利用基因编辑技术靶向清除人卵子中突变线粒体的研究
81871162
2018
H0413.卵母细胞发育、成熟、受精及其异常
范勇
面上项目
研究员
广州医科大学
57万元
诱导多能干细胞;卵子;线粒体基因病;基因编辑;胚胎干细胞
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency | 期刊论文 | Yan Long;Wu Yixuan;Li Li;Wu Jun;Zhao Feiyan;Gao Zheng;Liu Wenjing;Li Tianda;Fan Yong;Hao Jie;Liu Jianqiao;Wang Hongmei |
| 2 | Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment | 期刊论文 | Winanto;Khong Zi Jian;Soh Boon-Seng;Fan Yong;Ng Shi-Yan |
| 3 | Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain | 期刊论文 | Senlin Yin;Keying Lu;Tao Tan;Jie Tang;Jingkuan Wei;Xu Liu;Xinlei Hu;Haisu Wan;Wei Huang;Yong Fan;Dan Xie;Yang Yu |
| 4 | 一种提高修正的人三原核受精卵体外培养囊胚发育率的方法 | 专利 | 范勇;朱海瑛 |
| 5 | Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells | 期刊论文 | Pek Nicole Min Qian;Phua Qian Hua;Ho Beatrice Xuan;Pang Jeremy Kah Sheng;Hor Jin Hui;An Omer;Yang Henry He;Yu Yang;Fan Yong;Ng Shi Yan;Soh Boon Seng |
| 6 | Human germline editing: Insights to future clinical treatment of diseases | 期刊论文 | Li Y;Kang X;Pang JKS;Soh BS;Yu Y;Fan Y |
| 7 | Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development | 期刊论文 | Hai-Ying Zhu;Xiang-Jin Kang;Long Jin;Pu-Yao Zhang;Han Wu;Tao Tan;Yang Yu;Yong Fan |
| 8 | Epidermal growth factor induces a trophectoderm lineage transcriptome resembling that of human embryos during reconstruction of blastoids from extended pluripotent stem cells | 期刊论文 | Yingying Zhang;Chenrui An;Yanhong Yu;Jiajing Lin;Long Jin;Chaohui Li;Tao Tan;Yang Yu;Yong Fan |
| 9 | 基于体外诱导EPS细胞发育形成类囊胚结构的方法 | 专利 | 于洋;范勇;谭韬 |
| 10 | A lncRNA-miRNA-mRNA network for human primed, naive and extended pluripotent stem cells | 期刊论文 | Ma Zhenglai;Li Yanni;Zhang Yingying;Chen Jiaxin;Tan Tao;Fan Yong |
| 11 | Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation | 期刊论文 | Long Jin;Hai-Ying Zhu;Xiang-Jin Kang;Li-Ping Lin;Pu-Yao Zhang;Tao Tan;Yang Yu;Yong Fan |
| 12 | Generation of human blastocyst-like structures from pluripotent stem cells | 期刊论文 | Fan Yong;Min Zheying;Alsolami Samhan;Ma Zhenglai;Zhang E.;Chen Wei;Zhong Ke;Pei Wendi;Kang Xiangjin;Zhang Puyao;Wang Yongliang;Zhang Yingying;Zhan Linfeng;Zhu Haiying;An Chenrui;Li Rong;Qiao Jie;Tan Tao;Li Mo;Yu Yang |
| 13 | Loss of Raptor induces Sertoli cells into an undifferentiated state in mice | 期刊论文 | Minyu Xie;Xiao Hu;Lei Li;Zhi Xiong;Hanbin Zhang;Yuge Zhuang;Zicong Huang;Jinsheng Liu;Jingyao Lian;Chuyu Huang;Qiang Xie;Xiangjin Kang;Yong Fan;Xiaochun Bai;Zhenguo Chen |
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