Yi;Jiang Xue;Zhou Jian-Liang;Shi Zi-Qi;Liu Li-Fang;Xin Gui-Zhong
6 Ammonium fluoride-induced stabilization for anion attachment mass spectrometry: Facilitating the pseudotargeted profiling of bile acids submetabolome 期刊论文 Cheng Xian;Zhou Jian-Liang;Shi Zi-Qi;Yin Ying-Hao;Liu Jian-Qun;Chen Han-Xiang;Li Ping;Liu Li-Fang;Xin Gui-Zhong
7 Fluorous-paired derivatization approach towards highly sensitive and accurate determination of long chain unsaturated fatty acids by liquid chromatography-tandem mass spectrometry 期刊论文 Zheng Jia-Yi;Jin Ying-Ying;Shi Zi-Qi;Zhou Jian-Liang;Liu Li-Fang;Xin Gui-Zhong
8 Orthogonal label and label-free dual pretreatment for targeted profiling of neurotransmitters in enteric nervous system 期刊论文 XN Wang;JQ Liu;ZQ Shi;FY Sun;LF Liu;GZ Xin
9 A chemical derivatization based UHPLC-LTQ-Orbitrap mass spectrometry method for accurate quantification of short-chain fatty acids in bronchoalveolar lavage fluid of asthma mice 期刊论文 Ying-Ying Jin;Zi-Qi Shi;Wen-Qi Chang;Lin-Xiu Guo;Jian-Liang Zhou;Jian-Qun Liu;Li-Fang Liu;Gui-Zhong Xin
10 Comparative analysis and natural evolution of squalene epoxidase in threeFritillariaspecies 期刊论文 Lu Xu;Zhang Lin-Ning;Du Jin-Fa;Zheng Xiao-Yan;Li Hui-Jun;Li Ping;Xin Gui-Zhong;Jiang Yan
11 Untargeted metabolomics coupled with chemometric analysis reveals species-specific steroidal alkaloids for the authentication of medicinal Fritillariae Bulbus and relevant products 期刊论文 Liu Feng-Jie;Jiang Yan;Li Ping;Liu Yang-Dan;Yao Zhong-Ping;Xin Gui-Zhong;Li Hui-Jun
12 Saponins from Clematis mandshurica Rupr. regulates gut microbiota and its metabolites during alleviation of collagen-induced arthritis in rats 期刊论文 Guo Lin-Xiu;Wang Huai-You;Liu Xue-Duan;Zheng Jia-Yi;Tang Qi;Wang Xin-Nan;Liu Jian-Qun;Yin Hua-Qun;Miao Bo;Liang Yi-Li;Liu Li-Fang;Xin Gui-Zhong
13 Development and validation of a systematic platform for broad-scale profiling of microbial metabolites 期刊论文 Wang Xin-Nan;Yin Ying-Hao;Cheng Xian;Chen Lin;Chen Meng-Lu;Zheng Jia-Yi;Jin Ying-Ying;Liu Jian-Qun;Liu Li-Fang;Xin Gui-Zhong
14 Diagnostic fragmentation-assisted mass spectral networking coupled with in silico dereplication for deep annotation of steroidal alkaloids in medicinal Fritillariae Bulbus 期刊论文 Feng-Jie Liu;Yan Jiang;Ping Li;Yang-Dan Liu;Gui-Zhong Xin;Zhong-Ping Yao;Hui-Jun Li
15 Development and validation of a LC/MS-based method for the measurement of intracellular superoxide anion 期刊论文 Wang Ze-Yuan;Li Yi;Chang Wen-Qi;Zheng Jia-Yi;Li Ping;Liu Li-Fang;Xin Gui-Zhong
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