基于ATF4和GRP78靶点研究酸浆中睡茄内酯类物质抑制人骨肉瘤化疗耐药发生的作用

81703754
2017
H3210.中药抗肿瘤药理
夏元铮
青年科学基金项目
副教授
中国药科大学
20万元
转录激活因子4;骨肉瘤;葡萄糖调节蛋白78;多药耐药;酸浆
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma 期刊论文 Luo Jie;Xia Yuanzheng;Yin Yong;Luo Jun;Liu Mingming;Zhang Hao;Zhang Chao;Zhao Yucheng;Yang Lei;Kong Lingyi
2 MicroRNA and long noncoding RNA involvement in gout and prospects for treatment 期刊论文 Yi-Ting Xu;Ying-Rong Leng;Ming-Ming Liu;Rui-Fang Dong;Jing Bian;Liu-Liu Yuan;Jian-guo Zhang;Yuan-Zheng Xia;Ling-Yi Kong
3 Physakengose G induces apoptosis via EGFR/mTOR signaling and inhibits autophagic flux in human osteosarcoma cells 期刊论文 Lin Hua;Zhang Chao;Zhang Hao;Xia Yuan Zheng;Zhang Chuan Yang;Luo Jie;Yang Lei;Kong Ling Yi
4 Vielanin K enhances doxorubicin-induced apoptosis via activation of IRE1α- TRAF2 - JNK pathway and increases mitochondrial Ca2 + influx in MCF-7 and MCF-7/MDR cells 期刊论文 Li-Na Zhang;Yuan-Zheng Xia;Chao Zhang;Hao Zhang;Jian-Guang Luo;Lei Yang;Ling-Yi Kong
5 Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site 期刊论文 Yin Yong;Lian Bao-Ping;Xia Yuan-Zheng;Shao Yu-Ying;Kong Ling-Yi
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