Exosome介导干细胞组蛋白甲基化调控心肌重构的研究
81330007
2013
H0202.心肌损伤、修复、重构和再生
余细勇
重点项目
教授
广州医科大学
290万元
心肌重构;组蛋白甲基化;心脏祖细胞;组蛋白修饰;外泌体
2014-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Fn14诱导人皮肤成纤维细胞分泌细胞外基质 | 期刊论文 | 麦丽萍;陈少贤;肖定璋;陈景;杨敏;余细勇;刘培庆 |
| 2 | Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation | 期刊论文 | Jiang Xue-Yan;Feng Yu-Liang;Ye Li-Tong;Li Xiao-Hong;Feng Juan;Zhang Meng-Zhen;Shelat Harnath S.;Wassler Michael;Li Yangxin;Geng Yong-Jian;Yu Xi-Yong |
| 3 | 外泌体在心血管疾病中的研究进展 | 期刊论文 | 肖静;余细勇 |
| 4 | Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy | 期刊论文 | Hong Cheng;Rong-Rong Zheng;Gui-Ling Fana;Jing-Hao Fan;Lin-Ping Zhao;Xue-Yan Jiang;Bin Yang;Xi-Yong Yu;Shi-Ying Li;Xian-Zheng Zhang |
| 5 | Heat Shock Improves Sca-1(+) Stem Cell Survival and Directs Ischemic Cardiomyocytes Toward a Prosurvival Phenotype Via Exosomal Transfer: A Critical Role for HSF1/miR-34a/HSP70 Pathway | 期刊论文 | Feng Yuliang;Huang Wei;Meng Wei;Jegga Anil G.;Wang Yigang;Cai Wenfeng;Kim Ha Won;Pasha Zeeshan;Wen Zhili;Rao Fang;Modi Rohan M.;Yu Xiyong;Ashraf Muhammad |
| 6 | The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research | 期刊论文 | Li Yangxin;Song Yao-Hua;Liu Bin;Yu Xi-Yong |
| 7 | Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration | 期刊论文 | Huang Wei;Feng Yuliang;Liang Jialiang;Yu Hao;Wang Cheng;Wang Boyu;Wang Mingyang;Jiang Lin;Meng Wei;Cai Wenfeng;Medvedovic Mario;Chen Jenny;Paul Christian;Davidson W. Sean;Sadayappan Sakthivel;Stambrook Peter J.;Yu Xi-Yong;Wang Yigang |
| 8 | Generation of Functional Human Cardiac Progenitor Cells by High-Efficiency Protein Transduction | 期刊论文 | Li Xiao-Hong;Li Qianqian;Jiang Lin;Deng Chunyu;Liu Zaiyi;Fu Yongheng;Zhang Mengzhen;Tan Honghong;Feng Yuliang;Shan Zhixin;Wang Jianjun;Yu Xi-Yong |
| 9 | Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3 beta Signaling Pathway | 期刊论文 | Shen Congcong;Zhou Jin;Wang Xiaoxiao;Yu Xi-Yong;Liang Chun;Liu Bin;Pan Xiangbin;Zhao Qiong;Song Jenny Lee;Wang Jiajun;Bao Meiyu;Wu Chaofan;Li Yangxin;Song Yao-Hua |
| 10 | 心脏干细胞分泌的exosome对氧化应激下心肌细胞的保护作用研究 | 期刊论文 | 肖静;潘宇;李晓红;姜霖;杨翔宇;吴岳恒;雷和平;余细勇 |
| 11 | A biomimetic cascade nanoreactor for tumor targeted starvation therapy amplified chemotherapy. Biomaterials | 期刊论文 | Cheng Hong;Jiang Xue-Yan;Zheng Rong-Rong;Zuo Sheng-Jia;Zhao Lin-Ping;Fan Gui-Ling;Xie Bo-Ru;Yu Xi-Yong;Li Shi-Ying;Zhang Xian-Zheng |
| 12 | Upregulation of 5-hydroxytryptamine receptor signaling in coronary arteries after organ culture. | 期刊论文 | Deng CY;Yang H;Kuang SJ;Rao F;Xue YM;Zhou ZL;Liu XY;Shan ZX;Li XH;Lin QX;Wu SL;Yu XY. |
| 13 | 人血管紧张素Ⅱ2型受体基因慢病毒表达载体的构建 | 期刊论文 | 雷和平;麦丽萍;朱杰宁;单志新;杨敏;林秋雄;余细勇 |
| 14 | Left ventricular deformation associated with cardiomyocyte Ca2+ transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats | 期刊论文 | Liu XY;Liu FC;Deng CY;Zhang MZ;Yang M;Xiao DZ;Lin QX;Cai ST;Kuang SJ;Chen J;Chen SX;Zhu JN;Yang H;Rao F;Fu YH;Yu XY |
| 15 | 干细胞再生和修复心肌的现状与挑战 | 期刊论文 | 冯宇亮;余细勇 |
| 16 | Effects of PON1 Gene Promoter DNA Methylation and Genetic Variations on the Clinical Outcomes of Dual Antiplatelet Therapy for Patients Undergoing Percutaneous Coronary Intervention | 期刊论文 | Lei He-Ping;Yu Xi-Yong;Wu Hong;Kang Yan-Hong;Zhong Wan-Ping;Cai Li-Yun;Zhang Meng-Zhen;Chen Ji-Yan;Mai Li-Ping;Ding Qing-Shan;Yang Min;Zhong Shi-Long |
