基于脏腑相合理论和代谢组学技术的大承气汤代谢调控及作用机制研究

81274108
2012
H3207.中药药性理论
张尊建
面上项目
教授
中国药科大学
73万元
大承气汤;生物标记物;肺合大肠;代谢组学;代谢网络
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Chemomic and chemometric approach based on ultra-fast liquid chromatography with ion trap time-of-flight mass spectrometry to reveal the difference in the chemical composition between Da-Cheng-Qi decoction and its three constitutional herbal medicines 期刊论文 Huang, Yin|Tian, Yuan|Xu, Fengguo|Zhang, Zunjian|
2 代谢组学信息获取与数据预处理瓶颈问题探讨 期刊论文 黄寅|张伟|张尊建|许风国|
3 Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism 期刊论文 Tian, Yuan|Xu, Fengguo|Song, Rui|Zhang, Zunjian|
4 Discovery of potential biomarkers with dose- and time-dependence in cisplatin- induced nephrotoxicity using metabolomics integrated with a principal component- based area calculation strategy 期刊论文 Yin Huang|Yuan Tian|Zunjian Zhang|Fengguo Xu|
5 Discrimination of crude and processed rhubarb products using a chemometric approach based on ultra fast liquid chromatography with ion trap/time-of-flight mass spectrometry. 期刊论文 Tian Yuan|Xu Fengguo|Song Rui|Zhang Zunjian|
6 A pharmacometabonomic approach using predose serum metabolite profiles reveals differences in lipid metabolism in survival and non-survival rats treated with lipopolysaccharide 期刊论文 Yin Huang|Wei Zhang|Fengguo Xu|Zunjian Zhang|
7 Time-resolved metabolomics analysis of individual differences during the early stage of lipopolysaccharide-treated rats 期刊论文 Jiaqing Chen|Yin Huang|Zunjian Zhang|Fengguo Xu|
8 Chemical differentiation of Da-Cheng-Qi decoction and its three analogous decoctions using UFLC-IT-TOF/MS-based chemomic and chemometric approach 期刊论文 Zhang, Qianqian|Tian, Yuan|Xu, Fengguo|Zhang, Zunjian|
9 药物代谢组学研究进展 期刊论文 许风国|张伟|王俊南|张尊建|
10 Targeted quantitative analysis of anthraquinone derivatives by high-performance liquid chromatography coupled to tandem mass spectrometry to discriminate crude and processed rhubarb samples 期刊论文 Mengying Lv|Fengguo Xu|Zunjian Zhang|Rui Song|
11 Pseudo-kinetics Approach for Time-Series Metabolomics Investigation: More Reliable and Sensitive Biomarkers Revealed in Vincristine-induced Paralytic Ileus Rat 期刊论文 Yin Huang|Wei Zhang|Fengguo Xu|Zunjian Zhang|
12 Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters 期刊论文 Guangnan Hu|Yuan Tian|Zunjian Zhang|Rui Song|
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