P2Y14R对急性痛风性关节炎的调控作用及先导化合物的靶向干预机制研究

81773745
2017
H3504.抗炎与免疫药物药理
胡庆华
面上项目
教授
中国药科大学
62万元
NETosis;焦亡;P2Y14R;急性痛风性关节炎;BPBC
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 嘌呤受体P2Y在免疫炎症中的功能研究进展 期刊论文 李瀚文;季晖;胡庆华
2 Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y(14)R antagonists with potential high efficiency against acute gouty arthritis 期刊论文 Lu Ran;Wang Yilin;Liu Chunxiao;Zhang Zhenguo;Li Baiyang;Meng Zibo;Jiang Cheng;Hu Qinghua
3 Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis 期刊论文 Jiang Fei;Hu Qinghua;Zhang Zhimin;Li Hongmei;Li Huili;Zhang Dewei;Li Hanwen;Ma Yu;Xu Jingjing;Chen Haifang;Cui Yong;Zhi Yanle;Zhang Yanmin;Xu Junyu;Zhu Jiapeng;Lu Tao;Chen Yadong
4 中性粒细胞胞外诱捕网及其参与的免疫炎症性疾病研究进展 期刊论文 刘春晓;胡庆华
5 GSDMD介导的细胞焦亡研究进展 期刊论文 叶淑敏;胡庆华
6 Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis 期刊论文 Wenjiao Jiang;Kun Hao;Mengze Zhou;Hanwen Li;Yadong Chen;Fei Jiang;Qinghua Hu
7 3-酰胺基苯甲酸衍生物、其制备方法及医药用途 专利 江程;胡庆华;张振国
8 党参炔苷在制备治疗糖尿病的药物中的应用 专利 胡庆华;李环球;方娅霏;刘春晓
9 Silencing of Gasdermin D by siRNA-Loaded PEI-Chol Lipopolymers Potently Relieves Acute Gouty Arthritis through Inhibiting Pyroptosis 期刊论文 Shu-Min Ye;Meng-Ze Zhou;Wen-Jiao Jiang;Chun-Xiao Liu;Zhan-Wei Zhou;Min-Jie Sun;Qing-Hua Hu
10 Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout 期刊论文 Huang Jun;Zhou Zehao;Zhou Mengze;Miao Mingxing;Li Huanqiu;Hu Qinghua
11 2,2-(4-羧基辛酰胺基)苯甲酸甲酯在制备治疗炎症性疾病药物中的应用 专利 胡庆华;李环球;周梦泽
12 Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats 期刊论文 Wu Hui;Zhou Mengze;Lu Guo;Yang Zhonglin;Ji Hui;Hu Qinghua
13 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3 期刊论文 Zhou Mengze;Li Suning;Song Ling;Hu Qinghua;Liu Wentao
14 P2Y(14) receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages 期刊论文 Li Hanwen;Jiang Wenjiao;Ye Shumin;Zhou Mengze;Liu Chunxiao;Yang Xiping;Hao Kun;Hu Qinghua
15 一种苯并呋喃类小分子P2Y14受体抑制剂,及其制备和应用 专利 胡庆华;李环球;刘春晓
16 Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential 期刊论文 Mengze Zhou;Weiwei Wang;Zhongkui Wang;Yilin Wang;Yifan Zhu;Zhiqian Lin;Sheng Tian;Yuan Huang;Qinghua Hu;Huanqiu Li
17 5-氨基-1H-吡唑衍生物、制备方法及医药用途 专利 江程;胡庆华;陆冉
18 Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y(14) receptor antagonists 期刊论文 Zhang Zhenguo;Hao Kun;Li Hanwen;Lu Ran;Liu Chunxiao;Zhou Mengze;Li Baiyang;Meng Zibo;Hu Qinghua;Jiang Cheng
19 Discovery of novel and potent P2Y14R antagonists via structure-based virtual screening for the treatment of acute gouty arthritis 期刊论文 Wang W;Liu C;Li H;Tian S;Liu Y;Wang N;Li H;Hu Q
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