DT-13基于NMIIA—EGFR/C2GnT-M—HKII联合TPT调节肿瘤有氧糖酵解抗胃癌作用机制研究
81773766
2017
H3505.抗肿瘤药物药理
袁胜涛
面上项目
研究员
中国药科大学
48万元
非肌肉肌球蛋白IIA;有氧糖酵解;表皮生长因子受体;联合用药;己糖激酶II
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway | 期刊论文 | Hou Xiaoying;Du Hongzhi;Quan Xingping;Shi Lei;Zhang Qianqian;Wu Yao;Liu Yang;Xiao Jing;Li Yong;Lu Ligong;Ai Xun;Zhan Meixiao;Yuan Shengtao;Sun Li |
| 2 | I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo | 期刊论文 | Jia Panli;Wu Yao;Du Hongzhi;Yang Lijun;Zhang Zhibo;Ma Tianfang;Li Sun;Yuan Shengtao;Lu Ligong;Zha Xiaoming |
| 3 | Camellia nitidissima Chi Extract Potentiates the Sensitivity of Gastric Cancer Cells to Paclitaxel via the Induction of Autophagy and Apoptosis | 期刊论文 | He Xu;Li Hang;Zhan Meixiao;Li Hongyang;Jia Aiqun;Lin Sensen;Sun Li;Du Hongzhi;Yuan Shengtao;Li Yong |
| 4 | The role of ASCT2 in cancer: A review | 期刊论文 | Yang Liu;Tingli Zhao;Zhengzheng Li;Lai Wang;Shengtao Yuan;Li Sun |
| 5 | Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner | 期刊论文 | Wu Yao;Du Hongzhi;Zhan Meixiao;Wang Hongxv;Chen Peng;Du Danyu;Liu Xinyi;Huang Xingxv;Ma Pengcheng;Peng Dezheng;Sun Li;Yuan Shengtao;Ding Jian;Lu Ligong;Jiang Jingwei |
| 6 | C118P, a novel microtubule inhibitor with anti-angiogenic and vascular disrupting activities, exerts anti-tumor effects against hepatocellular carcinoma. | 期刊论文 | Shihui Wei;Liwen Zhao;Zhiling Zhou;Xian Zhang;Mei Yang;Zhengguang Liao;Luwei Han;Yanhong Su;Meixiao Zhan;Zhiqiang Wang;Li Sun;Danyu Du;Jingwei Jiang;Shengtao Yuan;Qian Zhang |
| 7 | A Novel Camptothecin Derivative 3j Inhibits NSCLC Proliferation via Induction of Cell Cycle Arrest by Topo I-Mediated DNA Damage | 期刊论文 | Liu Yang;Zhang Jingyin;Feng Shuyun;Zhao Tingli;Li Zhengzheng;Wang Lai;Wang Puhai;Du Hongzhi;Yuan Shengtao;Sun Li |
| 8 | DT-13 inhibits breast cancer cell migration via non-muscle myosin II-A regulation in tumor microenvironment synchronized adaptations | 期刊论文 | Gao Y.;Khan G. J.;Wei X.;Zhai K-F;Sun L.;Yuan S. |
| 9 | 抗凋亡蛋白Mcl-1及其抑制剂的研究进展 | 期刊论文 | 赵廷丽;刘阳;李征征;王来;孙立;袁胜涛 |
| 10 | Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling | 期刊论文 | Wei Xiaohui;Li Sijing;He Jinyong;Du Hongzhi;Liu Yang;Yu Wei;Hu Haolin;Han Lifei;Wang Chenfei;Li Hongyang;Shi Xin;Zhan Meixiao;Lu Ligong;Yuan Shengtao;Sun Li |
| 11 | Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance | 期刊论文 | Quan Xingping;Du Hongzhi;Xu Jingjing;Hou Xiaoying;Gong Xiaofeng;Wu Yao;Zhou Yuqi;Jiang Jingwei;Lu Ligong;Yuan Shengtao;Yang Xiangyu;Shi Lei;Sun Li |
| 12 | Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo | 期刊论文 | Du Hongzhi;Huang Yue;Hou Xiaoying;Quan Xingping;Jiang Jingwei;Wei Xiaohui;Liu Yang;Li Hongyang;Wang Puhai;Zhan Meixiao;Ai Xun;Lu Ligong;Yuan Shengtao;Sun Li |