| 17 | TLR2/NLRC5参与棕榈酸诱导的心肌细胞凋亡及相关机制研究 | 期刊论文 | 刘晓颖;蔡诗婷;杨敏;萧定璋;谭红红;陈景;陈少贤;陈红梅;杨慧;余细勇 |
| 18 | 聚乙烯亚胺-蛋白纳米复合体转染蛋白进入骨髓间充质干细胞的应用研究 | 期刊论文 | 姜霖;吴岳恒;李晓红;潘宇;肖静;杨翔宇;冯媛;余细勇 |
| 19 | MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair | 期刊论文 | Shao Lianbo;Zhang Yu;Lan Beibei;Wang Juanjuan;Zhang Zhiwei;Zhang Lulu;Xiao Pengli;Meng Qingyou;Geng Yong-jian;Yu Xi-yong;Li Yangxin |
| 20 | Fn14 Promotes Differentiation of Human Mesenchymal Stem Cells into Heart Valvular Interstitial Cells by Phenotypic Characterization | 期刊论文 | Huang W;Xiao DZ;Wang YG;Shan ZX;Liu XY;Lin QX;Yang M;Zhuang J;Li Y;Yu XY |
| 21 | Hedgehog通路对心肌梗死及心肌细胞缺血缺氧的作用机制研究 | 期刊论文 | 陈瑶;余细勇 |
| 22 | Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells | 期刊论文 | Liang Jialiang;Huang Wei;Cai Wenfeng;Wang Lei;Guo Linlin;Paul Christian;Yu Xi-Yong;Wang Yigang |
| 23 | 超高效液相色谱-串联质谱法分析骨髓间充质干细胞衰老过程中的全基因组DNA甲基化水平变化 | 期刊论文 | 何国东;杨翔宇;李晓红;潘宇;余细勇 |
| 24 | Transport of microRNAs via exosomes | 期刊论文 | Li Y;Shen ZY;Yu XY |
| 25 | An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization | 期刊论文 | Li Shiying;Jiang Xueyan;Zheng Rongrong;Zuo Shengjia;Zhao Linping;Fan Guiling;Fan Jinghao;Liao Yonghua;Yu Xiyong;Cheng Hong |
| 26 | Letter by Li et al Regarding Article, "MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis" | 期刊论文 | Li Yangxin;Song Yao-Hua;Yu Xi-Yong |
| 27 | 脂多糖刺激下骨髓间充质干细胞分泌的外泌体对Ly6C单核巨噬细胞亚群的影响 | 期刊论文 | 霍然;傅小媚;邓赛;林潮金;王萍;秦爱萍;杨翔宇;李晓红;余细勇 |
| 28 | 长链非编码RNA对心脏发育的表观遗传学调控研究进展 | 期刊论文 | 杨翔宇;余细勇 |
| 29 | 孕期吸烟对SD大鼠胚胎心脏发育的影响 | 期刊论文 | 叶力通;江雪燕;张梦珍;潘宇;林秋雄;单志新;姜霖;陈瑶;余细勇 |
| 30 | Diastolic Cardiac Deformation Monitoring in T2DM: A Necessary Consideration | 期刊论文 | Xiao Ying Liu;Xi Yong Yu |
| 31 | 离体大鼠冠状动脉的分离培养及张力测定技术 | 期刊论文 | 邝素娟;邓春玉;杨慧;饶芳;刘晓颖;张梦珍;朱杰宁;单志新;林秋雄;杨敏;余细勇 |
| 32 | Rapid determination of fenoldopam in human plasma by UPLC-MS/MS for pharmacokinetic analysis in patients | 期刊论文 | Wang XP;Zheng ZJ;He GD;Mai LP;Zhou ZL;Zhong SL;Lin QX;Shan ZX;Deng CY;Yang M;Yu XY |
| 33 | Obesity Paradox and Smoking Gun: A Mystery of Statistical Confounding? | 期刊论文 | Yu Xi-Yong;Song Ping;Zou Ming-Hui |
| 34 | Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools | 期刊论文 | Li Song-pei;Lin Zhong-xiao;Jiang Xue-yan;Yu Xi-yong |
| 35 | 基于N-脑利钠肽前体的美托洛尔治疗心衰的临床研究 | 期刊论文 | 王曦培;麦丽萍;何国东;饶芳;蔡秀玲;曾琼新;林秋雄;杨敏;余细勇 |
| 36 | 聚合酶链反应芯片筛选5-氟尿嘧啶对乳鼠心肌细胞心脏毒性差异表达基因的作用 | 期刊论文 | 雷和平;麦丽萍;杨慧;钟诗龙;杨敏;林秋雄;单志新;余细勇 |
| 37 | Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4 | 期刊论文 | Xiao J.;Pan Y.;Li X. H.;Yang X. Y.;Feng Y. L.;Tan H. H.;Jiang L.;Feng J.;Yu X. Y. |
| 38 | 干扰素γ刺激hUC-MSCs分泌外泌体促进调节性T细胞生成 | 期刊论文 | 杨翔宇;李晓红;肖静;胡洁媚;冯娟;霍然;何国东;吴岳恒;余细勇 |
| 39 | 2H-Chromene-3-carboxylic Acid Synthesis via Solvent-Controlled and Rhodium(III)-Catalyzed Redox-Neutral C-H Activation/[3+3] Annulation Cascade | 期刊论文 | Zhou Zhi;Bian Mengyao;Zhao Lixin;Gao Hui;Huang Junjun;Liu Xiawen;Yu Xiyong;Li Xingwei;Yi Wei |
| 40 | LaminA/C在干细胞表观遗传药理学中的调控作用 | 期刊论文 | 赵林平;余细勇 |
| 41 | Letter by Li et al Regarding Article, "MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis" | 期刊论文 | Li Yangxin;Song Yao-Hua;Yu Xi-Yong |
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