中药复杂组群代谢与药效机制桥接新理论及方法研究

81530098
2015
H3216.中药代谢与药物动力学
王广基
重点项目
教授
中国药科大学
273万元
中药复杂组群;生脉方;代谢谱效关系;多向代谢;中药代谢
2016-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification 期刊论文 Lin Wang;Hui Ye;Di Sun;Tuo Meng;Lijuan Cao;Mengqiu Wu;Min Zhao;Yun Wang;Baoqiang Chen;Xiaowei Xu;Guangji Wang;Haiping Hao
2 细胞药代动力学新理论技术体系的创建及其在新药研发和临床用药中的应用 奖励 王广基;张经纬;周芳;郝海平;阿基业;孙建国;郝琨;梁艳;彭英;甄乐
3 The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs 期刊论文 Lixiang Aa;Fei Fei;Zhaoyi Tan;Jiye Aa;Guangji Wang;Changxiao Liu
4 SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis. 期刊论文 Jiyu Zhou;Shuang Cui;Qingxian He;Yitong Guo;Xiaojie Pan;Pengfei Zhang;Ningning Huang;Chaoliang Ge;Guangji Wang;Frank J. Gonzalez;Hong Wang;Haiping Hao
5 Low cerebral exposure cannot hinder the neuroprotective effects of panax notoginsenosides 期刊论文 Haofeng Li;Jingcheng Xiao;Xinuo Li;Huimin Chen;Dian Kang;Yuhao Shao;Boyu Shen;Zhangpei Zhu;Xiaoxi Yin;Lin Xie;Guangji Wang;Yan Liang
6 Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota 期刊论文 Yue Zhang;Jianliang Geng;Yu Hong;Li Jiao;Shuning Li;Runbin Sun;Yuan Xie;Caixia Yan;Jiye Aa;Guangji Wang
7 A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut. 期刊论文 Yuanlong Hou;Wei Wei;Xiaojing Guan;Yali Liu;Gaorui Bian;Dandan He;Qilin Fan;Xiaoying Cai;Youying Zhang;Guangji Wang;Xiao Zheng;Haiping Hao
8 An auxiliary matrix for routine analysis of small molecules and biological macromolecules using matrix-assisted laser desorption ionization mass spectrometry 期刊论文 Zhangpei Zhu;Jiajia Shen;Dawei Wang;Chong Chen;Yangfan Xu;Huimin Guo;Dian Kang;Naoki Hamada;Jing Dong;Guangji Wang;Yan Liang
9 丹皮酚的全新结构活性代谢物 专利 王广基;孙建国;仲云熙;金孝亮;谷世寅;阿基业;彭英;王瑜
10 红参麦冬组合物在制备化疗药物增强剂中的应用 专利 宓寅筱;王广基;周芳;张经纬;刘文玥;刘文玥
11 Ginsenoside Rb1 exerts neuroprotective effects through regulation of Lactobacillus helveticus abundance and GABA A receptor expression 期刊论文 Huimin Chen;Jiajia Shen;Haofeng Li;Xiao Zheng;Dian Kang;Yangfan Xu;Chong Chen;Huimin Guo;Lin Xie;Guangji Wang;Yan Liang
12 Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity 期刊论文 Caixia Yan;Huimin Guo;Qingqing Ding;Yuhao Shao;Dian Kang;Tengjie Yu;Changjian Li;Haoran Huang;Yisha Du;He Wang;Kangrui Hu;Lin Xie;Guangji Wang;Yan Liang
13 Stepped collisional energy MS(All): an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties 期刊论文 Hui Ye;Lin Wang;Lin Zhu;Di Sun;Xiaozhuo Luo;Hong Wang;Guangji Wang;Haiping Hao
14 An improved detection and identification strategy for untargeted metabolomics based on UPLC-MS 期刊论文 Yuanlong Hou;Dandan He;Ling Ye;Guangji Wang;Qiuling Zheng;Haiping Hao
15 The improved performance of MALDI-TOF MS on the analysis of herbal saponins by using DHB-GO composite matrix 期刊论文 Zhangpei Zhu;Jiajia Shen;Yangfan Xu;Huimin Guo;Dian Kang;Tengjie Yu;He Wang;Wenshuo Xu;Guangji Wang;Yan Liang
16 Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study 期刊论文 Nan Aa;Jiahua Gu;Bei Cao;Runbin Sun;Xiaohui Ma;Yang Chu;Shuiping Zhou;Jiye Aa;Zhijian Yang;He Sun;Guangji Wang
17 Systematically identifying the hepatoprotective ingredients of schisandra lignan extract from pharmacokinetic and pharmacodynamic perspectives 期刊论文 Kang Dian;Shao Yuhao;Zhu Zhangpei;Yin Xiaoxi;Shen Boyu;Chen Chong;Xu Yangfan;Shen Jiajia;Li Haofeng;Li Xinuo;Xie Lin;Wang Guangji;Liang Yan
18 UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: a systematic review of UGT isoforms for precision medicine 期刊论文 Na Yang;Runbin Sun;Xiaoying Liao;Jiye Aa;Guangji Wang
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