吡嗪酰胺大鼠肝毒性作用机制与毒性生物标志物研究

81273604
2012
H3512.药物毒理
江振洲
面上项目
研究员
中国药科大学
68万元
吡嗪酰胺;生物标志物;肝型脂肪酸结合蛋白;肝毒性;过氧化物酶体增生物激活受体α
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Emodin alleviates hepatic steatosis byinhibiting SREBP1 activity via the CaMKK-AMPK-mTOR-p70S6K signaling pathway 期刊论文 Guo Hongli|Wang Tao|Zhang Luyong|Jiang Zhenzhou|
2 吡嗪酰胺肝脏毒性的研究进展 期刊论文 张云|郭宏丽|张陆勇|江振洲|
3 Hepatotoxicity mechanisms of isoniazid: A mini-review 期刊论文 Guo Hongli|Bashir A. Yousef|Zhang Luyong|Jiang Zhenzhou|
4 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway 期刊论文 Wang Tao|Sun Lixin|Zhang Luyong|Jiang Zhenzhou|
5 Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae 期刊论文 Chen, Weiyun|Hsiao, Chung-Der|Zhang, Luyong|Jiang, Zhenzhou|
6 Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells 期刊论文 Hamdi, Aida M.|Wang, Bin|Zhang, Lu-Yong|Jiang, Zhen-Zhou|
7 Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport 期刊论文 Wang, Tao|Sun, Li-Xin|Zhang, Lu-Yong|Jiang, Zhen-Zhou|
8 Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury 期刊论文 Yuan Zihang|Yang Hang|Zhang Luyong|Jiang Zhenzhou|
9 Pyrazinamide induced hepatic injury in rats through inhibiting the PPAR alpha pathway 期刊论文 Wang, Tao|Sun, Lixin|Zhang, Luyong|Jiang, Zhenzhou|
10 Lipopolysaccharide exposure augments isoniazide-induced liver injury 期刊论文 Jiang Zhenzhou|Sun Lixin|Wang Tao|Zhang Luyong|
11 Role of inflammatory and oxidative stress, CYP2E1 and bile acid disturbance in ratliver injury induced by isoniazid and lipopolysaccharide co-treatment 期刊论文 Mounia Guerram|Aida Mejda Hamdi|Zhang Luyong|Jiang Zhenzhou|
12 Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes 期刊论文 Sun, Rong|Yang, Hang|Zhang, Luyong|Jiang, Zhenzhou|
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