靶向低氧反应相关的信号通路联合治疗肺动脉高压的作用及机制研究
81970052
2019
H0107.肺循环与肺血管疾病
汤海洋
面上项目
教授
广州医科大学
55万元
肺动脉高压;肺血管疾病;肺血管内皮细胞;动脉性肺动脉高压;肺血管平滑肌细胞
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension | 期刊论文 | Yinan Shi;Chenxin Gu;Tongtong Zhao;Yangfan Jia;Changlei Bao;Ang Luo;Qiang Guo;Ying Han;Jian Wang;Stephen M. Black;Ankit A. Desai;Haiyang Tang |
| 2 | Editorial: Pathophysiology and Pathogenic Mechanisms of Pulmonary Vascular Disease | 期刊论文 | Jinsheng Zhu;Jiwang Chen;Jian Wang;Ankit A. Desai;Stephen M. Black;Haiyang Tang |
| 3 | Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension | 期刊论文 | Shuxin Liang;Manivannan Yegambaram;Ting Wang;Jian Wang;Stephen M. Black;Haiyang Tang |
| 4 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy | 期刊论文 | Shuxin Liang;Changlei Bao;Zi Yang;Shiyun Liu;Yanan Sun;Weitao Cao;Ting Wang;Tae-Hwi Schwantes-An;John S. Choy;Samisubbu Naidu;Ang Luo;Wenguang Yin;Stephen M. Black;Jian Wang;Pixin Ran;Ankit A. Desai;Haiyang Tang |
| 5 | Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension | 期刊论文 | Yanan Sun;Shreya Sangam;Qiang Guo;Jian Wang;Haiyang Tang;Stephen M. Black;Ankit A. Desai |
| 6 | Quantitative Proteomic and Phosphoproteomic Profiling of Lung Tissues from Pulmonary Arterial Hypertension Rat Model | 期刊论文 | Ang Luo;Yangfan Jia;Rongrong Hao;Yafang Yu;Xia Zhou;Chenxin Gu;Meijuan Ren;Haiyang Tang |
| 7 | Hypoxia-Inducible Factor 2-Alpha Mediated Gene Sets Differentiate Pulmonary Arterial Hypertension | 期刊论文 | Jinsheng Zhu;Li Zhao;Yadan Hu;Guoqi Cui;Ang Luo;Changlei Bao;Ying Han;Tong Zhou;Wenju Lu;Jian Wang;Stephen M. Black;Haiyang Tang |
| 8 | Saluisn-β contributes to endothelial dysfunction in monocrotaline-induced pulmonary arterial hypertensive rats | 期刊论文 | Yan Pan;Aidong Chen;Xingxing Wang;Changlei Bao;Shuxin Liang;Haiyang Tang;Ying Han |
| 9 | Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models | 期刊论文 | Changlei Bao;Qian He;Hui Wang;Yanan Sun;Yahang Xu;Yan Pan;Yadan Hu;Shichuang Zheng;Shuxin Liang;Ang Luo;Tanzilan Nahar;Jiwang Chen;Haiyang Yang;Ying Han |
| 10 | The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension | 期刊论文 | Changlei Bao;Shuxin Liang;Ying Han;Zi Yang;Shiyun Liu;Yanan Sun;Shichuang Zheng;Yuzhu Li;Ting Wang;Yali Gu;Kang Wu;Stephen M. Black;Jian Wang;Steffan T. Nawrocki;Jennifer S. Carew;Jason X.-J. Yuan;Haiyang Tang |
| 11 | Rescuing lung development through embryonic inhibition of histone acetylation | 期刊论文 | Giangela Stokes;Zhuowei Li;Nicole Talaba;William Genthe;Maria B Brix;Betty Pham;Mark D Wienhold;Gracia Sandok;Rebecca Hernan;Julia Wynn;Haiyang Tang;Diana M Tabima;Allison Rodgers;Timothy A Hacker;Naomi C Chesler;Pan Zhang;Rabi Murad;Jason X-J Yuan;Yufeng Shen;Wendy K Chung;David J McCulley |
| 12 | Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells | 期刊论文 | Ang Luo;Rongrong Hao;Xia Zhou;Yangfan Jia;Haiyang Tang |
| 13 | Salusin-β, a TOR2A gene product, promotes proliferation, migration, fibrosis, and calcification of smooth muscle cells and accelerates the imbalance of vasomotor function and vascular remodeling in monocrotaline-induced pulmonary hypertensive rats | 期刊论文 | Xingxing Wang;Aidong Chen;Ruihua Hu;Feng Zhang;Shuxin Liang;Changlei Bao;Xuanxuan Liu;Haiyang Tang;Ying Han |
| 14 | SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics | 期刊论文 | Shreya Sangam;Xutong Sun;Tae-Hwi Schwantes-An;Manivannan Yegambaram;Qing Lu;Yinan Shi;Todd Cook;Amanda Fisher;Andrea L. Frump;Anna Coleman;Yanan Sun;Shuxin Liang;Howard Crawford;Katie A. Lutz;Avinash D. Maun;Michael W Pauciulo;Jason H. Karnes;Ketul R. Chaudhary;Duncan J. Stewart;Paul R Langlais;Mohit Jain;Mona Alotaibi;Tim Lahm;Yan Jin;Haiwei Gu;Haiyang Tang;William C Nichols;Stephen M Black;Ankit A. Desai |
| 15 | Pulmonary vessel casting in a rat model of monocrotaline-mediated pulmonary hypertension | 期刊论文 | Zhongkai Zhu;Yifan Wang;Amy Long;Tianyu Feng;Maria Ocampo;Sunny Chen;Haiyang Tang;Qiang Guo;Richard Minshall;Ayako Makino;Wei Huang;Jiwang Chen |
| 16 | Editorial: Mitochondrial Metabolism in Ischemic Heart Disease | 期刊论文 | Lei Yang;Shijun Wang;Jian Wu;Lei-Lei Ma;Yang Li;Haiyang Tang |
| 17 | RNA Modification Signature of Peripheral Blood as a Potential Diagnostic Marker for Pulmonary Hypertension | 期刊论文 | Liwen Zhang;Yuzhu Li;Jian Wang;Cheng Hong;Wenju Lu;Yongcun Qu;Stephen M. Black;Qi Chen;Tong Zhou;Wanzhu Jin;Enkui Duan;Haiyang Tang;Ying Zhang |
| 18 | Proteomic and Phosphoproteomic Analysis of Right Ventricular Hypertrophy in the Pulmonary Hypertension Rat Model | 期刊论文 | Ang Luo;Yangfan Jia;Rongrong Hao;Xia Zhou;Changlei Bao;Lei Yang;Chenxin Gu;Haiyang Tang;Ai-Ai Chu |
| 19 | Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension | 期刊论文 | Xuanxuan Liu;Xingxing Wang;Yan Pan;Li Zhao;Shuo Sun;Ang Luo;Changlei Bao;Haiyang Tang;Ying Han |
| 20 | Pathogenic Mechanisms of Pulmonary Arterial Hypertension Homeostasis Imbalance of Endothelium-Derived Relaxing and Contracting Factors | 期刊论文 | Jinsheng Zhu;Lei Yang;Yangfan Jia;Angela Balistrieri;Dustin R. Fraidenburg;Jian Wang;Haiyang Tang;Jason X-J Yuan |
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