中药注射剂(茵栀黄)的反应性代谢谱及致敏潜因研究

81274178
2012
H3216.中药代谢与药物动力学
郭宾
面上项目
教授
湖南师范大学
70万元
小分子致敏原;茵栀黄注射剂;反应性代谢物;复方中药;活化代谢谱
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 产物探针鸡尾酒液质联用检测茵栀黄成分对P450 酶的抑制作用 会议论文 谭桢|郭宾|陈波|马铭|
2 Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement 期刊论文 Tan, Zhen|Ye, Meiling|Ding, Li|Chen, Bo|
3 Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF kappa B Signaling Plays an Important Role 期刊论文 Zou, Zuquan|Ma, Ming|Guo, Bin|Chen, Bo|
4 2015年度国际期刊杰出审稿人奖 奖励 Bin Guo||
5 基于胆汁酸代谢调控/STAT3 通路的茵栀黄抗胆汁淤积型肝损伤的分子机制 会议论文 谭桢|刘爱明|郭宾|
6 Liquid Chromatography-Mass Spectrometric Multiple Reaction Monitoring-based Strategies for Expanding Targeted Profiling towards Quantitative Metabolomics 期刊论文 Chen, Bo|Liu, Aiming|Zhu, Weitao|Yao, Shouzhuo|
7 Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations 期刊论文 Jing Zhou|Bin Guo|Yangyuan Liu|Bo Chen|
8 研究生国家奖学金 奖励 程雨晴|
9 Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation 期刊论文 Dai M|Gonzalez FJ|Liu A|Guo B|
10 Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling 期刊论文 Fang Z|Jiang C|Yang J|Gonzalez FJ|
11 The Expanding Role of Electrospray Ionization Mass Spectrometry for Probing Reactive Intermediates in Solution 期刊论文 Wang, Hua|Tang, Ling|Guo, Bin|Chen, Bo|
12 药物代谢细胞色素酶催化活性检测新技术进展(特邀封面论文) 期刊论文 刘妍妍|程雨晴|谭桢|郭宾|
13 Salt-triggered liquid phase separation and facile nanoprecipitation of aqueous colloidal gold dispersion in miscible biofluids for direct chromatographic measurement 期刊论文 M. Ma|B. Chen|S. Zhan|S. Yao|
14 基于液相色谱-质谱多反应监测的UGTs 酶活检测新方法 会议论文 程雨晴|郭宾|陈波|马铭|
15 功能食品安全检测的技术现状与对策 期刊论文 郭宾|陈应庄|马铭|陈波|
16 茵栀黄注射液抗胆汁淤积药效成分的筛选及其作用机制研究 期刊论文 谭桢|刘爱明|罗敏|郭宾|
17 研究生国家奖学金 奖励 汤领|
18 微纳尺度样品制备新型功能材料的构筑及其应用 会议论文 郭宾|蔡青云|姚守拙|
19 Single-shot multi-reaction monitoring of intact marker conjugates for quantitative profiling of human major microsomal glucuronidations and its utility to screen inhibitors from medicinal herbs 期刊论文 Wang, Meiling|Liu, Yanyan|Guo, Bin|Chen, Bo|
20 基于盐促相变分离纳米金的生物样品直接色谱测定技术 奖励 马铭|陈波|詹松|姚守拙|
21 湖南大奇科技有限公司 奖励 郭宾|曹虹剑|
22 Wide-Scope Screening of Illegal Adulterants in Dietary and Herbal Supplements via Rapid Polarity-Switching and Multistage Accurate Mass Confirmation Using an LC-IT/TOF Hybrid Instrument 期刊论文 Zhiqiang Huang|Lingling Shen|Qingsheng Zhang|Bo Chen|
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