E3泛素连接酶Skp2通过促海马PPARα降解参与抑郁症发生的机制研究

81771467
2017
H1007.心境障碍
黄超
面上项目
教授
南通大学
54万元
脑源性生长因子;海马;抑郁症;小胶质细胞;过氧化物酶体增殖物激活受体α
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Regulation of HSF1 protein stabilization: An updated review 期刊论文 Chao Huang;Jingjing Wu;Xu Lu;Jili Wang;Zhuo Chen;Rongrong Yang
2 Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome 期刊论文 Minhui Gao;Peili Hu;Zixuan Cai;Yue Wu;Dan Wang;Wenfeng Hu;Xing Xu;Yaru Zhang;Xu Lu;Dongjian Chen;Zhuo Chen;Kai Ma;Jie Wen;Hui Wang;Chao Huang
3 Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice 期刊论文 Fu Li;Chao Huang;Xu Lu;Haitao Xiang;Dan Wang;Zhuo Chen;Jinliang Chen;Haiyan He;Xiaomei Yuan
4 Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation 期刊论文 Yu Gong;Lijuan Tong;Rongrong Yang;Wenfeng Hu;Xingguo Xu;Wenjing Wang;Peng Wang;Xu Lu;Minhui Gao;Yue Wu;Xing Xu;Yaru Zhang;Zhuo Chen;Chao Huang
5 Identification of a pro-elongation effect of diallyl disulfide, a major organosulfur compound in garlic oil, on microglial process 期刊论文 Xing Xu;Peili Hu;Yaoying Ma;Lijuan Tong;Dan Wang;Yue Wu;Zhuo Chen;Chao Huang
6 Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress 期刊论文 Xu Lu;Rongrong Yang;Jinlin Zhang;Peng Wang;Yu Gong;Wenfeng Hu;Yue Wu;Minhui Gao;Chao Huang
7 SMIP004: A compound with antidepressant-like activities in mouse models 期刊论文 Dan Wang;Xing Xu;Yue Wu;Yong Ling;Minhui Gao;Peili Hu;Dongjian Chen;Xu Lu;Zhuo Chen;Hui Wang;Chao Huang
8 A review for the pharmacological effect of lycopene in central nervous system disorders 期刊论文 Dongjian Chen;Chao Huang;Zhuo Chen
9 Identification of the expression of farnesoid X receptor in astrocytes 期刊论文 Haiyan He;Zhuo Chen;Dongjian Chen;Xu Lu;Chao Huang;Jinliang Chen
10 靶向小胶质细胞的抑郁症发病机制及治疗策略研究 奖励 黄超;陆需;童丽娟
11 An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders 期刊论文 Haiyan He;Chao Huang;Zhuo Chen;Huaxing Huang;Xiaohua Wang;Jinliang Chen
12 A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities 期刊论文 Haiyan He;Yaoying Ma;Huaxing Huang;Chao Huang;Zhuo Chen;Dongjian Chen;Yiming Gu;Xiaohua Wang;Jinliang Chen
13 Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice 期刊论文 Wenfeng Hu;Jingjing Wu;Ting Ye;Zhuo Chen;Jinhua Tao;Lijuan Tong;Kai Ma;Jie Wen;Hui Wang;Chao Huang
14 A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice 期刊论文 Jianlin Ji;Haitao Xiang;Xu Lu;Pingping Tan;Rongrong Yang;Ting Ye;Zhuo Chen;Dongjian Chen;Haiyan He;Jinliang Chen;Yaoying Ma;Chao Huang
15 Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice 期刊论文 Peili Hu;Dan Wang;Yaru Zhang;Zixuan Cai;Ting Ye;Lijuan Tong;Xing Xu;Jiashu Lu;Fengguo Liu;Xu Lu;Chao Huang
16 Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review 期刊论文 Jinlin Zhang;Jingjing Wu;Fengguo Liu;Lijuan Tong;Zhuo Chen;Jinliang Chen;Haiyan He;Rong Xu;Yaoying Ma;Chao Huang
17 Evaluation of the antidepressive property of β-hydroxybutyrate in mice 期刊论文 Shengying Pan;Peili Hu;Qingsheng You;Jinliang Chen;Jingjing Wu;Yaru Zhang;Zixuan Cai;Ting Ye;Xing Xu;Zhuo Chen;Lijuan Tong;Chao Huang;Haiyan He
18 Intranasal lipopolysaccharide administration prevents chronic stress-induced depression- and anxiety-like behaviors in mice 期刊论文 Qun Lu;Haitao Xiang;Haojie Zhu;Yifan Chen;Xu Lu;Chao Huang
19 The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation 期刊论文 Chao Huang;Peng Wang;Xing Xu;Yaru Zhang;Yu Gong;Wenfeng Hu;Minhui Gao;Yue Wu;Yong Ling;Xi Zhao;Yibin Qin;Rongrong Yang;Wei Zhang
20 Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain 期刊论文 Fu Li;Haitao Xiang;Jiashu Lu;Zhuo Chen;Chao Huang;Xiaomei Yuan
21 Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress 期刊论文 Jian Qiu;Renjie Liu;Yaoying Ma;Yan Li;Zhuo Chen;Haiyan He;Jinliang Chen;Lijuan Tong;Chao Huang;Qingsheng You
22 Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition 期刊论文 Peng Wang;Yaru Zhang;Yu Gong;Rongrong Yang;Zhuo Chen;Wenfeng Hu;Yue Wu;Minhui Gao;Xing Xu;Yibin Qin;Chao Huang
23 Effects of sulforaphane in the central nervous system 期刊论文 Chao Huang;Jingjing Wu;Dongjian Chen;Jie Jin;Yue Wu;Zhuo Chen
24 Sulforaphane triggers a functional elongation of microglial process via the Akt signal 期刊论文 Yue Wu;Minhui Gao;Jingjing Wu;Peili Hu;Xing Xu;Yaru Zhang;Dan Wang;Zhuo Chen;Chao Huang
25 A review for the neuroprotective effects of andrographolide in the central nervous system 期刊论文 Jiashu Lu;Yaoying Ma;Jingjing Wu;Huaxing Huang;Xiaohua Wang;Zhuo Chen;Jinliang Chen;Haiyan he;Chao Huang
26 Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice 期刊论文 Yue Gu;Ting Ye;Pingping Tan;Lijuan Tong;Jianlin Ji;Yiming Gu;Zhongxia Shen;Xinhua Shen;Xu Lu;Chao Huang
27 Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress 期刊论文 Xiaoyou Wei;Yaoying Ma;Fu Li;Haiyan He;Huaxing Huang;Chao Huang;Zhuo Chen;Dongjian Chen;Jinliang Chen;Xiaomei Yuan
28 Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress 期刊论文 Ting Ye;Dan Wang;Zixuan Cai;Lijuan Tong;Zhuo Chen;Jiashu Lu;Xu Lu;Chao Huang;Xiaomei Yuan
29 Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress 期刊论文 Zixuan Cai;Ting Ye;Xing Xu;Minhui Gao;Yaru Zhang;Dan Wang;Yiming Gu;Haojie Zhu;Lijuan Tong;Jiashu Lu;Zhuo Chen;Chao Huang
30 Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress 期刊论文 Li Chen;Chao Huang;Zhuo Chen
31 Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice 期刊论文 Fu Li;Haitao Xiang;Yue Gu;Ting Ye;Xu Lu;Chao Huang
32 靶向小胶质细胞的抑郁症发病机制及防治策略研究 奖励 黄超;陆需;童丽娟
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