新型海洋真菌天然产物Viridicatumtoxins抑制万古霉素耐药肠球菌作用机制研究
81903526
2019
H3403.微生物药物
林炜
青年科学基金项目
教授
南京中医药大学
20万元
viridicatumtoxin类化合物;万古霉素耐药肠球菌;UPP合成酶;海洋真菌;复合物晶体结构
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Structural basis of transcription activation by the global regulator Spx. | 期刊论文 | Shi Jing;Li Fangfang;Wen Aijia;Yu Libing;Wang Lu;Wang Fulin;Jin Yuanling;Jin Sha;Feng Yu;Lin Wei |
| 2 | Recent Advances on Feasible Strategies for Monoterpenoid Production in Saccharomyces cerevisiae. | 期刊论文 | Gao Qiyu;Wang Luan;Zhang Maosen;Wei Yongjun;Lin Wei |
| 3 | 藤黄提取物在制备抗菌药物中的应用 | 专利 | 林炜;陈培英;李明珠;张超;佟书娟;史婧;陈园 |
| 4 | Structural basis for transcription inhibition by E. coli SspA. | 期刊论文 | Wang Fulin;Shi Jing;He Dingwei;Tong Bei;Zhang Chao;Wen Aijia;Zhang Yu;Feng Yu;Lin Wei |
| 5 | Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis. | 期刊论文 | Liu Chanchan;Gao Qiyu;Shang Zhuo;Liu Jian;Zhou Siwei;Dang Jingjie;Liu Licheng;Lange Iris;Srividya Narayanan;Lange B Markus;Wu Qinan;Lin Wei |
| 6 | 一种怀特酮、异怀特酮的生物合成方法 | 专利 | 林炜;赵明;魏勇军;路楚洁;杜瑞;陈培英 |
| 7 | Investigations into the Antibacterial Mechanism of Action of Viridicatumtoxins | 期刊论文 | Li Weijia;Li Li;Zhang Chao;Cai Yuanheng;Gao Qiyu;Wang Fulin;Cao Yu;Lin Jinzhong;Li Jie;Shang Zhuo;Lin Wei |
| 8 | Investigations into the Antibacterial effects and potential mechanism of gambogic acid and neogambogic acid | 期刊论文 | Li Mingzhu;Chen Yuan;Wang Lijuan;Lu Chujie;Chen Peiying;Jin Yuanlin;Li Jiacong;Gao Fei;Shang Zhuo;Lin Wei |
| 9 | Structural basis for three different transcription activation strategies adopted by a single regulator SoxS | 期刊论文 | Shi Jing;Wang Lu;Wen Aijia;Wang Fulin;Zhang Yuqiong;Yu Libing;Li Fangfang;Jin Yuanling;Feng Zhenzhen;Li Jiacong;Yang yujiao;Gao Fei;Zhang Yu;Feng Yu;Wang Shuang;Zhao Wei;Lin Wei |
| 10 | Structural basis for transcription activation by Rob, a pleiotropic AraC/XylS family regulator. | 期刊论文 | Shi Jing;Wang Fulin;Li Fangfang;Wang Lu;Xiong Ying;Wen Aijia;Jin Yuanling;Jin Sha;Gao Fei;Feng Zhenzhen;Li Jiacong;Zhang Yu;Shang Zhuo;Wang Shuang;Feng Yu;Lin Wei |
| 11 | 四氢叶酸还原酶抑制剂在制备结核杆菌抗菌药物增效剂中的应用 | 专利 | 林炜;赵明;陈培英;路楚洁;李佳聪 |
| 12 | Biochemical and structural analyses reveal critical residues in δ subunit affecting its bindings to β' subunit of Staphylococcus aureus RNA polymerase. | 期刊论文 | Lin Zhaozhu;Wang Fulin;Shang Zhuo;Lin Wei |
| 13 | 香草酸甲酯及其衍生物在制备抗菌剂中的应用 | 专利 | 林炜;陈培英;金袁苓 |
| 14 | 一种美迪紫檀素的生物合成方法 | 专利 | 林炜;赵明;魏勇军;路楚洁;杜瑞;陈培英;林兆柱 |
| 15 | Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket | 期刊论文 | Lin Zhaozhu;Sun Yi;Liu Yu;Tong Shujuan;Shang Zhuo;Cai Yuanheng;Lin Wei |
| 16 | A unique binding between SspA and RNAP β(')NTH across low-GC Gram-negative bacteria facilitates SspA-mediated transcription regulation. | 期刊论文 | Wang Fulin;Feng Yu;Shang Zhuo;Lin Wei |
| 17 | 靶向UPP合成酶的抗耐药性粪肠球菌药物筛选及其抗菌机制探究 | 期刊论文 | 李维佳;佟书娟;尚卓;王佳颖;林炜 |
| 18 | 溴氧喹啉及其衍生物在制备抗菌药物中的应用 | 专利 | 林炜;陈培英;杨静;张超;佟书娟;史婧;陈园 |
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