雌激素及胆汁酸基于cAMP-AMPK-HNF1α-FXR通路调控胆汁淤积的作用机制研究
81573514
2015
H3512.药物毒理
江振洲
面上项目
研究员
中国药科大学
50万元
胆汁淤积;雌激素;胆汁酸;AMP依赖性蛋白激酶;法尼醇X受体
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment | 期刊论文 | Hozeifa Mohamed Hassan;Guo Hongli;Bashir Alsiddig Yousef;Mounia Guerram;Aida Mejda Hamdi;Zhang Luyong;Jiang Zhenzhou |
| 2 | Investigating the CYP2E1 potential role in the mechanisms behind INH/LPS-induced hepatotoxicity | 期刊论文 | Hozeifa Mohamed Hassan;Bashir Alsiddig Yousef;Guo Hongli;Liu Xiaoxin;Zhang Luyong;Jiang Zhenzhou |
| 3 | The Duality of Kupffer Cell Responses in Liver Metabolic States | 期刊论文 | Liu Xiaoxin;Yu Linxi;Waseem Hassan;Sun Lixin;Zhang Luyong;Jiang Zhengzhou |
| 4 | Role of AMP-activated protein kinase alpha 1 in 17 alpha-ethinylestradiol-induced cholestasis in rats | 期刊论文 | Li Xiaojiaoyang;Liu Runping;Luo Lan;Yu Linxi;Chen Xin;Sun Lixin;Wang Tao;Phillip B. Hylemon;Zhou Huiping;Jiang Zhenzhou;Zhang Luyong |
| 5 | Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats | 期刊论文 | Yang Jing;Sun Lixin;Wang Lu;Hozeifa Mohamed Hassan;Wang Xuan;Phillip B. Hylemon;Wang Tao;Zhou Huiping;Zhang Luyong;Jiang Zhenzhou |
| 6 | SRT1720 alleviates ANIT-induced cholestasis in a mouse model | 期刊论文 | Yu Linxi;Liu Xiaoxin;Yuan Zihang;Li Xiaojiaoyang;Yang Hang;Yuan Ziqiao;Lixin Sun;Zhang Luyong;Jiang Zhenzhou |
| 7 | UDCA and CDCA alleviate 17 alpha-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats | 期刊论文 | Li Xiaojiaoyang;Yuan Zihang;Liu Runping;Hozeifa M. Hassan;Yang Hang;Sun Rong;Zhang Luyong;Jiang Zhenzhou |
| 8 | Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis | 期刊论文 | Yang Tingting;Mei Huifang;Xu Dengqiu;Zhou Wang;Zhu Xiaoyu;Sun Lixin;Huang Xin;Wang Xue;Shu Ting;Liu Jia;Ding Jiaxin;Hozeifa M. Hassan;Zhang Luyong;Jiang Zhenzhou |
| 9 | Dexamethasone Pretreatment Alleviates Isoniazid/Lipopolysaccharide Hepatotoxicity: Inhibition of Inflammatory and Oxidative Stress | 期刊论文 | Hozeifa M. Hassan;Guo Hongli;Bashir A. Yousef;Ding Pingping;Zhang Luyong;Jiang Zhenzhou |
| 10 | Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis | 期刊论文 | Yang Tingting;Mei Huifang;Xu Dengqiu;Zhou Wang;Zhu Xiaoyu;Sun Lixin;Huang Xin;Wang Xue;Shu Ting;Liu Jia;Ding Jiaxin;Hozeifa M. Hassan;Zhang Luyong;Jiang Zhenzhou |
| 11 | Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment | 期刊论文 | Hozeifa Mohamed Hassan;Guo Hongli;Bashir Alsiddig Yousef;Mounia Guerram;Aida Mejda Hamdi;Zhang Luyong;Jiang Zhenzhou |
| 12 | SRT1720 alleviates ANIT-induced cholestasis in a mouse model | 期刊论文 | Yu Linxi;Liu Xiaoxin;Yuan Zihang;Li Xiaojiaoyang;Yang Hang;Yuan Ziqiao;Lixin Sun;Zhang Luyong;Jiang Zhenzhou |
| 13 | Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease | 期刊论文 | Yu Qinwei();Jiang Zhenzhou();Zhang Luyong() |
| 14 | UDCA and CDCA alleviate 17 alpha-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats | 期刊论文 | Li Xiaojiaoyang;Yuan Zihang;Liu Runping;Hozeifa M. Hassan;Yang Hang;Sun Rong;Zhang Luyong;Jiang Zhenzhou |
| 15 | Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes | 期刊论文 | Li Xiaojiaoyang();Liu Runping;Yu Linxi;Yuan Zihang;Sun Rong;Yang Hang;Zhang Luyong;Jiang Zhenzhou() |
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