肿瘤微环境pH敏感的生物破膜剂及其纳米药物载体的溶酶体逃逸功能研究

81503027
2015
H3409.药物材料
肖衍宇
青年科学基金项目
副教授
中国药科大学
18万元
敏感;抗肿瘤作用;纳米载体;氨基酸酯;pH;溶酶体逃逸
2016-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability 期刊论文 Xin Jin;Sajid Asghar;Mei Zhang;Zhipeng Chen;Lin Huang;Qineng Ping;Yanyu Xiao
2 N-acetyl-L-cysteine functionalized nanostructured lipid carrier for improving oral bioavailabilityof curcumin: preparation, in vitro and in vivo evaluations 期刊论文 Cihui Tian;Sajid Asghar;Yifan Wu;Kambere Amerigos Daddy;Zhipeng Chen;Mei Zhang;Lining Yin;Lin Huang;Qineng Ping;Yanyu Xiao
3 The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells 期刊论文 Cihui Tian;Sajid Asghar;Yurui Xu;Zhipeng Chen;Mei Zhang;Lin Huang;Junxiu Ye;Qineng Ping;Yanyu Xiao
4 In vitro and in vivo evaluation of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate) nanoparticles prepared by miniemulsion polymerization 期刊论文 Xin Jin;Sajid Asghar;Xieting Zhu;Zhipeng Chen;Cihui Tian;Lining Yin;Qineng Ping;Yanyu Xiao
5 一种在胃肠道具有高度稳定性的口服白蛋白纳米粒 专利 肖衍宇;於锋;杨柳;黄林
6 Chitosan hydrochloride/hyaluronic acid nanoparticles coated by mPEG as long-circulating nanocarriers for systemic delivery of mitoxantrone 期刊论文 Jiajia Wang;Sajid Asghar;Liu Yang;Shiya Gao;Zhipeng Chen;Lin Huang;Li Zong;Qineng Ping;Yanyu Xiao
7 Mitoxantrone-loaded chitosan/hyaluronate polyelectrolyte nanoparticles decorated with amphiphilic PEG derivates for long-circulating effect 期刊论文 Jiajia Wang;Sajid Asghar;Xin Jin;Zhipeng Chen;Lin Huang;Qineng Ping;Li Zong;Yanyu Xiao
8 Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting 期刊论文 Fanfei Meng;Sajid Asghar;Yurui Xu;Jianping Wang;Xin Jin;Zhilin Wang;Jing Wang;Qineng Ping;Jianping Zhou;Yanyu Xiao
9 Tween 80-modified hyaluronic acid-ss-curcumin micelles for targeting glioma: Synthesis, characterization and their in vitro evaluation 期刊论文 Cihui Tian;Sajid Asghar;Yurui Xu;Zhipeng Chen;Jingwei Zhang;Qineng Ping;Yanyu Xiao
10 一种用于口服给药的N‑乙酰基‑L‑半胱氨酸修饰的姜黄素纳米脂质载体 专利 肖衍宇;余艾玲;吴亦凡;王芝林;於锋;金鑫
11 Nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG containing curcumin: in vitro evaluation and pharmacokinetics in rats 期刊论文 Yurui Xu;Sajid Asghar;Liu Yang;Zhipeng Chen;Hongying Li;Wenwen Shi;Yibo Li;Qinqing Shi;Qineng Ping;Yanyu Xiao
12 Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid modified nanostructured lipid carriers 期刊论文 Cihui Tian;Sajid Asghar;Yifan Wu;Zhipeng Chen;Xin Jin;Lining Yin;Lin Huang;Qineng Ping;Yanyu Xiao
13 Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor 期刊论文 Yurui Xu;Sajid Asghar;Shiya Gao;Zhipeng Chen;Lin Huang;Lining Yin;Qineng Ping;Yanyu Xiao
14 Preparation of a paclitaxel-loaded cationic nanoemulsome and itsbiodistribution via direct intratumoral injection 期刊论文 Yurui Xu;Sajid Asghar;Hongying Li;Minglei Chen;Zhigui Su;Yangfan Xu;Qineng Ping;Yanyu Xiao
15 Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma 期刊论文 Yurui Xu;Sajid Asghar;Liu Yang;Hongying Li;Zhilin Wang;Qineng Ping;Yanyu Xiao
16 Enhanced oral bioavailability of 10-hydroxycamptothecin through the use of poly (n-butyl cyanoacrylate) nanospheres 期刊论文 Xin Jin;Sajid Asghar;Xieting Zhu;Zhipeng Chen;Junhong Liu;Yibo Li;Hongying Li;Qineng Ping;Yanyu Xiao
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