颗粒溶素抗肿瘤作用研究

30972676
2009
C0801.固有免疫
范祖森
面上项目
研究员
中国科学院生物物理研究所
30万元
分子机制;溶酶体;抗肿瘤效应;细胞凋亡;颗粒溶素
2010-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif 期刊论文 Wang, Li|Wang, Li|Zhang, Kai|Zhang, Kai|Wu, Lianfeng|Wu, Lianfeng|Liu, Shengwu|Liu, Shengwu|Zhang, Honglian|Zhang, Honglian|Zhou, Qiangjun|Zhou, Qiangjun|Tong, Liang|Tong, Liang|Sun, Fei|Sun, Fei|Fan, Zusen|Fan, Zusen|
2 VCP cleavage by granzyme K disrupts endoplasmic reticulum associated protein degradation to force tumor target cell death. 期刊论文 Guo Y, Chen J, Shi L, Fan Z*|Guo Y, Chen J, Shi L, Fan Z*|
3 Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells 期刊论文 Hu Deqing|Hu Deqing|Liu Shengwu|Liu Shengwu|Shi Lei|Shi Lei|Li Chong|Li Chong|Wu Lianfeng|Wu Lianfeng|Fan Zusen|Fan Zusen|
4 FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. 期刊论文 Wang S.|Wang S.|Xia P.|Xia P.|Shi L.|Shi L.|Fan Z|Fan Z|
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