受体N-糖链对GLP-1防治糖尿病认知障碍的影响及机制

81473216
2014
H3503.老年病药物药理
高向东
面上项目
教授
中国药科大学
80万元
N-乙酰氨基葡萄糖转移酶;糖尿病认知障碍;N-糖链;胰高血糖素样肽-1受体
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis. 期刊论文 Yin Jun;Bao Lichen;Chen Rong;Gao Wen;Gao Xiangdong;Yao Wenbing
2 GLP-1 对 RAGE 介导 Alzheimer 样 tau 病变的作用及机理 会议论文 陈松;王影;汤茜;安凤毛;姚文兵;高向东
3 Glucagon-like peptide-1 regulates mitochondrial biogenesis and tau phosphorylation against advanced glycation end product-induced neuronal insult: Studies in vivo and in vitro. 期刊论文 An F-M;Chen S;Xu Z;Yin L;Wang Y;Liu A-R;Yao W-B;Gao X-D
4 Preparation, characterization, and alpha-glycosidase inhibition activity of a carboxymethylated polysaccharide from the residue of Sarcandra glabra (Thunb.) Nakai. 期刊论文 Liu Wei;Hu Cheng;Liu Yameng;Dai Shijie;Lu Weisheng;Lv Xing;Yao Wenbing;Gao Xiangdong
5 Structure, chain conformation, and immunomodulatory activity of the polysaccharide purified from Bacillus Calmette Guerin formulation. 期刊论文 Liu Wei;Wang Hong;Yu Juping;Liu Yameng;Lu Weisheng;Chai Yin;Liu Chao;Pan Chun;Yao Wenbing;Gao Xiangdong
6 Multiple fingerprint profiles and chemometrics analysis of polysaccharides from Sarcandra glabra. 期刊论文 Li Huan;Gong Xingqun;Wang Zichen;Pan Chun;Zhao Yang;Gao Xiangdong;Liu Wei
7 A polysaccharide extracted from Astragalus membranaceus residue improves cognitive dysfunction by altering gut microbiota in diabetic mice. 期刊论文 Liu Yameng;Liu Wei;Li Jing;Tang Shuai;Wang Majie;Huang Wenhua;Yao Wenbing;Gao Xiangdong
8 Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide. 期刊论文 Yin Jun;Wang Qun;Hou Shan;Bao Lichen;Yao Wenbing;Gao Xiangdong
9 TAT-FGF21融合蛋白的构建表达纯化及神经保护活性 期刊论文 陈苏婷;陈松;高向东
10 Conjugation of paclitaxel to C-6 hexanediamine-modified hyaluronic acid for targeted drug delivery to enhance antitumor efficacy. 期刊论文 Chen Yangjian;Peng Fujun;Song Xiaoda;Wu Jicheng;Yao Wenbin;Gao Xiangdong
11 Structure characterization, chemical and enzymatic degradation, and chain conformation of an acidic polysaccharide from Lycium barbarum L. 期刊论文 Liu Wei;Liu Yameng;Zhu Rui;Yu Juping;Lu Weisheng;Pan Chun;Yao Wenbing;Gao Xiangdong
12 Immunomodulatory effects of polysaccharide from marine fungus Phoma herbarum YS4108 on T cells and dendritic cells. 期刊论文 Chen Song;Ding Ran;Zhou Yan;Zhang Xian;Zhu Rui;Gao Xiang-Dong
13 Characterization and hypoglycemic effect of a neutral polysaccharide extracted from the residue of Codonopsis Pilosula. 期刊论文 Liu Wei;Lv Xing;Huang Wenhua;Yao Wenbing;Gao Xiangdong
14 Evidence of metabolic memory-induced neurodegeneration and the therapeutic effects of glucagon-like peptide-1 receptor agonists via Forkhead box class O. 期刊论文 Chen Song;Tang Qian;Wang Ying;Xu Zheng;Chen Su-Ting;Sun Yan;Yao Wen-Bing;Gao Xiang-Dong
15 丝素肽对Aβ25-35致SH-SY5Y细胞损伤的保护作用及机制研究 期刊论文 尉海洋;陈松;徐政;高向东;姚文兵
16 Neuroprotective effects of silk fibroin hydrolysate against Aβ25–35 induced cytotoxicity in SH-SY5Y cells and primary hippocampal neurons by regulating ROS inactivation of PP2A 期刊论文 Zheng Xu;Song Chen;Ying Wang;Su-Ting Chen;Wen-Bing Yao;Xiang-Dong Gao
17 Inhibiting receptor for advanced glycation end product (AGE) and oxidative stress involved in the protective effect mediated by glucagon-like peptide-1 receptor on AGE induced neuronal apoptosis. 期刊论文 Chen Song;Yin Lei;Xu Zheng;An Feng-Mao;Liu Ai-Ran;Wang Ying;Yao Wen-Bing;Gao Xiang-Dong
18 GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3beta/beta-catenin signaling. 期刊论文 Wang Ying;Chen Song;Xu Zheng;Chen Suting;Yao Wenbing;Gao Xiangdong
19 A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway. 期刊论文 Bao Lichen;Yin Jun;Gao Wen;Wang Qun;Yao Wenbing;Gao Xiangdong
20 Preliminary structural characterization and hypoglycemic effects of an acidic polysaccharide SERP1 from the residue of Sarcandra glabra. 期刊论文 Liu Wei;Lu Weisheng;Chai Yin;Liu Yameng;Yao Wenbing;Gao Xiangdong
21 基于“代谢记忆”的糖尿病并发症发生机制及其治疗药物研究进展 期刊论文 汤茜;陈松;高向东
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