整合PK/PD与代谢组学的黄连解毒汤体内药效物质基础研究

81430092
2014
H32.中药学
孔令义
重点项目
教授
中国药科大学
320万元
黄连解毒汤;体内药效物质基础;代谢组学;PK/PD;整合研究
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling 期刊论文 Wei Dan-Dan;Liao Shan-Ting;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
2 NMR metabolic profiling of lipopolysaccharide-induced mice sepsis and the treatment effects of berberine 期刊论文 Li Pei;Liao Shan-Ting;Wang Jun-Song;Xu Ding-Qiao;Zhang Qian;Yang Ming-Hua;Kong Ling-Yi
3 Study of the Cardiotoxicity of Venenum Bufonis in Rats using an 1H NMR-Based Metabolomics Approach 期刊论文 Dong Ge;Wei Dan-Dan;Wang Jun-Song;Guo Ping-Ping;Li Ming-Hui;Yang Ming-Hua;Kong Ling-Yi
4 The acute hepatotoxicity of tacrine explained by H-1 NMR based metabolomic profiling 期刊论文 Lou Yan-Hong;Wang Jun-Song;Dong Ge;Guo Ping-Ping;Wei Dan-Dan;Xie Sai-Sai;Yang Ming-Hua;Kong Ling-Yi
5 Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling 期刊论文 Lv Yan;Wang Jun-Song;Xu Ding-Qiao;Liao Shanting;Li Pei;Zhang Qian;Yang Minghua;Kong Ling-Yi
6 H-1 NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures 期刊论文 Li Pei;Wei Dan-Dan;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
7 H-1 NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window 期刊论文 Fu Xiao-Wei;Wang Jun-Song;Liao Shan-Ting;Lv Yan;Xu Ding-Qiao;Yang Ming-Hua;Kong Ling-Yi
8 Huang-Lian-Jie-Du decoction treated sepsis via regulating ERK and SRC/STAT3 pathways and ameliorating metabolic status 期刊论文 Liao Shan-Ting;Li Pei;Wang Jun-Song;Zhang Qian;Xu Ding-Qiao;Lv Yan;Yang Ming-Hua;Kong Ling-Yi
9 Toxicity assessment of Arisaematis Rhizoma in rats by a H-1 NMR-based metabolomics approach 期刊论文 Dong Ge;Wang Jun-Song;Guo Ping-Ping;Wei Dan-Dan;Yang Ming-Hua;Kong Ling-Yi
10 Chronic toxicity of crude ricinine in rats assessed by H-1 NMR metabolomics analysis 期刊论文 Guo Ping-Ping;Wei Dan-Dan;Wang Jun-Song;Dong Ge;Zhang Qian;Yang Ming-Hua;Kong Ling-Yi
11 Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction 期刊论文 Wei Dan-Dan;Wang Jun-Song;Duan Jin-Ao;Kong Ling-Yi
12 Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis 期刊论文 Zhang Qian;Wang Jun-Song;Liao Shan-Ting;Li Pei;Xu Ding-Qiao;Lv Yan;Yang Ming-Hua;Kong Ling-Yi
13 Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury 期刊论文 Li Pei;Liao Shan-Ting;Wang Jun-Song;Zhang Qian;Xu Ding-Qiao;Lv Yan;Yang Ming-Hua;Kong Ling-Yi
14 Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells 期刊论文 Lv Yan;Tian Na;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
15 Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-kappa B signaling 期刊论文 Xu Ding-Qiao;Lv Yan;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
16 Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach 期刊论文 Zhang Qian;Fu Xiao-Wei;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
17 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects 期刊论文 Liao Shan-Ting;Han Chao;Xu Ding-Qiao;Fu Xiao-Wei;Wang Jun-Song;Kong Ling-Yi
18 Gender-specific metabolic responses in focal cerebral ischemia of rats and Huang-Lian-Jie-Du decoction treatment 期刊论文 Zhang Qian;Guo Pingping;Wang Jun-Song;Yang Ming-Hua;Kong Ling-Yi
19 Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis 期刊论文 Xu Ding-Qiao;Liao Shan-Ting;Li Pei;Zhang Qian;Lv Yan;Fu Xiao-Wei;Yang Ming-Hua;Wang Jun-Song;Kong Ling-Yi
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