机械敏感性离子通道蛋白Piezo1在肺动脉高压发生发展中的作用及机制研究
81970057
2019
H0107.肺循环与肺血管疾病
王健
面上项目
教授
广州医科大学
56万元
肺动脉高压;血流动力学应激;肺血管重塑;Piezo1
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 雌激素及其代谢物在肺动脉高压中的研究进展 | 期刊论文 | 魏锋;冯华焯;陈旭;王健 |
| 2 | 钙池操纵性钙通道在肺动脉高压发病中的作用及干预系列研究 | 奖励 | 卢文菊;王健;陈豫钦;赖宁;张弋;杨凯;张晨婷;付欣;江倩 |
| 3 | Visibility, wind speed, and dew point temperature are important factors in SARS‐CoV‐2 transmissibility | 期刊论文 | Dansha Zhou;Elizabeth W. Wang;Chi Hou;Jing Liao;Jiarui Zhang;Xin Fu;Jiyuan Chen;Yue Xing;Wei Hong;Zhe Zhang;Yuanwei Chen;Huazhuo Feng;Yilin Chen;Qifeng Yang;Huosheng Zhang;Zicong Li;Weici Feng;Ting Wang;Ziying Lin;Chenting Zhang;Kai Yang;Wenju Lu;Jian Wang;Yuqin Chen |
| 4 | Upregulation of Piezo1 Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells from Idiopathic Pulmonary Arterial Hypertension Patients | 期刊论文 | Jing Liao;Wenju Lu;Yuqin Chen;Xin Duan;Chenting Zhang;Xiaoyun Luo;Ziying Lin;Jiyuan Chen;Shiyun Liu;Han Yan;Yilin Chen;Huazhuo Feng;Dansha Zhou;Zizhou Zhang;Xu Chen;Qifeng Yang;Xinyi Liu;Haiyang Tang;Jing Li;Ayako Makino;Jason Yuan;Nanshan Zhong;Kai Yang;Jian Wang |
| 5 | Airway Delivery of Streptococcus Salivarius is Sufficient to Induce Experimental Pulmonary Hypertension in Rat | 期刊论文 | Chenting Zhang;Tingting Zhang;Yue Xing;Wenju Lu;Jiyuan Chen;Xiaoyun Luo;Xuefen Wu;Shiyun Liu;Lishi Chen;Zizhou Zhang;Dansha Zhou;Ziying Lin;Yuqin Chen;Mingmei Xiong;Jason X.‐J. Yuan;Kai Yang;Jian Wang |
| 6 | 国家科学技术进步奖-钟南山呼吸疾病防控创新团队 | 奖励 | 钟南山;何建行;冉丕鑫;沈华浩;唐芹;周玉民;杨子锋;关伟杰;梁文华;郑劲平;赖克方;黎毅敏;李靖;陈荣昌;王健 |
| 7 | Potential biomarkers and therapeutic targets of idiopathic pulmonary arterial hypertension | 期刊论文 | Wenjun He;Xi Su;Lingdan Chen;Chunli Liu;Wenju Lu;Tao Wang;Jian Wang |
| 8 | Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats | 期刊论文 | Jiang Qian;Liu Chunli;Liu Shiyun;Lu Wenju;Li Yi;Luo Xiaoyun;Ma Ran;Zhang Chenting;Chen Haixia;Chen Yuqin;Zhang Zizhou;Hong Cheng;Guo Wenliang;Wang Tao;Yang Kai;Wang Jian |
| 9 | Respiratory Microbiome Profile of Pediatric Pulmonary Hypertension Patients Associated With Congenital Heart Disease | 期刊论文 | Ting Wang;Yue Xing;Bingming Peng;Kai Yang;Chenting Zhang;Yuqin Chen;Gang Geng;Qubei Li;Jian Fu;Mi Li;Zhengxiu Luo;Zhou Fu;Jian Wang |
| 10 | 儿童肺动脉高压靶向药物应用的研究进展 | 期刊论文 | 王婷;邢越;李想;王健 |
| 11 | Impacts of anaesthesia strategies on mouth-lung microbial signature: Evidence from bronchoscopy sampling and sequencing | 期刊论文 | Chunli Tang;Chenting Zhang;Qian Jiang;Rongmei Geng;Jingnan Zhai;Jian Wang;Shiyue Li;Kai Yang |
| 12 | A novel rat model of pulmonary hypertension induced by mono treatment with SU5416 | 期刊论文 | Yuqin Chen;Meidan Kuang;Shiyun Liu;Chi Hou;Xin Duan;Kai Yang;Wenjun He;Jing Liao;Qiuyu Zheng;Guofa Zou;Haixia Chen;Han Yan;Jiyuan Chen;Yi Li;Ying Zhou;Xiaoyun Luo;Qian Jiang;Haiyang Tang;Wenju Lu;Jian Wang |
| 13 | Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model | 期刊论文 | Meidan Kuang;Yilin Chen;Yue Xing;Min Du;Huazhuo Feng;Qifeng Yang;Dongmei Wen;Xuanyi Li;Kai Yang;Ziying Lin;Ning Lai;Qian Jiang;Shiyun Liu;Dansha Zhou;Wei Hong;Xin Fu;Wenju Lu;Tengteng Zhao;Jian Wang;Yuqin Chen |
