CPCs对单核/巨噬细胞表型转换的重编程调控及其逆转心脏纤维化重构的机制研究
U1601227
2016
H3510.药物代谢与药物动力学
余细勇
联合基金项目
教授
广州医科大学
240万元
表型转化;炎性应激;心脏祖细胞;单核细胞;心脏纤维化
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators | 期刊论文 | Wang Jianglin;Jiang Xueyan;Zhao Lixin;Zuo Shengjia;Chen Xiantong;Zhang Lingmin;Lin Zhongxiao;Zhao Xiaoya;Qin Yuyan;Zhou Xinke;Yu Xiyong |
| 2 | 脂多糖刺激下骨髓间充质干细胞分泌的外泌体对Ly6C单核巨噬细胞亚群的影响 | 期刊论文 | 霍然;傅小媚;邓赛;林潮金;王萍;秦爱萍;杨翔宇;李晓红;余细勇 |
| 3 | 一种制备心脏祖细胞的方法 | 专利 | 余细勇;李晓红;吴岳恒;杨翔宇 |
| 4 | 多能干细胞诱导剂及其应用 | 专利 | 余细勇;王义刚;梁家亮 |
| 5 | 心肺微环境的表观遗传调控与疾病防治 | 奖励 | 余细勇;胡文辉;张建业;周毅;柯华东;李仕颖;黄玉刚;吴波 |
| 6 | 青蒿琥酯对小鼠巨细胞病毒性肺炎的治疗作用 | 期刊论文 | 王萍;陈盛;黄小桃;肖小梅;湛青平;秦爱萍;余细勇 |
| 7 | Obesity Paradox and Smoking Gun: A Mystery of Statistical Confounding? | 期刊论文 | Yu Xiyong;Song Ping;Zou Minghui |
| 8 | 肿瘤微环境响应的仿生金属纳米粒用于光动力学治疗的研究 | 期刊论文 | 郑蓉蓉;赵林平;陈华清;李仕颖;余细勇 |
| 9 | 人工外泌体共递送siRNA和蛋白的递送系统的设计及体外评价 | 期刊论文 | 邓赛;张灵敏;王萍;李仕颖;林潮金;傅小媚;余细勇 |
| 10 | Effects of PON1 Gene Promoter DNA Methylation and Genetic Variations on the Clinical Outcomes of Dual Antiplatelet Therapy for Patients Undergoing Percutaneous Coronary Intervention | 期刊论文 | Lei Heping;Yu Xiyong;Wu Hong;Kang Yanhong;Zhong Wanping;Cai Liyun;Zhang Mengzhen;Chen Jiyan;Mai Liping;Ding Qingshan;Yang Min;Zhong Shilong |
| 11 | Lamin A/C在干细胞表观遗传药理学中的调控作用 | 期刊论文 | 赵林平;余细勇 |
| 12 | Knockout of beta-2 microglobulin reduces stem cell-induced immune rejection and enhances ischemic hindlimb repair via exosome/miR-24/Bim pathway in mice | 期刊论文 | Zhang Yuqing;Wang Yanli;Shao Lianbo;Pan Xiangbin;Liang Chun;Liu Bing;Zhang Yu;Xie Wenping;Yan Bing;Liu Feng;Yu Xiyong;Li Yangxin |
| 13 | 脂多糖刺激的骨髓间充质干细胞来源外泌体改善小鼠心肌梗死后炎症和纤维化 | 期刊论文 | 傅小媚;霍然;邓赛;林潮金;范景皓;王萍;李松沛;秦爱萍;邹明辉;余细勇 |
| 14 | Knockout of beta-2 microglobulin enhances cardiac repair by modulating exosome imprinting and inhibiting stem cell-induced immune rejection | 期刊论文 | Shao Lianbo;Zhang Yu;Pan Xiangbin;Liu Bin;Liang Chun;Yuqing Zhang;Wang Yanli;Yan Bing;Wenping Xie;Sun Yi;Shen Zhenya;Yu Xiyong;Li Yangxin |
| 15 | 嘧啶哌嗪酰胺类化合物及其应用 | 专利 | 胡文辉;余细勇;孙平;赵昕;吴波 |
| 16 | Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation | 期刊论文 | Jiang Xueyan;Feng Yuliang;Ye Litong;Li Xiaohong;Feng Juan;Zhang Mengzhen;Shelat Harnath S;Wassler Michael;Li Yangxin;GengYong Jian;Yu Xiyong |
| 17 | 超高效液相色谱-串联质谱法分析骨髓间充质干细胞衰老过程中的全基因组DNA甲基化水平变化 | 期刊论文 | 何国东;杨翔宇;李晓红;潘宇;余细勇 |
