五环三萜类新型ERRalpha激动剂的发现、生物活性评价及作用机制研究
81730094
2017
H3401.合成药物化学
孙宏斌
重点项目
教授
中国药科大学
290万元
雌激素相关受体alpha;非酒精性脂肪肝;氧化代谢;五环三萜;激动剂
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells | 期刊论文 | Yaping Huang;Geng Sun;Pengfei Wang;Rui Shi;Yanchun Zhang;Xiaoan Wen;Hongbin Sun;Caiping Chen |
| 2 | Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design | 期刊论文 | Ren Sheng;Liu Yang;Yanchun Zhang;Enming Xing;Rui Shi;Xiaoan Wen;Heyao Wang;Hongbin Sun |
| 3 | Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction | 期刊论文 | Hengzhi Sun;Jinzheng Wang;Shengjie Liu;Xinyu Zhou;Liang Dai;Caiping Chen;Qinglong Xu;Xiaoan Wen;Keguang Cheng;Hongbin Sun;Haoliang Yuan |
| 4 | Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation | 期刊论文 | Liang Dai;Zhiqi Feng;Rili Zha;Keguang Cheng;Xiaoan Wen;Hongbin Sun;Haoliang Yuan |
| 5 | Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis | 期刊论文 | Zhiqi Feng;Jiehao Xiang;Hui Liu;Jiaxin Li;Xiangrui Xu;Gang Sun;Runan Zheng;Shangran Zhang;Junlong Liu;Shanlin Yang;Qinglong Xu;Xiaoan Wen;Haoliang Yuan;Hongbin Sun;Liang Dai |
| 6 | AMPK 激动剂化合物或其药学上可接受的盐或酯或溶剂化物及其用途 | 专利 | 孙宏斌;李浩斌;尤燕平;程亚龙;钱铭;周鑫煜;温小安;陈彩萍;许庆龙;袁 浩亮 |
| 7 | Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression | 期刊论文 | Cai-Ping Chen;Kun Chen;Zhi-Qi Feng;Xiaoan Wen;Hongbin Sun |
| 8 | 苯并噻唑类化合物及医药用途 | 专利 | 孙宏斌;陈彩萍;周鑫煜;刘胜杰;袁浩亮;温小安 |
| 9 | Metabolism-Associated Molecular Patterns (MAMPs) | 期刊论文 | Xu Wang;Yi Wang;Victor Antony;Hongbin Sun;Guang Liang |
| 10 | Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid | 期刊论文 | Liu Liu;Haobin Li;Kaiwen Hu;Qinglong Xu;Xiaoan Wen;Keguang Cheng;Caiping Chen;Haoliang Yuan;Liang Dai;Hongbin Sun |
| 11 | A Selectivity Study of FFAR4/FFAR1 Agonists by Molecular Modeling. | 期刊论文 | Xiangying Zhang;Hongbin Sun;Xiaoan Wen;Haoliang Yuan |
| 12 | delta-齐墩果酸皂苷类化合物及其医药用途 | 专利 | 孙宏斌;李浩斌;刘柳;戴量;胡凯文;许庆龙;柳军;温小安 |
| 13 | Impaired Insulin Clearance as the Initial Regulator of Obesity-Associated Hyperinsulinemia: Novel Insight Into the Underlying Mechanism Based on Serum Bile Acid Profiles | 期刊论文 | Zhenzhen Fu;Qinyi Wu;Wen Guo;Jingyu Gu;Xuqin Zheng;Yingyun Gong;Chenyan Lu;Jingya Ye;Xuan Ye;Wanzi Jiang;Moran Hu;Baowen Yu;Qi Fu;Xiang Liu;Jianling Bai;John Zhong Li;Tao Yang;Hongwen Zhou |
| 14 | Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis | 期刊论文 | Ming Qian;Zhiqi Feng;Runan Zheng;Kaiwen Hu;Jiaze Sun;Hongbin Sun;Liang Dai |
| 15 | Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity | 期刊论文 | Liu Liu;Yao Zhiying;Wang Shijun;Xie Tao;Wu Guoqing;Zhang Honghan;Zhang Pu;Wu Yaojun;Yuan Haoliang;Sun Hongbin |
| 16 | Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation | 期刊论文 | Shengjie Liu;Xinyu Zhou;Minglei Li;Wenfeng Zhao;Shuxi Zhou;Keguang Cheng;Qinglong Xu;Caiping Chen;Xiaoan Wen;Hongbin Sun;Haoliang Yuan |
| 17 | 齐墩果酸的衍生物及其医药用途 | 专利 | 孙宏斌;程亚龙;温小安 |
| 18 | Discovery of Orally Bioavailable N-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer | 期刊论文 | Xing Li;Shanlin Yang;Honghan Zhang;Xipeng Liu;Yuchen Gao;Yuqi Chen;Liu Liu;Dalin Wang;Zijiang Liang;Shengjie Liu;Liang Dai;Qinglong Xu;Haoliang Yuan;Caiping Chen;Hongbin Sun;Xiaoan Wen |
| 19 | The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation. | 期刊论文 | Yanhong Pan;Yanping You;Li Sun;Qibang Sui;Liu Liu;Haoliang Yuan;Caiping Chen;Jun Liu;Xiaoan Wen;Liang Dai;Hongbin Sun |
| 20 | Discovery of a Novel Macrocyclic ATP Citrate Lyase Inhibitor | 期刊论文 | Yongjun Zang;Luyang Tai;Yuanyang Hu;Yu Wang;Hongbin Sun;Xiaoan Wen;Haoliang Yuan;Liang Dai |
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