基于血小板膜伪装的CRISPR-Cas9递送纳米囊的构建及其精准治疗高胆固醇血症的研究
81700382
2017
H0214.动脉粥样硬化与动脉硬化
张灵敏
青年科学基金项目
教授
广州医科大学
20万元
精准治疗;刚性纳米囊;高胆固醇血症;CRISPR-Cas9;血小板膜
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | An Artificial Exosome and Its Preparation Method and Application | 专利 | Yu Xiyong;Zhang Lingmin;Deng Sai;Lin Zhongxiao |
| 2 | CuS Nanodot-Loaded Thermosensitive Hydrogel for Anticancer Photothermal Therapy | 期刊论文 | Fu Ji-jun;Zhang Jian-ye;Li Song-pei;Zhang Ling-min;Lin Zhong-xiao;Liang Lu;Qin Ai-ping;Yu Xi-yong |
| 3 | 仿生纳米递送系统及其制备方法和应用 | 专利 | 张灵敏;余细勇;李欢;林忠晓 |
| 4 | 基于核酸甲基化变化的心衰检测装置和应用 | 专利 | 余细勇;林忠晓;常继硕;张灵敏 |
| 5 | Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer | 期刊论文 | Lei Xueping;Zhong Yihang;Huang Lijuan;Li Songpei;Fu Jijun;Zhang Lingmin;Zhang Yu;Deng Qiudi;Yu Xiyong |
| 6 | Homotypic Targeting Delivery of siRNA with Artificial Cancer Cells. | 期刊论文 | Zhang Lingmin;Deng Sai;Zhang Yanfen;Peng Qingsheng;Li Huan;Wang Ping;Fu Xiaomei;Lei Xueping;Qin Aiping;Yu Xiyong |
| 7 | 一种能够沉默Pcsk9蛋白的siRNA、其纳米递送系统及应用 | 专利 | 张灵敏;余细勇;张燕芬;林忠晓 |
| 8 | 制备心脏祖细胞的方法 | 专利 | 余细勇;王江林;张灵敏 |
| 9 | Artificial Platelets for Efficient siRNA Delivery to Clear "Bad Cholesterol". | 期刊论文 | Zhang Yanfen;Qin Yuyan;Li Huan;Peng Qingsheng;Wang Ping;Yang Langyu;Chen Sheng;Li Ming;Fu Jijun;Yu Xiyong;Zhang Lingmin |
| 10 | 人工外泌体共递送siRNA和蛋白的递送系统的设计及体外评价 | 期刊论文 | 邓赛;张灵敏;王萍;李仕颖;林潮金;傅小媚;余细勇 |
| 11 | 靶向递送siRNA仿生纳米颗粒、其制备方法及应用 | 专利 | 张灵敏;余细勇;邓赛;林忠晓 |
| 12 | 一种人工外泌体、其制备方法及应用 | 专利 | 余细勇;张灵敏;邓赛;林忠晓 |
| 13 | Preparation, characterization and in vitro-in vivo evaluation of bortezomib supermolecular aggregation nanovehicles. | 期刊论文 | Chen Ming-Yue;Xiao Ze-Kuan;Lei Xue-Ping;Li Jie-Xia;Yu Xi-Yong;Zhang Jian-Ye;Ye Guo-Dong;Guo Yu-Juan;Mo Guangquan;Li Chu-Wen;Zhang Yu;Zhang Ling-Min;Lin Zhi-Qiang;Fu Ji-Jun |
| 14 | Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators | 期刊论文 | Wang Jianglin;Jiang Xueyan;Zhao Lixin;Zuo Shengjia;Chen Xiantong;Zhang Lingmin;Lin Zhongxiao;Zhao Xiaoya;Qin Yuyan;Zhou Xinke;Yu Xi-Yong |
| 15 | 广东省高校科技成果转化路演大赛初赛入围奖 | 奖励 | 余细勇;张灵敏 |
| 16 | High-Performance Dual Combination Therapy for Cancer Treatment with Hybrid Membrane-Camouflaged Mesoporous Silica Gold Nanorods. | 期刊论文 | Li Huan;Peng Qingsheng;Yang Langyu;Lin Yinshan;Chen Sheng;Qin Yuyan;Li Songpei;Yu Xiyong;Zhang Lingmin |
| 17 | Triple-Targeting Delivery of CRISPR/Cas9 to Reduce the Risk of Cardiovascular Diseases | 期刊论文 | Zhang Lingmin;Wang Le;Xie Yangzhouyun;Wang Peng;Deng Sai;Qin Aiping;Zhang Jiangjiang;Yu Xiyong;Zheng Wenfu;Jiang Xingyu |
| 18 | HEART FAILURE DETECTION DEVICE BASED ON NUCLEIC ACID METHYLATION CHANGES AND ITS APPLICATION | 专利 | Yu Xiyong;Lin Zhongxiao;Chang Jishuo;Zhang Lingmin |
| 19 | MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1 | 期刊论文 | Liang Lu;Fu Jijun;Wang Siran;Cen Huiyu;Zhang Lingmin;Mandukhail Safur Rehman;Du Lingran;Wu Qianni;Zhang Peiquan;Yu Xiyong |
| 20 | 广东省药理学会科技成果一等奖 | 奖励 | 余细勇;李仕颖;郭伟圣;易伟;成红;张灵敏;江雪燕;周毅;林忠晓 |
| 21 | 一种CRISPR/Cas9递送系统及其制备方法和应用 | 专利 | 蒋兴宇;张灵敏;郑文富;王鹏 |
| 22 | 2018年第三届表观遗传与生物医药研究国际会议优秀论文Poster奖 | 奖励 | 张灵敏 |
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