| 14 | Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats | 期刊论文 | Zhang Chenting;Lu Wenju;Luo Xiaoyun;Liu Shiyun;Li Yi;Zheng Qiuyu;Liu Wenyan;Wu Xuefen;Chen Yuqin;Jiang Qian;Zhang Zizhou;Gu Guoping;Chen Jiyuan;Chen Haixia;Liao Jing;Liu Chunli;Hong Cheng;Tang Haiyang;Sun Dejun;Yang Kai;Wang Jian |
| 15 | Sodium Tanshinone IIA Sulfonate Enhances the BMP9-BMPR2-Smad1/5/9 Signaling Pathway in Rat Pulmonary Microvascular Endothelial Cells and Human Embryonic Stem Cell-derived Endothelial Cells. | 期刊论文 | Jian Wang;Wenyan Liu;Wenju Lu;Xiaoyun Luo;Yongrui Lin;Shiyun Liu;Jing Qian;Chenting Zhang;Haixia Chen;Yi Li;Xiang Li;Jiyuan Chen;Yuqin Chen;Qian Jiang;Chunli Liu;Cheng Hong;Tao Wang;Haiyang Tang;Nanshan Zhong;Jun Yang;Kai Yang;Dejun Sun |
| 16 | Tetramethylpyrazine, a Promising Drug for Treatment of Pulmonary Hypertension | 期刊论文 | Yuqin Chen;Wenju Lu;Kai Yang;Xin Duan;Mengxi Li;Xiuqing Chen;Jie Zhang;Meidan Kuang;Shiyun Liu;Xiongting Wu;Guofa Zou;Chunli Liu;Cheng Hong;Wenjun He;Jing Liao;Chi Hou;Zhe Zhang;Qiuyu Zheng;Jiyuan Chen;Nuofu Zhang;Haiyang Tang;Rebecca R.Vanderpool;Ankit A.Desai;Franz Rischard;Stephen M.Black;Joe G.N.Garcia;Ayako Makino;Jason X.‐J.Yuan;Nanshan Zhong;Jian Wang |
| 17 | Microbiome and metabolome dysbiosis of the gut-lung axis in pulmonary hypertension | 期刊论文 | Jiyuan Chen;Dansha Zhou;Jinrui Miao;Chenting Zhang;Xiang Li;Huazhuo Feng;Yue Xing;Zizhou Zhang;Changlei Bao;Ziying Lin;Yuqin Chen;Jason X.-J. Yuan;Dejun Sun;Kai Yang;Jian Wang |
| 18 | Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist | 期刊论文 | Qiuyu Zheng;Wenju Lu;Han Yan;Xin Duan;Yuqin Chen;Chenting Zhang;Xiaoyun Luo;Jiyuan Chen;Chao Wang;Shiyun Liu;Yi Li;Haiyang Tang;Shamin Rahimi;Shayan Rahimi;Jason X-J Yuan;Nanshan Zhong;Kai Yang;Jian Wang |
| 19 | 机械敏感离子通道蛋白Piezo1在肺动脉高压中的研究进展 | 期刊论文 | 李想;陈豫钦;林子英;王健 |
| 20 | Upregulation of mechanosensitive channel Piezo1 involved in high shear stress-induced pulmonary hypertension | 期刊论文 | Jiyuan Chen;Jinrui Miao;Dansha Zhou;Jing Liao;Ziyi Wang;Ziying Lin;Chenting Zhang;Xiaoyun Luo;Yi Li;Xiang Li;Shiyun Liu;Yue Xing;Zizhou Zhang;Manjia Zhao;Sophia Parmisano;Yuqin Chen;Jason X.-J. Yuan;Kai Yang;Dejun Sun;Jian Wang |
| 21 | Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension | 期刊论文 | Chenting Zhang;Tingting Zhang;Wenju Lu;Xin Duan;Xiaoyun Luo;Shiyun Liu;Yuqin Chen;Yi Li;Jiyuan Chen;Jing Liao;Dansha Zhou;Xu Chen;Huazhuo Feng;Guoping Gu;Tao Wang;Haiyang Tang;Ayako Makino;Nanshan Zhong;Jason X.-J. Yuan;Kai Yang;Jian Wang |
| 22 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells | 期刊论文 | Kai Yang;Shiyun Liu;Han Yan;Wenju Lu;Xiaoqian Shan;Haixia Chen;Changlei Bao;Huazhuo Feng;Jing Liao;Shuxin Liang;Lei Xu;Haiyang Tang;Jason X.-J. Yuan;Nanshan Zhong;Jian Wang |
| 23 | 人工智能在肺动脉高压辅助诊断中的应用进展 | 期刊论文 | 陈纪元;周丹莎;李想;王健 |
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