【81271338】Nogo-66/NgR通路介导的神经炎症在阿尔茨海默氏病发病机制中的作用研究国家自然基金项目

Nogo-66/NgR通路介导的神经炎症在阿尔茨海默氏病发病机制中的作用研究

项目批准号： 81271338

批准年份： 2012

学科分类： H0909.神经系统炎症、感染及相关疾病

项目负责人：廖红

资助类别：面上项目

负责人职称：研究员

依托单位：中国药科大学

资助金额： 70万元

关键词： Nogo-66;Nogo;阿尔茨海默氏病;小胶质细胞;神经炎症;受体

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression	期刊论文	Chen Mingming\|Yin Zhiqi\|Zhang Luyong\|Liao Hong\|
2	Wnt信号通路在神经系统发育和神经系统疾病过程中的作用	期刊论文	刘美\|廖红\|
3	Expression of Nogo receptor 1 in microglia during development and following traumatic brain injury	期刊论文	Ni Jie\|Yan Ming\|Pang Tao\|Liao Hong\|
4	神经营养因子低亲和力受体p75NTR的表达及新药开发	期刊论文	倪婕\|刘高翔\|廖红\|
5	大麻素受体激动剂WIN55,212-2抑制脑缺血再灌后胶质瘢痕的形成	期刊论文	方吟荃\|宋曙\|张陆勇\|廖红\|
6	Screening of natural compounds with neuronal differentiation promoting effects in a cell-based model	期刊论文	Wang Jing\|Liu Mei\|Zhang Luyong\|Liao Hong\|
7	The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of A beta plaques and tau phosphorylation in APP/PS1 transgenic mice	期刊论文	Wang Jianing\|Chen Shujian\|Zhou Xin-fu\|Liao Hong\|
8	The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation	期刊论文	Yan Ming\|Zhang Luyong\|Mao Lei\|Liao Hong\|
9	Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection	期刊论文	Shi Xinzhong\|Pang Tao\|Zhang Luyong\|Liao Hong\|
10	Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition	期刊论文	An Lufan\|Pang Tao\|Shi Xinzong\|Liao Hong\|
11	脑卒中康复治疗的研究进展	期刊论文	李晨辉\|方吟荃\|陈明明\|廖红\|
12	Nafamostat Mesilate Improves Neurological Outcome and Axonal Regeneration after Stroke in Rats.	期刊论文	Sun Hao\|Tao Xia\|Zhou Xin-Fu\|Liao Hong\|
13	Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats	期刊论文	Chen Tao\|Sun Hao\|Zhou Xin-Fu\|Liao Hong\|
14	NgR1在中枢神经系统疾病中的作用研究进展	期刊论文	张哲\|严峻\|廖红\|
15	proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro	期刊论文	Wang Xiaobin\|Wang Yanjiang\|Zhou Xinfu\|Liao Hong\|
16	proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus	期刊论文	Chen Mingming\|Pang Tao\|Zhang Luyong\|Liao Hong\|
17	Nogo-66/ngr signal is involved in neuroinflammation through regulating microglia inflammatory mediators expression	会议论文	Yan Jun\|Zhang Zhe\|Zhou Xinfu\|Liao Hong\|
18	新药筛选核心技术规范化平台建设及其科学应用	奖励	张陆勇；尚靖；廖红；袁胜涛；柳军；江振州；严明；王涛；张评浒\|
19	Bilobalide Induces Neuronal Differentiation of P19 Embryonic Carcinoma Cells via Activating Wnt/beta-Catenin Pathway	期刊论文	Wang Juan\|Zhang Luyong\|Pang Tao\|Liao Hong\|
20	格列美脲通过下调β-分泌酶表达和活性降低Aβ水平	会议论文	刘飞扬\|廖红\|
21	Nogo-a inhibits adhesion and migration of microglia to ab in vitro	会议论文	Hong Liao\|YinQuan Fang\|
22	The role of NgR and P75NTR on the glia scar formation after traumatic brain injury	会议论文	Ni Jie\|Liu Gaoxiang\|Yan Jun\|Fang Yinquan\|
23	Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons	期刊论文	Yan Ming\|Zhang LuYong\|Pang Tao\|Liao Hong\|

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