利用“3i”体系建立人类原始态胚胎干细胞系及其microRNA表达谱的研究

81370766
2013
H0414.早期胚胎发育
范勇
面上项目
研究员
广州医科大学
70万元
人类;原始态多能性;胚胎干细胞;胚胎发育
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种提高基因打靶的效率的方法及β-球蛋白基因位点的碱基原位修复方法 专利 范勇;杨翌;李小平
2 One-Step Biallelic and Scarless Correction of a β-Thalassemia Mutation in Patient-Specific iPSCs without Drug Selection 期刊论文 Yali Liu;Yi Yang;Xiangjin Kang;Bin Lin;Qian Yu;Bing Song;Ge Gao;Yaoyong Chen;Xiaofang Sun;Xiaoping Li;Lei Bu;Yong Fan
3 Chromosome microduplication in somatic cells decreases the genetic stability of human reprogrammed somatic cells and results in pluripotent stem cells. 期刊论文 Yu Y;Chang L;Zhao H;Li R;Fan Y;Qiao J
4 Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology 期刊论文 Guoqiang Li;Yang Yu;Yong Fan;Congru Li;Xiaocui Xu;Jialei Duan;Rong Li;Xiangjin Kang;Xin Ma;Xuepeng Chen;Yuwen Ke;Jie Yan;Ying Lian;Ping Liu;Hongcui Zhao;Yaoyong Chen;Xiaofang Sun;Jianqiao Liu;Jie Qiao;Jiang Liu
5 Improved Efficiency of Microsurgical EnucleatedTripronuclear Zygotes Development and EmbryonicStem Cell Derivation by Supplementing EpidermalGrowth Factor, Brain-Derived Neurotrophic Factor,and Insulin-Like Growth Factor-1 期刊论文 Fan Y;Li R;Huang J;Zhao HC;Ding T;Sun X;Yu Y;Qiao J
6 干细胞资源库的建立及其在β-地中海贫血治疗中的应用 奖励 孙筱放;高绍荣;范勇;王译萱;刘维强;骆玉梅;杨媛媛;陈欣洁
7 Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and in-vitro-matured oocytes 期刊论文 Fan Y;Zhao HC;Liu J;Tan T;Ding T;Li R;Zhao Y;Yan J;Sun X;Yu Y;Qiao J
8 Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region 期刊论文 Yu Yang;Gao Qian;Zhao Hong-cui;Li Rong;Gao Jiang-man;Ding Ting;Bao Si-yu;Zhao Yue;Sun Xiao-fang;Fan Yong;Qiao Jie
9 Defining Differentially Methylated Regions Specific for the Acquisition of Pluripotency and Maintenance in Human Pluripotent Stem Cells via Microarray 期刊论文 He WenYin;Kang XiangJin;Du HongZi;Song Bing;Lu ZhenYu;Huang Yuling;Wang Ding;Sun Xiaofang;Yu Yang;Fan Yong
10 Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells 期刊论文 Xiangjin Kang Qian Yu Yuling Huang;Bing Song Yaoyong Chen Xingcheng Gao;Wenyin He;Xiaofang Sun;Yong Fan
11 Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs 期刊论文 Yi Yang;Han Wu;Xiangjin Kang;Yanhui Liang;Ting Lan;Tianjie Li;Tao Tan;Jiangyun Peng;Quanjun Zhang;Geng An;Yali Liu;Qian Yu;Zhenglai M;Ying Lian;Boon Seng Soh;Qingfeng Chen;Ping Liu;Yaoyong Chen;Xiaofang Sun;Rong Li;Xiumei Zhen;Ping Liu;Yang Yu;Xiaoping Li;Yong Fan
12 Introducing precise genetic modifications into human 3PN embryos byCRISPR/Cas-mediated genome editing 期刊论文 Kang X He W Huang Y Yu Q Chen Y Gao X Sun X;Fan Yong
13 Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse. 期刊论文 Xiang Jin Kang;Chiong Isabella Noelle Caparas;Boon Seng Soh;Yong Fan
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