一种具有抗动脉粥样硬化和抗糖尿病双功能蛋白的分子定向改造

30701023
2007
H3502.心脑血管药物药理
金亮
青年科学基金项目
教授
中国药科大学
18万元
抗动脉粥样硬化。;HSP65;定向改造;抗糖尿病
2008-01-01到2010-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration 期刊论文 Jin Liang|Liu Jingjing|Zhu Aihua|Wang Yu|Lu Yong|
2 A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice 期刊论文 Cao, Rongyue|Chen, Qingmei|Zhu, Aihua|Li, Taiming|Sun, Yunxiao|Jin, Liang|Xiong, Qiyan|Liu, Jingjing|Li, Jianping|Wang, Yu|Wu, Jie|
3 Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms 期刊论文 Xiong, Qiyan|Li, Taiming|Liu, Jingjing|Jin, Liang|Li, Jianping|
4 Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants 期刊论文 Wu Jie|Liu Jingjing|Xiong Qiyan|Cao Rongyue|Zhu Aihua|Chen Qingmei|Li Jianping|Jin Liang|Wang Yu|
5 Immunotherapy of Autoimmune Diabetes by Nasal Administration of Tandem Glutamic Acid Decarboxylase 65 Peptides 期刊论文 Jin, Liang|Fan, Hao|Sun, Yunxiao|Li, Taiming|Cao, Rongyue|Wang, Huaqian|Feng, Jiao|Lu, Yong|Yang, Jie|Wu, Jie|Liu, Jingjing|
6 Enhanced Immunogenicity of Peptide P277 by Heat Shock Protein HSP65 Vector Carrying Tandem Repeats of P277 to Prevent Type 1 Diabetes in NOD Mice 会议论文 Jingjing, L.|Yu, W.|Aihua, Z.|Liang, J.|
7 A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies 期刊论文 Jin, Liang|Li, Jianping|Fan, Hao|Xiong, Qiyan|Wu, Jie|Cao, Rongyue|Li, Taiming|Liu, Jingjing|
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