p53信号通路调控异常在肺动脉高压发病中的机制研究
81630004
2016
H0107.肺循环与肺血管疾病
王健
重点项目
教授
广州医科大学
270万元
鼠双微体;肺动脉高压;低氧诱导因子-1;p53;肺抵抗蛋白
2017-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats | 期刊论文 | Zhang Chenting;Lu Wenju;Luo Xiaoyun;Liu Shiyun;Li Yi;Zheng Qiuyu;Liu Wenyan;Wu Xuefen;Chen Yuqin;Jiang Qian;Zhang Zizhou;Gu Guoping;Chen Jiyuan;Chen Haixia;Liao Jing;Liu Chunli;Hong Cheng;Tang Haiyang;Sun Dejun;Yang Kai;Wang Jian |
| 2 | Orai1, 2, 3 and. STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells | 期刊论文 | Wang Jian;Xu Chuyi;Zheng Qiuyu;Yang Kai;Lai Ning;Wang Tao;Tang Haiyang;Lu Wenju |
| 3 | Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. | 期刊论文 | Liao Jing;Lu Wenju;Chen Yuqin;Duan Xin;Zhang Chenting;Luo Xiaoyun;Lin Ziying;Chen Jiyuan;Liu Shiyun;Yan Han;Chen Yilin;Feng Huazhuo;Zhou Dansha;Chen Xu;Zhang Zizhou;Yang Qifeng;Liu Xinyi;Tang Haiyang;Li Jing;Makino Ayako;Yuan Jason X-J;Zhong Nanshan;Yang Kai;Wang Jian |
| 4 | 肺动脉高压动物模型研究进展 | 期刊论文 | 陈豫钦;邝美丹;廖静;卢文菊;王健 |
| 5 | 离体血管环张力系统标准化测定大鼠肺动静脉张力的方法学研究 | 期刊论文 | 吴雄婷;邝美丹;欧阳萱;李翼;袁铭敏;卢文菊;王健;陈豫钦 |
| 6 | Resolvin E1 Attenuates Pulmonary Hypertension by Suppressing Wnt7a/β-Catenin Signaling | 期刊论文 | Liu G;Wan N;Liu Q;Chen Y;Cui H;Wang Y;Ren J;Shen X;Lu W;Yu Y;Shen Y;Wang J |
| 7 | Establishment and evaluation of chronic obstructive pulmonary disease model by chronic exposure to motor vehicle exhaust combined with lipopolysaccharide instillation | 期刊论文 | Shu Jiaze;Lu Wenju;Yang Kai;Zheng Qiuyu;Li Defu;Li Yi;Kuang Meidan;Liu Hanwei;Li Ziying;Chen Yuqin;Zhang Chenting;Luo Xiaoyun;Huang Junyi;Wu Xiongting;Tang Haiyang;Wang Jian |
| 8 | Potential biomarkers and therapeutic targets of idiopathic pulmonary arterial hypertension | 期刊论文 | He W;Su X;Chen L;Liu C;Lu W;Wang T;Wang J |
| 9 | A novel rat model of pulmonary hypertension induced by mono treatment with SU5416 | 期刊论文 | Chen Yuqin;Kuang Meidan;Liu Shiyun;Hou Chi;Duan Xin;Yang Kai;He Wenjun;Liao Jing;Zheng Qiuyu;Zou Guofa;Chen Haixia;Yan Han;Chen Jiyuan;Li Yi;Zhou Ying;Luo Xiaoyun;Jiang Qian;Tang Haiyang;Lu Wenju;Wang Jian |
| 10 | The causality between CFTR and pulmonary hypertension: insights from Mendelian randomization studies | 期刊论文 | Yang Qifeng;Zhang Zizhou;Liao Jing;Zhang Jiarui;He Wenjun;Zhang Chenting;Yang Kai;Lu Wenju;Hong Cheng;Liu Xinyi;Ning Yao;Wang Rui;Wang Jian;Chen Yuqin |
| 11 | 低氧诱导因子在肺动脉高压发病中的作用及机制 | 期刊论文 | 颜涵;郑秋玉;杨凯;陈豫钦;王健 |
| 12 | Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist | 期刊论文 | Qiuyu Zheng;Wenju Lu;Han Yan;Xin Duan;Yuqin Chen;Chenting Zhang;Xiaoyun Luo;Jiyuan Chen;Chao Wang;Shiyun Liu;Yi Li;Haiyang Tang;Shamin Rahimi;Shayan Rahimi;Jason X.-J. Yuan;Nanshan Zhong;Kai Yang;Jian Wang |
| 13 | 新型肺动脉高压大鼠模型血流动力学测定方法的建立与评价[J]. ,2018,41( 6 ): 484-489. | 期刊论文 | 郑秋玉;邝美丹;李翼;吴雄婷;黄君怡;张晨婷;刘汉威;卢文菊;王健;陈豫钦 |