| 18 | Autophagy and cardiac diseases: Therapeutic potential of natural products | 期刊论文 | Wu Xiaoqian;Liu Zumei;Yu Xiyong;Xu Suowen;Luo Jiandong |
| 19 | 单核/巨噬细胞调控心梗后心肌纤维化的研究进展 | 期刊论文 | 覃宇燕;吴茜;余细勇 |
| 20 | Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer | 期刊论文 | Lei Xueping;Zhong Yihang;Huang Lijuan;Li Songpei;Fu Jijun;Zhang Lingmin;Zhang Yu;Deng Qiudi;Yu Xiyong |
| 21 | Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming | 期刊论文 | Ying Zhongfu;Xiang Ge;Zheng Lingjun;Tang Haite;Duan Lifan;Lin Xiaobing;Zhao Qiuge;Chen Keshi;Wu Yi;Xing Guangsuo;Lv Yiwang;Li Linpeng;Yang Liang;Bao Feixiang;Long Qi;Zhou Yanshuang;He Xueying;Wang Yaofeng;Gao Minghui;Pei Duanqing;Chan Wai Yee;Liu Xingguo |
| 22 | An Artifical Exosome and Its Preparation Method and Application | 专利 | 余细勇;张灵敏;邓赛;林忠晓 |
| 23 | MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1 | 期刊论文 | Liang Lu;Fu Jijun;Wang Siran;Cen Huiyu;Zhang Lingmin;Safur Rehman Mandukhail;Du Lingran;Wu Qianni;Zhang Peiquan;Yu Xiyong |
| 24 | A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy | 期刊论文 | Fan Jinghao;Fan Guiling;Yuan Ping;Deng Fuan;Liu Lingshan;Zhou Xiang;Yu Xiyong;Cheng Hong;Li Shiying |
| 25 | 2H-Chromene-3-carboxylic Acid Synthesis via Solvent-Controlled and Rhodium(III)-Catalyzed Redox-Neutral C-H Activation/[3 3] Annulation Cascade | 期刊论文 | Zhou Zhi;Bian Mengyao;Zhao Lixin;Gao Hui;Huang Junjun;Liu Xiawen;Yu Xiyong;Li Xingwei;Yi Wei |
| 26 | C-三芳基葡萄糖苷类化合物及其制备方法和应用 | 专利 | 胡文辉;余细勇;赵昕;吴波 |
| 27 | A Self-Delivery Chimeric Peptide for Photodynamic Therapy Amplified Immunotherapy | 期刊论文 | Cheng Hong;Fan Guiling;Fan Jinghao;Zheng Rongrong;Zhao Linping;Yuan Ping;Zhao Xiaoya;Yu Xiyong;Li Shiying |
| 28 | The Influence of Sex on Cardiac Physiology and Cardiovascular Diseases | 期刊论文 | Zhang Yu;Liu Bin;Zhao Ranzun;Zhang Saidan;Yu Xiyong;Li Yangxin |
| 29 | Artificial platelets for efficient siRNA delivery to clear "bad cholesterol" | 期刊论文 | Zhang YF;Qin YQ;Li H;Peng QS;Wang P;Yang LY;Chen S;Li M;Fu JJ;Yu XY;Zhang LM |
| 30 | 缺氧心肌细胞来源外泌体对Gli1~+细胞纤维化表型转换的作用机制 | 期刊论文 | 林潮金;秦爱萍;李松沛;霍然;邓赛;傅小媚;向杨;余细勇 |
| 31 | Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools | 期刊论文 | Li Songpei;Lin Zhongxiao;Jiang Xueyan;Yu Xiyong |
| 32 | Dihydrotanshinone I ameliorates cardiac hypertrophy in diabetic mice induced by chronic high-fat feeding | 期刊论文 | Li SP;Lei XP;Xiao ZK;Xia WY;Lin CJ;Fu XM;Fu JJ;Zhang LM;Yu XY |
