DC-SIGN介导的免疫调控在真菌性角膜炎发病机制中的研究

81870632
2018
H1301.角膜及眼表疾病
赵桂秋
面上项目
主任医师
青岛大学
57万元
基因多态性;雷帕霉素;真菌性角膜炎;DC-SIGN;DNA甲基化
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 固有免疫在真菌性角膜炎发病机制及临床治疗中的研究 奖励 赵桂秋;李翠;林静;王谦;张丽娜;杜兆东;彭旭东
2 FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway 期刊论文 Guoqiang Zhu;Guiqiu Zhao;Jing Lin;Cui Li;Qian Wang;Qiang Xu;Xudong Peng;Heng-Rui Zheng
3 Production of egg yolk antibody against A.fumigatus and its therapeutic potential for treating A.fumigatus keratitis 期刊论文 Xiaoming Huang;Xing Liu;Xudong Peng;Cui Li;Jianxin Sui;Hong Lin;Jing Lin;Guiqiu Zhao
4 Honokiol Reduces Fungal Load, Toll-Like Receptor-2, and Inflammatory Cytokines in Aspergillus fumigatus Keratitis. 期刊论文 Lu Zhan;Xudong Peng;Jing Lin;Yingxue Zhang;Han Gao;Yunan Zhu;Yu Huan;Guiqiu Zhao
5 Mincle介导的固有免疫在真菌性角膜炎中的作用及机制研究 奖励 林静;王谦;张杰;彭旭东;徐强
6 The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis 期刊论文 Junjie Luan;Xudong Peng;Jing Lin;Yingxue Zhang;Xue Tian;Lu Zhan;Guiqiu Zhao
7 Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis 期刊论文 Nan Jiang;Li Zhang;Guiqiu Zhao;Jing Lin;Qian Wang;Qiang Xu;Cui Li;Liting Hu;Xudong Peng;Feifei Yu;Ming Xu
8 Drug-loaded mesoporous carbon with sustained drug release capacity and enhanced antifungal activity to treat fungal keratitis 期刊论文 Lingwen Gu;Cui Li;Jing Lin;Qian Wang;Min Yin;Lina Zhang;Na Li;Hao Lin;Zhihu You;Siyu Wang;Daohao Li;Guiqiu Zhao
9 Regulation of LOX-1 on adhesion molecules and neutrophil infiltration in mouse Aspergillus fumigatus keratitis 期刊论文 Guoqiang Zhu;Guiqiu Zhao;Cui Li;Jing Lin;Nan Jiang;Qian Wang;Qiang Xu;Xudong Peng
10 负载那他霉素及银的纳米介孔碳滴眼液及其制备方法和应用 专利 李翠;赵桂秋;顾凌雯;李道浩;姜楠;徐强
11 Changes in corneal innervation and pain responses in fungal keratitis 期刊论文 Chang-Jie Ren;Yi-Fan Zhou;Yuan Wu;Xudong Peng;Cui Li;Qian Wang;Guoqiang Zhu;Jia You;Jie Zhang;Guiqiu Zhao;Jing Lin
12 Disparate expression of autophagy in corneas of C57BL/6 mice and BALB/c mice after Aspergillus fumigatus infection 期刊论文 Chen-Yu Li;Cui Li;Hui Li;Guiqiu Zhao;Jing Lin;Qian Wang;Xudong Peng;Qiang Xu;Guoqiang Zhu;Jia-Qian Jiang
13 Quercetin amelioratesAspergillus fumigatuskeratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines 期刊论文 Jiao Yin;Xudong Peng;Jing Lin;Yingxue Zhang;Jie Zhang;Han Gao;Xue Tian;Ranran Zhang;Guiqiu Zhao
14 Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis 期刊论文 Min Yin;Cui Li;Xudong Peng;Guiqiu Zhao;Yuan Wu;Heng-Rui Zheng;Qian Wang;Qiang Xu;Nan Jiang
15 Laccase-mediated functionalization of natamycin by gallic acids for the therapeutic effect on Aspergillus fumigatus keratitis 期刊论文 Xiaoyue Ji;Xudong Peng;Xiaojing Long;Yingxue Zhang;Jing Lin;Jiao Yin;Ranran Zhang;Guiqiu Zhao
16 Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines 期刊论文 Xue Tian;Xudong Peng;Jing Lin;Yingxue Zhang;Lu Zhan;Jiao Yin;Ranran Zhang;Guiqiu Zhao
17 Role of the IL-33/ST2/p38 signaling pathway in the immune response of corneal epithelial cells to Aspergillus fumigatus infection 期刊论文 Jia You;Jing Lin;Yi-Fan Zhou;Xudong Peng;Hong He;Cui Li;Guoqiang Zhu;Xue-Qi Zhao;Guiqiu Zhao
18 Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis 期刊论文 Jia-Qian Jiang;Cui Li;Cong-Xian Cui;Yu-Na Ma;Guiqiu Zhao;Xudong Peng;Qiang Xu;Qian Wang;Guoqiang Zhu;Chen-Yu Li
19 The role of Glabridin in antifungal and anti-inflammation effects in Aspergillus fumigatus keratitis 期刊论文 Han Gao;Xudong Peng;Lu Zhan;Jing Lin;Yingxue Zhang;Yu Huan;Guiqiu Zhao