| 14 | Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension | 期刊论文 | Zhang Chenting;Zhang Tingting;Lu Wenju;Duan Xin;Luo Xiaoyun;Liu Shiyun;Chen Yuqin;Li Yi;Chen Jiyuan;Liao Jing;Zhou Dansha;Chen Xu;Feng Huazhuo;Gu Guoping;Wang Tao;Tang Haiyang;Makino Ayako;Zhong Nanshan;Yuan Jason X. -J;Yang Kai;Wang Jian |
| 15 | 广东省科技进步二等奖 | 奖励 | 卢文菊;王健;陈豫钦;赖宁;张弋;杨凯;张晨婷;付欣;江倩 |
| 16 | 一种细胞缺氧培养箱 | 专利 | 王健;陈纪元;孙德俊;陈豫钦;卢文菊;廖静 |
| 17 | 钟南山呼吸疾病防控创新团队 | 奖励 | 钟南山;何建行;冉丕鑫;沈华浩;唐芹;周玉民;杨子锋;关伟杰;梁文华;郑劲平;赖克方;黎毅敏;李靖;陈荣昌;王健 |
| 18 | Structural and functional definition of the pulmonary vein system in a chronic hypoxia-induced pulmonary hypertension rat model | 期刊论文 | Wu Xiongting;Lu Wenju;He Mengzhang;Chen Haixia;Chen Yuqin;Duan Xin;Zheng Qiuyu;Li Yi;Chen Jiyuan;Liu Shiyun;Liao Jing;Kuang Meidan;Lin Ziying;Yang Kai;Wang Jian |
| 19 | Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study | 期刊论文 | Chen Yuqin;He Wenjun;Ouyang Haiping;Liu Chunli;Hong Cheng;Wang Tao;Yang Kai;Lu Wenju;Wang Jian |
| 20 | Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling | 期刊论文 | He Yuhu;Zuo Caojian;Jia Daile;Bai Peiyuan;Kong Deping;Chen Di;Liu Guizhu;Li Juanjuan;Wang Yuanyang;Chen Guilin;Yan Shuai;Xiao Bing;Zhang Jian;Piao Linjuan;Li Yanli;Deng Yi;Li Bin;Roux Philippe P.;Andreasson Katrin I;Breyer Rich;Su Yunchao;Wang Jian;Lyu Ankang;Shen Yujun;Yu Ying |
| 21 | 气体麻醉下小动物气管插管支架 | 专利 | 王健;陈纪元;孙德俊;陈豫钦;汤海洋;林子英;卢文菊;廖静;张宇;苗瑾瑞;李翼 |
| 22 | Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition | 期刊论文 | Huang Junyi;Lu Wenju;Ouyang Haiping;Chen Yuqin;Zhang Chenting;Luo Xiaoyun;Li Meichan;Shu Jiaze;Zheng Qiuyu;Chen Haixia;Chen Jiyuan;Tang Haiyang;Sun Dejun;Yuan Jason X-J;Yang Kai;Wang Jian |
| 23 | 水通道蛋白与肺部疾病的关系 | 期刊论文 | 欧阳海萍;陈豫钦;卢文菊;王健 |
| 24 | 一种可用贴壁细胞假药实验的细胞培养装置 | 专利 | 陈豫钦;王健;卢文菊 |
| 25 | 新生大鼠右心室心肌细胞的原代培养及鉴定 | 期刊论文 | 邝美丹;陈海霞;廖静;何汶俊;陈奕霖;江倩;卢文菊;王健;陈豫钦 |
| 26 | Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats | 期刊论文 | Jiang Qian;Liu Chunli;Liu Shiyun;Lu Wenju;Li Yi;Luo Xiaoyun;Ma Ran;Zhang Chenting;Chen Haixia;Chen Yuqin;Zhang Zizhou;Hong Cheng;Guo Wenliang;Wang Tao;Yang Kai;Wang Jian |
| 27 | Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension | 期刊论文 | Wang Ziyi;Yang Kai;Zheng Qiuyu;Zhang Chenting;Tang Haiyang;Babicheva Aleksandra;Jiang Qian;Li Meichan;Chen Yuqin;Carr Shane G.;Wu Kang;Zhang Qian;Balistrieri Angela;Wang Christina;Song Shanshan;Ayon Ramon J.;Desai Ankit A.;Black Stephen M.;Garcia Joe G. N.;Makino Ayako;Yuan Jason X-J;Lu Wenju;Wang Jian |
| 28 | 新型冠状病毒对肺气血屏障结构和功能的影响及机制研究进展 | 期刊论文 | 邢越;王健;陈豫钦 |
| 29 | Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension | 期刊论文 | Chen Yuqin;Lu Wenju;Yang Kai;Duan Xin;Li Mengxi;Chen Xiuqing;Zhang Jie;Kuang Meidan;Liu Shiyun;Wu Xiongting;Zou Guofa;Liu Chunli;Hong Cheng;He Wenjun;Liao Jing;Hou Chi;Zhang Zhe;Zheng Qiuyu;Chen Jiyuan;Zhang Nuofu;Tang Haiyang;Vanderpool Rebecca R.;Desai Ankit A.;Rischard Franz;Black Stephen M.;Garcia Joe G. N.;Makino Ayako;Yuan Jason X. -J.;Zhong Nanshan;Wang Jian |
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