基于丹参酮小分子探针研究其抗血管内皮细胞氧化应激损伤的分子靶标及调控机制

81573705
2015
H3219.中药学研究新技术与新方法
陈君
面上项目
教授
中国药科大学
65万元
血管内皮细胞;靶标;丹参酮类成分;小分子探针;氧化应激损伤
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway 期刊论文 Yang Yu-Yu;Li Xue-Yan;Peng Li-Ying;An Lin;Sun Ning-Yuan;Hu Xue-Wen;Zhou Ping;Xu Yong;Li Ping;Chen Jun
2 Synthesis and biological evaluation of tanshinone IIA derivatives as novel endothelial protective agents 期刊论文 Bi Xiao-Ling;Zhang Kuo-Jun;He Long;Gao Biao;Gu Qin-Lan;Li Xue-Yan;Chen Jun;Wang Jin-Xin
3 丹参酮IIA衍生物在制备内皮细胞保护药物中的应用 专利 王进欣;陈君;何龙
4 A selective knockout method for discovery of minor active components from plant extracts: Feasibility and challenges as illustrated by an application to Salvia miltiorrhiza 期刊论文 Li Xue-Yan;Tang Hong-Jin;Zhang Liu;Yang Lin;Li Ping;Chen Jun
5 一种快速发现天然产物中低含量活性成分的新方法 专利 陈君;李雪岩;杨琳;李萍;张柳
6 Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis 期刊论文 An Lin;Peng Li-Ying;Sun Ning-Yuan;Yang Yi-Lin;Zhang Xiao-Wei;Li Bin;Liu Bao-Lin;Li Ping;Chen Jun
7 Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway 期刊论文 Zhang Liu;Zhang Hui;Li Xueyan;Jia Bingjie;Yang Yuyu;Zhou Ping;Li Ping;Chen Jun
8 Molecular modelling studies of 3,5-dipyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors using 3D-QSAR, Topomer CoMFA, molecular docking and molecular dynamic simulations 期刊论文 Tang Hong-jin;Yang Lin;Li Jia-huang;Chen Jun
9 中药抗巨噬细胞泡沫化的研究进展 期刊论文 李雪岩;杨玉玉;陈君
10 Discovery of cancer cell proliferation inhibitors from Salviae miltiorrhizae radix et rhizoma by a trace peak enrichment approach 期刊论文 Zhang Xiao-wei;Yang Lin;An Lin;Li Ping;Chen Jun
11 Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C 期刊论文 Tang Hong-Jin;Zhang Xiao-Wei;Yang Lin;Li Wei;Li Jia-Huang;Wang Jin-Xin;Chen Jun
12 Salvia miltiorrhiza Lipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy Through Activation of Nuclear Factor Erythroid 2-Related Factor 2 期刊论文 An Lin;Zhou Mei;Marikar Faiz M. M. T.;Hu Xue-Wen;Miao Qiu-Yun;Chen Jun
13 Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold 期刊论文 Hong-Jin Tang;Wei Li;Mei Zhou;Li-Ying Peng;Jin-Xin Wang;Jia-Huang Li;Jun Chen
14 Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking 期刊论文 Tang Hongjin;Yang Lin;Li Wei;Li Jiahuang;Chen Jun
15 Salvia miltiorrhiza Restrains Reactive Oxygen Species-Associated Pulmonary Fibrosis via Targeting Nrf2-Nox4 Redox Balance 期刊论文 Peng Li-Ying;An Lin;Sun Ning-Yuan;Ma Yi;Zhang Xiao-Wei;Liu Wen-hua;Liu Bao-Lin;Li Ping;Chen Jun
16 Ultra-high performance liquid chromatography with ultraviolet and tandem mass spectrometry for simultaneous determination of metabolites in purine pathway of rat plasma 期刊论文 Lu Jin-Jin;Jia Bing-Jie;Yang Lin;Zhang Wen;Dong Xin;Li Ping;Chen Jun
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