| 13 | DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment | 期刊论文 | He Jinyong;Wei Xiaohui;Li Sijing;Quan Xingping;Li Ruiming;Du Hongzhi;Yuan Shengtao;Sun Li |
| 14 | Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression | 期刊论文 | Jin-Yong He;Xiao-Hui Wei;Si-Jing Li;Yang Liu;Hao-Lin Hu;Zheng-Zheng Li;Xin-Hong Kuang;Lai Wang;Xin Shi;Sheng-Tao Yuan;Li Sun |
| 15 | Sepiapterin reductase: Characteristics and role in diseases | 期刊论文 | Wu Yao;Chen Peng;Sun Li;Yuan Shengtao;Cheng Zujue;Lu Ligong;Du Hongzhi;Zhan Meixiao |
| 16 | The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer | 期刊论文 | Xiaofeng Gong;Danyu Du;Yanran Deng;Yuqi Zhou;Li Sun;Shengtao Yuan |
| 17 | Adipocyte-Derived Leptin Promotes PAI-1-Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner | 期刊论文 | Xue-Mei Tian;Li Sun;Yu-Qi Zeng;Xiao-Man Zhan;Xiao-Hui Wei;Jin-Yong He;Sheng-Tao Yuan;Si-Jing Li |
| 18 | Pharmacological effects and potential therapeutic targets of DT-13 | 期刊论文 | Ghulam Jilany Khan;Mohsin Rizwan;Muhammad Abbas;Muhammad Naveed;Yu Boyang;Muhammad Ahsan Naeem;Sara Khan;Shengtao Yuan;Mirza Muhammad Faran Ashraf Baig;Li Sun |
| 19 | DT-13 inhibited the proliferation of colorectal cancer via glycolytic metabolism and AMPK/mTOR signaling pathway | 期刊论文 | Wei Xiaohui;Mao Tingting;Li Sijing;He Jinyong;Hou Xiaoying;Li Hongyang;Zhan Meixiao;Yang Xiangyu;Li Ruiming;Xiao Jing;Yuan Shengtao;Sun Li |
| 20 | PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC | 期刊论文 | Du Hongzhi;Chen Yulong;Hou Xiaoying;Huang Yue;Wei Xiaohui;Yu Xiaowen;Feng Shuyun;Wu Yao;Zhan Meixiao;Shi Xin;Lin Sensen;Lu Ligong;Yuan Shengtao;Sun Li |
| 21 | Topotecan induces apoptosis via ASCT2 mediated oxidative stress in gastric cancer | 期刊论文 | Wang Lai;Liu Yang;Zhao Ting-Li;Li Zheng-Zheng;He Jin-Yong;Zhang Ben-Jia;Du Hong-Zhi;Jiang Jing-Wei;Yuan Sheng-Tao;Sun Li |
| 22 | PIM-1激酶抑制剂研究进展 | 期刊论文 | 周育奇;龚晓峰;全兴萍;侯晓莹;杜鸿志;孙立;袁胜涛 |
| 23 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China | 期刊论文 | Wang Zhiqiang;Zhang Zhibo;Li Yong;Sun Li;Peng Dezhen;Du Danyu;Zhang Xian;Han Luwei;Zhao Liwen;Lu Ligong;Du Hongzhi;Yuan Shengtao;Zhan Meixiao |
| 24 | Synergistic combination of DT-13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC-823 cells via NM IIA/EGFR/HK II axis | 期刊论文 | Yu Xiao-Wen;Wei Dandan;Gao Ying-Sheng;Du Hong-Zhi;Yu Bo-Yang;Li Rui-Ming;Qian Chang-Min;Luo Xue-Jun;Yuan Sheng-Tao;Wang Jun-Song;Sun Li |
| 25 | DT-13 synergistically potentiates the sensitivity of gastric cancer cells to topotecan via cell cycle arrest in vitro and in vivo | 期刊论文 | Du Hongzhi;Liu Yang;Chen Xudong;Yu Xiaowen;Hou Xiaoying;Li Hongyang;Zhan Meixiao;Lin Sensen;Lu Ligong;Yuan Shengtao;Sun Li |
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