基于嘧啶与三嗪母核的PI3Kα/mTOR双靶点抑制剂的设计、合成及生物活性研究
序号 | 标题 | 类型 | 作者 |
---|---|---|---|
1 | Organocatalytic Asymmetric alpha-Sulfenylation of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral 2,2-Disubstituted Indole-3-ones with S- and N-Containing Heteroquaternary Carbon Stereocenter | 期刊论文 | Zhao Yong-Long;Fei Xing-Hai;Tang Yong-Qin;Xu Peng-Fei;Yang Fen-Fen;He Bin;Fu Xiao-Zhong;Yang Yuan-Yong;Zhou Meng;Mao Yuan-Hu;Dong Yong-Xi;Li Chun |
2 | Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2H,4H)-dione Derivatives | 期刊论文 | Yang Yuanyong;Li Yingxian;Cheng Cheng;Yang Guo;Wan Shuiying;Zhang Jiquan;Mao Yuanhu;Zhao Yonglong;Zhang Lin;Li Chun;Tang Lei |
3 | 吲哚-3-羧酸类化合物的设计、合成及体外降糖活性研究 | 期刊论文 | 张吉泉;李述敏;武婷婷;彭金刚;马晓;段习琴;汤磊 |
4 | 碱促进下空气氧化制备α-芳甲酰基硫代酰胺的便捷方法 | 期刊论文 | 王聪;姚瑶瑶;谢珺;王建塔;王飞清;张吉泉;汤磊 |
5 | 二氢齐墩果酸甲酯的合成及其药动学与生物利用度研究 | 期刊论文 | 李维;李述敏;李永;杜克斯;范菊娣;张吉泉;汤磊 |
6 | 抗肿瘤候选药物Gedatolisib在人工胃肠液和体外血浆中的稳定性研究及其降解产物分析 | 期刊论文 | 武婷婷;张宇;杜瑶;陈瑞;王丽丽;彭鸿曼;汤磊;王颖;张吉泉 |
7 | Palladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N-Acyl Arylhydrazines | 期刊论文 | Cao Jun;Chen Zi Li;Li Shu Min;Zhu Gao Feng;Yang Yuan Yong;Wang Cong;Chen Wen Zhang;Wang Jian Ta;Zhang Ji Quan;Tang Lei |
8 | Discovery of tetrahydrocarbazoles with potent hypoglycemic and hypolipemic activities | 期刊论文 | Zhang Ji Quan;Li Shu Min;Ma Xiao;Zhong Gang;Chen Rui;Li Xiao Shuang;Zhu Gao Feng;Zhou Bo;Guo Bing;Wu Hao Shu;Tang Lei |
9 | Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors | 期刊论文 | Wu Ting-Ting;Guo Qing-Qing;Chen Zi-Li;Wang Li-Li;Du Yao;Chen Rui;Mao Yuan-Hu;Yang Sheng-Gang;Huang Jing;Wang Jian-Ta;Wang Ling;Tang Lei;Zhang Ji-Quan |
10 | N-芳酰基取代的二氢吲哚-3-乙酸类衍生物的设计、合成与体外降糖活性研究 | 期刊论文 | 张吉泉;武婷婷;马才玉;马晓;王建塔;汤磊 |
11 | 降糖活性物6-苄氧基-9-(-4-氯甲苯酰基)-四氢化咔唑-3-羧酸在人工胃肠液中的稳定性研究及降解产物分析 | 期刊论文 | 张吉泉;郝阳;陈瑞;王丽丽;汤磊 |
12 | 一种取代苯并咪唑类PI3Kα/mTOR双靶点抑制剂及其药物组合物和应用 | 专利 | 张吉泉;武婷婷;王丽丽;汤磊;王领 |
13 | The synthesis of symmetrical 3,3-Disubstituted oxindoles by phosphine-catalyzed γ/γ-addition of oxindoles with allenoates | 期刊论文 | Ji-Quan Zhang;Shu-Min Li;Chun-Feng Wu;Xing-Lan Wang;Ting-Ting Wu;Yao Du;Yuan-Yong Yang;Ling-Ling Fan;Yong-Xi Dong;Jian-Ta Wang;Lei Tang |
14 | Gedatolisib的合成 | 期刊论文 | 李述敏;武婷婷;王兴兰;张吉泉;汤磊 |
15 | PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用 | 专利 | 张吉泉;李述敏;徐晓倩;武婷婷;汤磊 |
16 | Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones | 期刊论文 | Yang Yuanyong;Li Yingxian;Cheng Cheng;Yang Guo;Zhang Jiquan;Zhang Yi;Zhao Yonglong;Zhang Lin;Li Chun;Tang Lei |