DAla2GIP-Glu-PAL对阿尔茨海默病APP/PS1转基因鼠的神经保护效应研究

31471080
2014
C0906.认知神经生物学
祁金顺
面上项目
教授
山西医科大学
81万元
APP/PS1转基因鼠;阿尔茨海默病;学习记忆;DAla2GIP-Glu-PAL;突触可塑性
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种可视微创颅内给药装置 专利 张升校;祁金顺;张军;马小雯;李玉峰;张雨薇;郭静蕙;姜涛;郭云飞;蔡红艳;原丽;王昭君;武美娜;仝嘉庆;郝明;杨菊;石辉;韩宇飞
2 抗糖尿病新药(D-Ser2)Oxm拮抗淀粉样β蛋白细胞毒性的神经保护效应观察 期刊论文 韩宇飞;H?LSCHERChristian;王昭君;张军;原丽;仝嘉庆;王丹丹;武美娜;祁金顺
3 High-intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticityof rats via activation of inflammatory response. 期刊论文 Sun LN;Li XL;Wang F;Zhang J;Wang DD;Yuan L;Wu MN;Wang ZJ;Qi JS
4 GLP-1 analogue CJC-1131 prevents amyloid protein-induced impirments of spatial memory and synaptic plasticity in rats 期刊论文 Sheng-Xiao Zhang;Hong-Yan Cai;Xiao-Wen Ma;Li Yuan;Jun Zhang;Zhao-Jun Wang;Jin-Shun Q
5 内侧隔核注射淀粉样 β 蛋白损害大鼠的长时程增强和认知行为 期刊论文 WU Mei-Na;KONG Lin-Lin;ZHANG Jun;HU Meng-Ming;WANG Zhao-Jun;CAI Hong-Yan;QI Jin-Shun
6 Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice 期刊论文 Zhang Wei;Wang Zhaojun;Wu Meina;Yang Wei;Zhang Jun;Qi Jinshun;Guo Junhong;Niu Xiaoyuan;Wang Jie;Qi JS
7 非损伤微测技术实时检测海马脑片跨膜钙离子流 期刊论文 李甜;原丽;张军;焦娟娟;祁金顺
8 Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid beta protein in male rats 期刊论文 Yue Xing-Hua;Tong Jia-Qing;Wang Zhao-Jun;Zhang Jun;Liu Xu;Liu Xiao-Jie;Cai Hong-Yan;Qi Jin-Shun
9 A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes 期刊论文 Mengming Hu;Jun Zhang;Junting Yang;Yue Cao;Jinshun Qi
10 雷帕霉素对淀粉样β蛋白所致大鼠工作记忆和突触可塑性损伤的作用观察 期刊论文 郝明;仝嘉庆;张军;武美娜;祁金顺
11 A Novel Antibody Targeting Sequence 31–35 in Amyloid b Protein Attenuates Alzheimer’s Disease-Related Neuronal Damage 期刊论文 Li Cheng;Jun Zhang;Xin-Yi Li;Li Yuan;Yan-Fang Pan;Xiao-Rong Chen;Tian-Ming Gao;Jian-Tian Qiao;Jin-Shun Qi
12 抗糖尿病药物GLP-1在阿尔茨海默病中的神经保护作用及其分子机制研究进展 期刊论文 李玉峰;张升校;祁金顺
13 [Gly14]-Humanin Protects Against Amyloid beta Peptide-Induced Impairment of Spatial Learning and Memory in Rats 期刊论文 Yuan Li;Liu Xiao-Jie;Han Wei-Na;Li Qing-Shan;Wang Zhao-Jun;Wu Mei-Na;Yang Wei;Qi Jin-Shun
14 Desipramine improves depression-like behavior and working memory by up-regulating p-CREB in Alzheimer's disease associated mice 期刊论文 Wang Dan-Dan;Li Jia;Yu Li-Peng;Wu Mei-Na;Sun Li-Na;Qi Jin-Shun
15 Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats 期刊论文 Jia-qing Tong;Jun Zhang;Ming Hao;Ju Yang;Yu-fei Han;Xiao-jie Liu;Hui Shi;Mei-na Wu;Qing-song Liu;Jin-shun Q
16 一种脑片取样及清洗装置 专利 杨俊婷;祁金顺
17 一种动物肢体角度调节器 专利 杨威;祁金顺
18 阿尔茨海默病淀粉样β蛋白神经毒机制及其时间保护作用研究 奖励 祁金顺;武美娜;张俊芳;程丽;潘艳芳;韩维娜
19 GLP-1/GIP/Gcg三受体激动剂改善阿尔茨海默病三转基因小鼠的认知行为 期刊论文 焦娟娟;H?LSCHER Christian;李甜;董雪帆;曲雪松;曹越;武美娜;王昭君;祁金顺
20 一种离体电生理实验用固定组织切片的锚 专利 张升校;张军;祁金顺;马小雯;李玉峰;张雨薇;仝嘉庆;郝明;蔡红艳;王昭君;原丽;武美娜;杨威;石辉;杨菊;韩宇飞;岳兴华
21 A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer’s disease 期刊论文 Tian Li;Juan-Juan Jiao;Christian Holscher;Mei-Na Wu;Jun Zhang;Jia-Qing Tong;Xue-Fan Dong;Xue-Song Qu;Jin-Shun Qi
22 Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats 期刊论文 Zhang Jun;Yuan Li;Kong Lin-Lin;Zhang Sheng-Xiao;Wang Zhao-Jun;Wu Mei-Na;Qi Jin-Shun;Wei Shu-Yu;Qi JS
23 Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats 期刊论文 Hong-Yan Cai;Zhao-Jun Wang;Christian Hölscher;Li Yuan;Jun Zhang;Peng Sun;Jing Li;Wei Yang;Mei-Na Wu;Jin-Shun Qi
24 一种适用于大小鼠行为学的全自动化投鼠装置 专利 张升校;蔡红艳;祁金顺;李海春;马小雯;李玉峰;张雨薇;任松洁;张军;王昭君;原丽;孙丽娜;武美娜;杨威;岳兴华;张洋;乔枫;仝嘉庆;郝明;杨菊;韩宇飞;石辉
25 Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease 期刊论文 Hong-Yan Cai;Jun-Ting Yang;Zhao-Jun Wang;Jun Zhang;Wei Yang;Mei-Na Wu;Jin-Shun Qi
26 Wnt-5a prevents A beta-induced deficits in long-term potentiation and spatial memory in rats 期刊论文 Zhang Gui-Li;Zhang Jun;Li Shao-Feng;Lei Liu;Xie Hong-Yan;Deng Fang;Feng Jia-Chun;Qi Jin-Shun
27 Colivelin Ameliorates Amyloid b Peptide-Induced Impairments in Spatial Memory, Synaptic Plasticity, and Calcium Homeostasis in Rats 期刊论文 Mei-Na Wu;Li-Wei Zhou;Zhao-Jun Wang;Wei-Na Han;Jun Zhang;Xiao-Jie Liu;Jia-Qing Tong;Jin-Shun Qi
28 Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice 期刊论文 Meina Wu;Hui Shi;Yexin He;Li Yuan;Xuesong Qu;Jun Zhang;Zhaojun Wang;Hongyan Cai;Jinshun Qi
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