【31200559】天然免疫系统感受因子STING与c-di-GMP复合物结构解析及TBK1激活机制研究国家自然基金项目

天然免疫系统感受因子STING与c-di-GMP复合物结构解析及TBK1激活机制研究

项目批准号： 31200559

批准年份： 2012

学科分类： C0501.结构生物学

项目负责人：欧阳松应

资助类别：青年科学基金项目

负责人职称：教授

依托单位：中国科学院生物物理研究所

资助金额： 23万元

关键词：干扰素基因刺激因子（STING）;TBK1激活;晶体结构;环鸟苷二磷酸;天然免疫

起止时间： 2013-01-01到2015-12-31

中英文摘要
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序号	标题	类型	作者
1	Mechanism of the Rpn13-induced activation of Uch37.	期刊论文	Zhu, Ping\|Dong, Yu-Hui\|Xu, Ruxiang\|Liu, Zhi-Jie\|
2	The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response	期刊论文	Liu, Zhi-Jie\|Modlin, Robert L.\|Liu, Yong-jun\|Cheng, Genhong\|
3	Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.	期刊论文	Ye, Keqiang\|Ouyang, Songying\|Cheng, Genhong\|Liu, Zhi-Jie\|
4	Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.	期刊论文	Keqiang Ye\|Songying Ouyang\|Genhong Cheng\|Zhi-Jie Liu\|
5	金黄色葡萄球菌噬菌体裂解酶LysGH15催化活性域蛋白质结晶条件筛选	会议论文
6	去泛素化酶Uch37自抑制及其激活机制研究	会议论文
7	The activation mechanism of STING-dependent interferon responses to intracellular DNA in antiviral innate immune signaling pathway	会议论文
8	Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding	期刊论文	Shaoyang Zhou\|Bing Meng\|Zhi-Jie Liu\|Songying Ouyang\|
9	Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation	期刊论文	Upur, Halmurat\|Ouyang, Songying\|Cheng, Genhong\|Liu, Zhi-jie\|
10	A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase.	期刊论文	Guo, Li\|Koonin, Eugene V\|Liu, Zhi-Jie\|Huang, Li\|
11	Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented "EF-Hand-Like" Calcium-Binding Phage Lysin	期刊论文	Yang, Yongjun\|Ouyang, Songying\|Liu, Zhi-Jie\|Han, Wenyu\|
12	Structural and functional analyses of human tryptophan 2,3-dioxygenase	期刊论文	Gu, Jianhua\|Ouyang, Songying\|Ding, Wei\|Liu, Zhi-Jie\|
13	接头蛋白STING二聚体形成和c-di-GMP结合的结构基础	会议论文
14	NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING	期刊论文	Damania, Blossom\|Shu, Hong-Bing\|Duncan, Joseph A.\|Ting, Jenny P. -Y.\|
15	Type Ⅰ Interferon Responses to Bacterial Infections	会议论文
16	New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.	期刊论文	Wang, Qiaofeng\|Ouyang, Songying\|Cheng, Genhong\|Liu, Zhi-Jie\|
17	Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential	期刊论文	Zuo, Xiaobing\|Luan, Chi-Hao\|Li, Dexin\|Liu, Zhi-Jie\|
18	发热伴血小板减少综合症中重要蛋白的抑制剂	专利	刘志杰; 欧阳松应; 焦联营; 牛峰峰; 栾棋浩; 尼尔·肖恩
19	Mechanism of the Rpn13-induced activation of Uch37	期刊论文	Zhu, Ping\|Dong, Yu-Hui\|Xu, Ruxiang\|Liu, Zhi-Jie\|
20	Structural basis for termination of AIM2-mediated signaling by p202	期刊论文	Li-Wei Hung\|Neil Shaw\|Genhong Cheng\|Zhi-Jie Liu\|
21	Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration.	期刊论文	Seeram, Ramakrishna\|Xue, Wei\|He, Liumin\|Wu, Wutian\|
22	Structural biology study of human TNF receptor associated factor 4 TRAF domain.	期刊论文	Ru, Heng\|Ding, Wei\|Ouyang, Songying\|Liu, Zhi-Jie\|
23	Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential	会议论文
24	Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding.	期刊论文	Yang Li\|Rongguang Zhang\|Genhong Cheng\|Zhi-Jie Liu\|
25	Mechanism of the Rpn13-induced activation of Uch37	期刊论文	Zhu, Ping\|Dong, Yu-Hui\|Xu, Ruxiang\|Liu, Zhi-Jie\|

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