20 Expression of macrophage migration inhibitory factor in Aspergillus fumigatus keratitis 期刊论文 Qiang Xu;Li-Ting Hu;Qian Wang;Jing Lin;Nan Jiang;Cui Li;Guiqiu Zhao
21 一种特异性Dectin-1纳米抗体及其制备方法和应用 专利 林静;赵桂秋;彭旭东;李翠;刘星;王谦
22 Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1 期刊论文 Qiaoqiao Sun;Cui Li;Jing Lin;Xudong Peng;Qian Wang;Nan Jiang;Qiang Xu;Guiqiu Zhao
23 The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection 期刊论文 Yi-Fan Zhou;Jing Lin;Xudong Peng;Cui Li;Jie Zhang;Qian Wang;Guoqiang Zhu;Jia You;Guiqiu Zhao
24 LOX-1受体在真菌性角膜炎发病机制及治疗作用的研究 奖励 赵桂秋;李翠;姜楠;胡丽婷;张丽娜;杜兆东
25 Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response 期刊论文 Yunan Zhu;Xudong Peng;Yingxue Zhang;Jing Lin;Guiqiu Zhao
26 Lipoxin A4 activates ALX/FPR2 to attenuate inflammation in Aspergillus fumigatus keratitis 期刊论文 Xiaojia Zhu;Xudong Peng;Jing Lin;Yingxue Zhang;Hong He;Guiqiu Zhao
27 Eugenol protects against Aspergillus fumigatus keratitis by inhibiting inflammatory response and reducing fungal load 期刊论文 Bing Yu;Cui Li;Lingwen Gu;Lina Zhang;Qian Wang;Yan Zhang;Jing Lin;Liting Hu;Yiyi Jia;Min Yin;Guiqiu Zhao
28 Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway. 期刊论文 Lingwen Gu;Jing Lin;Qian Wang;Cui Li;Xudong Peng;Yiqun Fan;Chunli Lu;Hao Lin;Yawen Niu;Guoqiang Zhu;Guiqiu Zhao
29 Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammation through the Promotion of Autophagy 期刊论文 Lingwen Gu;Cui Li;Xudong Peng;Hao Lin;Yawen Niu;Hengrui Zheng;Guiqiu Zhao;Jing Lin
30 一种氧化硫酸软骨素改性的那他霉素滴眼液及其制备方法 专利 赵桂秋;彭旭东;林静;李翠;田雪
31 一种用于真菌性角膜炎诊断的检测试剂定位加样装置 专利 顾凌雯;赵桂秋;林静;李翠
32 一种枝接那他霉素的氧化海藻酸纤维膜及其制备方法 专利 赵桂秋;李翠;李道浩;彭旭东;林静;尹敏;胡丽婷;刘桂波
33 Oxidized chondroitin sulfate eye drops ameliorate the prognosis of fungal keratitis with anti-inflammatory and antifungal effects. 期刊论文 Xue Tian;Xudong Peng;Xiaojing Long;Jing Lin;Yingxue Zhang;Lu Zhan;Guiqiu Zhao
34 LOX-1受体在真菌性角膜炎发病机制及临床治疗中作用的研究 奖励 赵桂秋;林静;王谦;李翠;徐强;张杰;杜兆东
35 Mammalian Ste20-like Kinase 4 Inhibits the Inflammatory Response in Aspergillus fumigatus Keratitis 期刊论文 Xing Liu;Jia You;Xudong Peng;Qian Wan;Cui Li;Nan Jiang;Chengye Che;Yifan Zhou;Hengrui Zheng;Ziyue Zhang;Guiqiu Zhao;Jing Lin
36 The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis 期刊论文 Ranran Zhang;Xudong Peng;Jing Lin;Yingxue Zhang;Lu Zhan;Xue Tian;Jiao Yin;Guiqiu Zhao
37 New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes 期刊论文 Lingwen Gu;Guofeng Ma;Cui Li;Jing Lin;Guiqiu Zhao
38 Kaempferol ameliorate the prognosis of Aspergillus fumigatus keratitis by reducing fungal load and inhibiting the Dectin-1 and p38 MAPK pathway 期刊论文 Yiyi Jia;Cui Li;Min Yin;Jing Lin;Lina Zhang;Na Li;Nan Jiang;Qiang Xu;Qian Wang;Lingwen Gu;Bing Yu;Guiqiu Zhao
39 一种酶催化制备聚槲皮素的方法及聚槲皮素的应用 专利 赵桂秋;彭旭东;林静;李翠;尹娇
40 Dectin-1介导的固有免疫在真菌性角膜炎发病机制及临床应用中的研究 奖励 赵桂秋;林静;李翠;车成业;彭旭东;王谦;胡丽婷;姜楠;张丽丽
41 Mechanism of antifungal activity and therapeutic action of β-ionone on Aspergillus fumigatus keratitis via suppressing LOX1 and JNK/p38 MAPK activation 期刊论文 Min Yin;Cui Li;Leyuan Zhang;Lina Zhang;Jing Lin;Nan Jiang;Qain Wang;Qiang Xu;Hengrui Zheng;Lingwen Gu;Yiyi Jia;Bing Yu;Guiqiu Zhao
42 Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis 期刊论文 Xing Liu;Jianxin Sui;Cui Li;Xudong Peng;Qian Wang;Nan Jiang;Qiang Xu;Luokai Wang;Jing Lin;Guiqiu Zhao
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