| 33 | miR-142-3p靶向HMGB1逆转乳腺癌细胞MCF-7对阿霉素的耐药性 | 期刊论文 | 梁璐;岑慧裕;洪超;蔡晓彤;林忠晓;杜玲然;余细勇 |
| 34 | Self-Delivery Nanomedicine for O-2-Economized Photodynamic Tumor Therapy | 期刊论文 | Zhao Linping;Zheng Rongrong;Chen Huaqing;Liu Lingshan;Zhao Xiaoya;Liu Houhe;Qu Xiaozhong;Yu Xiyong;Cheng Hong;Li Shiying |
| 35 | Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration | 期刊论文 | Huang Wei;Feng Yuliang;Liang Jialiang;Yu Hao;Wang Cheng;Wang Boyu;Wang Mingyang;Jiang Lin;Meng Wei;Cai Wenfeng;Medvedovic Mario;Chen Jenny;Paul Christian;Davidson W Sean;Sadayappan Sakthivel;StambrookPeter J;Yu Xiyong;Wang Yigang |
| 36 | Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy | 期刊论文 | Cheng Hong;Fan Guiling;Fan Jinghao;Yuan Ping;Deng Fuan;Qiu Xiaozhong;Yu Xiong;Li Shiying |
| 37 | Heart failure detection device based on nucleic acid methylation changes and its application | 专利 | 余细勇;林忠晓;常继硕;张灵敏 |
| 38 | Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair | 期刊论文 | Han Chaoshan;Zhou Jin;Liang Chun;Liu Bin;Pan Xiangbin;Zhang Yu;Wang Yanli;Yan Bing;Xie Wenping;Liu Feng;Yu Xiyong;Li Yangxin |
| 39 | 干细胞来源外泌体在心肌损伤修复中的作用 | 期刊论文 | 林潮金;李松沛;邓赛;傅小媚;秦爱萍;余细勇 |
| 40 | Homotypic Targeting Delivery of siRNA with Artificial Cancer Cells | 期刊论文 | Zhang Lingmin;Deng Sai;Zhang Yanfen;Peng Qingsheng;Li Huan;Wang Ping;Fu Xiaomei;Lei Xueping;Qin Aiping;Yu Xiyong |
| 41 | 表观遗传药理学 | 专著 | 余细勇;李学军;段大跃 |
| 42 | Triple-Targeting Delivery of CRISPR/Cas9 to Reduce the Risk of Cardiovascular Diseases | 期刊论文 | Zhang Lingmin;Wang Le;Xie Yangzhouyun;Wang Peng;Deng Sai;Qin Aiping;Zhang Jiangjiang;Yu Xiyong;Zheng Wenfu;Jiang Xingyu |
| 43 | 液质联用法测定大鼠心力衰竭过程中全基因组DNA及总RNA的甲基化水平变化 | 期刊论文 | 常继硕;林忠晓;张燕芬;胡渊;余细勇 |
| 44 | 一种乏氧激活阿霉素前药及其制备方法 | 专利 | 李仕颖;江雪燕;成红;余细勇 |
| 45 | 一种细胞转染的蛋白质载体 | 专利 | 余细勇;缪迎羚 |
| 46 | Data mining in Raman imaging in a cellular biological system | 期刊论文 | Liu Yajun;Michelle Kyne;Wang Cheng;Yu Xiyong |
| 47 | 《表观遗传药理学》 | 奖励 | 余细勇 |
| 48 | Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy | 期刊论文 | Cheng Hong;Fan JingHao;Zhao Linping;Fan Guiling;Zheng Rongrong;Qiu Xiaozhong;Yu Xiyong;Li Shiying;Zhang Xianzheng |
| 49 | 调控细胞微环境靶向治疗肿瘤心脏病的研究 | 奖励 | 余细勇;李仕颖;郭伟圣;易伟;成红;张灵敏;江雪燕;周毅;林忠晓 |
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